Results 21 to 30 of about 22,500 (289)

Drug Repurposing of the Alcohol Abuse Medication Disulfiram as an Anti-Parasitic Agent

Frontiers in Cellular and Infection Microbiology, 2021
Parasitic infections contribute significantly to worldwide morbidity and mortality. Antibiotic treatment is essential for managing patients infected with these parasites since control is otherwise challenging and there are no vaccines available for ...
Debbie-Ann Shirley, Ishrya Sharma, Cirle A. Warren, Shannon Moonah   +3 more
doaj   +1 more source

Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites

Molecules, 2017
Based on crystallographic data of the complexes 2-alkyl(amino)ethyl-1,1-bisphosphonates–Trypanosoma cruzi farnesyl diphosphate synthase, some linear 1,1-bisphosphonic acids and other closely related derivatives were designed, synthesized and biologically
Tamila Galaka, Mariana Ferrer Casal, Melissa Storey, Catherine Li, María N. Chao, Sergio H. Szajnman, Roberto Docampo, Silvia N. J. Moreno, Juan B. Rodriguez   +8 more
doaj   +1 more source

Coumarin-Annulated Ferrocenyl 1,3-Oxazine Derivatives Possessing In Vitro Antimalarial and Antitrypanosomal Potency

Molecules, 2021
A tailored series of coumarin-based ferrocenyl 1,3-oxazine hybrid compounds was synthesized and investigated for potential antiparasitic activity, drawing inspiration from the established biological efficacy of the constituent chemical motifs.
Mziyanda Mbaba, Laura M. K. Dingle, Ayanda I. Zulu, Dustin Laming, Tarryn Swart, Jo-Anne de la Mare, Heinrich C. Hoppe, Adrienne L. Edkins, Setshaba D. Khanye   +8 more
doaj   +1 more source

Annona muricata Leaf as an Anti-Cryptosporidial Agent: An In Silico Molecular Docking Analysis and In Vivo Studies

Pharmaceuticals, 2023
Cryptosporidiosis is a serious parasitic diarrheal disease linked to the occurrence of colorectal cancer in immunocompromised patients. The FDA-approved drug nitazoxanide (NTZ) achieved a temporary effect, and relapses occur.
Eman S. El-Wakil, Hagar F. Abdelmaksoud, Majed H. Wakid, Muslimah N. Alsulami, Olfat Hammam, Haleema H. Albohiri, Marwa M. I. Ghallab   +6 more
doaj   +1 more source

Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]

, 2020
A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Amado, Patrícia, Cabral, Lília, Cojean, Sandrine, Cristiano, Maria De Lurdes, Loiseau, Philippe M., Pomel, Sébastien   +5 more
core   +1 more source

Overview of Genus Prosopis Toxicity Reports and its Beneficial Biomedical Properties [PDF]

, 2016
Secondary plant metabolites are regarded as promising sources of plant-protecting substances and they are one of the most important lines of plant defense against pests. The range of cellular targets for these substances is very wide and covers metabolic
Gamarra Luques, Carlos Diego, Hapon, María Belén, Persia, Andres, Rinaldini, Estefanía   +3 more
core   +1 more source

Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action. [PDF]

, 2006
Immunophilin is the collective name given to the cyclophilin and FK506-binding protein (FKBP) families. As the name suggests, these include the major binding proteins of certain immunosuppressive drugs: cyclophilins for the cyclic peptide cyclosporin A ...
Adams, Aliberti, Alphey, Angus Bell, Antony P. Page, Argaet, Banerjee, Banumathy, Belfiore, Bell, Bell, Bell, Berriman, Blumenthal, Blumenthal, Borel, Bozdech, Braun, Bua, Carlton, Chakraborty, Chakraborty, Chappell, Chappell, Cianciotto, Cohen, Colgan, Dao-Thi, Denkers, Dobson, Dolinski, Dornan, Dornan, Dutta, Fischer, Florens, Galat, Galat, Gavigan, Gavigan, Gilleard, Golding, Hacker, Hall, High, Hirtzlin, Hong, Hope, Kamath, Kay, Ke, Khattab, Kiang, Klinkert, Klinkert, Knobloch, Kumar, Kumar, Kumar, Le Roch, Lightowlers, Lorberg, Ma, Ma, Ma, Matsuda, McLauchlan, Mikol, Monaghan, Monaghan, Moro, Osman, Ostoa-Saloma, Oz, Page, Page, Page, Page, Page, Page, Page, Paul Monaghan, Pelle, Pereira, Peterson, Picken, Pratt, Rascher, Reddy, Riggs, Rossi, Shirane, Silverman, Taylor, Tuo, Valle, Wang, Weiwad, Williams, Yarovinsky, Yu, Zorio   +101 more
core   +1 more source

Peroxide impact on the fate of veterinary drugs in fertilizers [PDF]

, 2020
The presence of veterinary medicines in organic manure causes soil contamination which contributes to increasing resistance of indigenous microflora to drugs and results in greater susceptibility of people to allergies.
Kalka, Joanna, Marciocha, Dorota, Surmacz-Górska, Joanna, Turek-Szytow, Jolanta   +3 more
core   +1 more source

Ivermectin - old drug, new tricks? [PDF]

, 2017
Ivermectin is one of the most important drugs in veterinary and human medicine for the control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or Medicine, some 35 years after its remarkable discovery.
Devaney, Eileen, Gillan, Victoria, Laing, Roz   +2 more
core   +1 more source

The Modern Approach To The Complex Therapy Of Demodicosis [PDF]

, 2016
Demodicosis is one of the most common diseases of the skin. Despite the large number of scientific publications on this issue the question of the etiology and pathogenesis of this disease still remains unresolved and the development of more effective ...
Revenko, Z. (Zhanetta)
core   +3 more sources