Results 71 to 80 of about 23,125 (311)

Identification of 3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors against Trypanothione Reductase from Leishmania Infantum Using Molecular Docking and ADMET Prediction

Molecules, 2021
Polyphenolic and Terpenoids are potent natural antiparasitic compounds. This study aimed to identify new drug against Leishmania parasites, leishmaniasis’s causal agent. A new in silico analysis was accomplished using molecular docking, with the Autodock
Sarra Maamri, Khedidja Benarous, Mohamed Yousfi   +2 more
doaj   +1 more source

Efficacy of Essential Oils of Thymus vulgaris and Origanum vulgare on Echinococcus granulosus [PDF]

, 2014
The aim of the present work was to determine the in vitro effect of T. vulgaris and O. vulgare essential oils against E. granulosus protoscoleces and cysts. Essential oils were added to the medium resulting in thymol final concentrations of 10 μg/mL. The
Denegri, Guillermo Maria, Eguaras, Martin Javier, Elissondo, María Celina, Gende, Liesel Brenda, Maggiore, Marina Alejandra, Pensel, Patricia Eugenia   +5 more
core   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

In vivo evaluation of antiparasitic effects of Artemisia abrotanum and Salvia officinalis extracts on Syphacia obvelata, Aspiculoris tetrapetra and Hymenolepis nana parasites [PDF]

, 2014
Objective: To evaluate the effects of Salvia officinalis and Artemisia abrotanum extracts against digestive system parasites of mice. Methods: The ethanol extract was prepared and dissolved in distilled water. The mebendazole was used as positive control
Amirmohammadi, Mahdi., Bahmani, Mahmoud., Eftekhari, Zohre., Khajoenia, Shole., Qorbani, Mostafa., Rafieian-Kopaei, Mahmoud.   +5 more
core   +2 more sources

Bacterial Pigments as Potential Antitumor Agents Against Gastrointestinal Cancers: A Comprehensive Systematic Review

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Gastrointestinal cancers (GICs) constitute one of the leading causes of cancer‐related morbidity and mortality worldwide. Despite currently available therapeutic strategies, new approaches and procedures are needed for their prevention and treatment.
Raúl Vergara, Ricardo F. S. Pereira, Carla C. C. R. de Carvalho, Jose Prados, Consolación Melguizo, Raul Ortiz   +5 more
wiley   +1 more source

Bioinformatics-guided decoding of the Ancylostoma duodenale genome for the identification of potential vaccine targets

BMC Genomics
Ancylostoma duodenale, a parasitic nematode worm, is found to be involved in various infections, including intestinal blood loss, protein malnutrition, and anemia.
Mohibullah Shah, Hira Anum, Asifa Sarfraz, Md. Aktaruzzaman, Al Riyad Hasan, Muhammad Umer Khan, Khaled Fahmi Fawy, Sarah A. Altwaim, Saeed M. N. Alasmari, Abid Ali, Umar Nishan, Ke Chen   +11 more
doaj   +1 more source

Advancing Trypanosoma cruzi N-myristoyltransferase as a drug target for Chagas disease through in silico discovery and biochemical evaluation

Frontiers in Molecular Biosciences
IntroductionN-myristoylation is a crucial lipid modification that governs protein localization, intracellular trafficking, and function in eukaryotic cells.
Diana González García, Angel Torres, Alan Talevi, Lucas N. Alberca, Miguel A. Beltran, Frida Lara, Marina Da Silva Ferreira, Marina Da Silva Ferreira, Priscila S. G. Farani, Priscila S. G. Farani, Igor C. Almeida, Rosa A. Maldonado   +11 more
doaj   +1 more source

ANTHELMINTIC DRUGS EFFICACY AGAINST BOVINE FASCIOLIASIS

Ветеринарная патология, 2022
Parasitic diseases in cattle are widespread in the territory of the Russian Federation. At the farms of Udmurtia various kinds of ruminants parasitic fauna are represented and therefore the vast use of antiparasitic drugs entails a range of problems ...
E. S. Klimova
doaj   +1 more source

Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs. [PDF]

, 2012
Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I nitroreductases, enzymes found ...
Alsford, Alsford, Armstrong, Begleiter, Belinda S. Hall, Bern, Bienen, Bot, Brun, Bryant, Chaudhuri, Chen, Clarkson, Danson, Danson, Emma Louise Meredith, Ernster, Faeder, Fang, Fang, Fang, Fang, Garavaglia, Gascon, Goodwin, Guerra, Hall, Hall, Hall, Henderson, Hirumi, Hoet, Hu, Iyanagi, Jaiswal, Jarrom, Koder, Kubata, Müller, Nillius, Nivinskas, Nixon, O'Brien, Pal, Parkinson, Peterson, Pinto, Powis, Purkayastha, Race, Race, Ramos, Rassi, Shane R. Wilkinson, Stein, Stuart, Surve, Tatsumi, Tedeschi, Torri, Torri, Urech, Ward, Watanabe, Whiteway, Wilkinson, Yan, Zenno, Zenno   +68 more
core   +1 more source

Sustainable Microwave‐Enhanced Synthesis of 2‐Substituted Benzofurans From o‐Alkynylanisoles in Acidic Deep Eutectic Solvents

European Journal of Organic Chemistry, EarlyView.
A microwave‐enhanced sustainable and versatile approach to substituted benzofurans from 2‐alkynylanisoles enabled by an active Brønsted acidic deep eutectic solvent. The research on alternative media for organic transformations remains a highly demanding topic.
Alessandra Gritti, Angelica Sita, Mehri Goudarzi, Stefano Fedeli, Elison Lepore, Donatella Nava, Matteo Tiecco, Alessandro Caselli, Valentina Pirovano, Giorgio Abbiati   +9 more
wiley   +1 more source