Fexinidazole interferes with the growth and structural organization of Trypanosoma cruzi
Scientific Reports, 2022 Fexinidazole (FEX) is a heterocyclic compound and constitutes the first 100% oral treatment drug for African trypanosomiasis. Its effectiveness against Trypanosoma brucei encouraged the investigation of its antiparasitic potential against T.
Aline Araujo Zuma, Wanderley de Souza
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Evaluating 5-nitrofurans as trypanocidal agents [PDF]
, 2013 The nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targeting Trypanosoma brucei, the causative agent of human African trypanosomiasis.
Alvarez, G +6 more
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Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management
Journal of Applied Toxicology, EarlyView.ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz +3 more
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Drug Induced Liver Injury by Prophylactic Administration of Albendazole
The Korean Journal of Gastroenterology, 2019 Albendazole is used as a typical antiparasitic agent worldwide. The side effects of albendazole may include nausea, vomiting, abdominal pain, dizziness, headache, alopecia, and increased liver enzymes. Mild elevation of the liver enzyme has been reported
Sang Yi Moon +2 more
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Microbial metabolites in nutrition, healthcare and agriculture [PDF]
, 2017 Microorganisms are a promising source of an enormous number of natural products, which have made significant contribution to almost each sphere of human, plant and veterinary life. Natural compounds obtained from microorganisms have proved their value in
Anshumali Mittal +3 more
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Journal of Applied Toxicology, EarlyView.ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos +4 more
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Liquid and vapour phase of lavandin (Lavandula × intermedia) essential oil: chemical composition and antimicrobial activity [PDF]
, 2019 Essential oils from Lavandula genus and the obtained hybrids are widely used for different purposes such as perfume production in the cosmetic field and for its biological properties.
Garzoli, S. +5 more
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Unraveling the Physicochemical Landscape of Organoselenium Compounds in Nanocarrier Systems
The Chemical Record, EarlyView.Main nanocarriers employed to enhance the bioavailability and transport of organoselenium compounds. The image illustrates the key interaction forces that stabilize these organoselenium species in solution, enabling their application in drug delivery systems, catalysis, photoelectronic devices, and sensing technologies. In recent years, publications on
Romelly Eugenia Rojas Ramírez +3 more
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Opportunities and Challenges in Developing a Cryptosporidium Controlled Human Infection Model for Testing Antiparasitic Agents [PDF]
, 2021 Rajiv S. Jumani +13 more
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Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers [PDF]
, 2016 Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria.
Bandara Herath, H. M. T. +16 more
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