Results 51 to 60 of about 23,125 (311)

The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10 [PDF]

Open Biology, 2019
Minichromosome maintenance protein 10 (Mcm10) is essential for DNA unwinding by the replisome during S phase. It is emerging as a promising anti-cancer target as MCM10 expression correlates with tumour progression and poor clinical outcomes. Here we used
Carolyn N. Paulson, Kristen John, Ryan M. Baxley, Fredy Kurniawan, Kayo Orellana, Rawle Francis, Alexandra Sobeck, Brandt F. Eichman, Walter J. Chazin, Hideki Aihara, Gunda I. Georg, Jon E. Hawkinson, Anja-Katrin Bielinsky   +12 more
doaj   +1 more source

Zinc(II)-Sterol Hydrazone Complex as a Potent Anti-Leishmania Agent: Synthesis, Characterization, and Insight into Its Mechanism of Antiparasitic Action

Pharmaceutics, 2023
Searching for new alternatives for treating leishmaniasis, we present the synthesis, characterization, and biological evaluation against Leishmania amazonensis of the new ZnCl2(H3)2 complex.
Gonzalo Visbal, Rodrigo M. S. Justo, Gabrielle dos Santos da Silva e Miranda, Sara Teixeira de Macedo Silva, Wanderley de Souza, Juliany Cola Fernandes Rodrigues, Maribel Navarro   +6 more
doaj   +1 more source

Phytotherapy in zoo animals [PDF]

, 2015
Phytotherapy is one of the oldest medical disciplines and was traditionally based on empiricism (Reichling et al., 2008). Nowadays, its use as an additional integral component of evidence based medicine is well accepted in human medicine (Finkelmann ...
Hoby, S., Walkenhorst, M., Wenker, C.
core   +1 more source

In Vitro Antitrypanosomal and Antibacterial Activity of Aqueous, Hydroethanolic and Ethanolic Extracts of Rumex obtusifolius L. Leaf and Root. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Plant extracts are an important raw material for the development of new drugs. Rumex obtusifolius L., popularly known as ‘bitter dock’, has significant pharmacological properties. This study evaluated the in vitro antitrypanosomal activity of aqueous, hydroethanolic and ethanolic extracts from the leaf and roots of R. obtusifolius L.
Borges GK, Das Neves GB, Reichardt L, Costa UMD, Miletti LC, Bastos-Pereira AL.   +5 more
europepmc   +2 more sources

The Antiparasitic Compound Licochalcone A Is a Potent Echinocytogenic Agent That Modifies the Erythrocyte Membrane in the Concentration Range Where Antiplasmodial Activity Is Observed

Antimicrobial Agents and Chemotherapy, 2004
Hanne L. Ziegler, Harald S. Hansen, Dan Stærk, S. Brøgger Christensen, Henry Hägerstrand, Jerzy W. Jaroszewski   +5 more
openalex   +4 more sources

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs [PDF]

, 2017
Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs.
Alsford, Sam, Horn, David, Konno, Aya, Kumar, Ambika, Meredith, Emma Louise, Seifert, Karin, Szular, Joanna, Wilkinson, Shane R.   +7 more
core   +4 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Review of Chagas Disease and Treatment Obstacles to Eradication [PDF]

, 2019
The World Health Organization and the Center for Disease Control reports Chagas disease, or American trypanosomiasis, as a major neglected tropical disease prevalent in 21 endemic Latin American countries.
Sherman, Emily
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information

Case Reports in Oncology, 2021
Fenbendazole is a benzimidazole anthelmintic agent, with a broad antiparasitic range in animals such as dogs and pigs. The agent is also reported to exert antitumor effects and inhibit microtubule-associated tubulin polymerization, but its safety and ...
Teppei Yamaguchi, Junichi Shimizu, Yuko Oya, Yoshitsugu Horio, Toyoaki Hida   +4 more
doaj   +1 more source