Results 71 to 80 of about 142,623 (303)

Inappropriate Use of Proton Pump Inhibitors Increases Cardiovascular Events in Patients with Coronary Heart Disease

International Journal of General Medicine, 2022
Wen Hu,1,* Yunhao Luo,2,* Xiujuan Yang1 1Department of Cardiology, Chengdu Seventh People’s Hospital, Chengdu, People’s Republic of China; 2Department of Critical Care Medicine, Chengdu First People’s Hospital, Chengdu, People’s Republic of China&
Hu W, Luo Y, Yang X
doaj  

Effects of clopidogrel and prednisone on platelet function in healthy dogs

Journal of Veterinary Internal Medicine, 2020
Background Glucocorticoids cause hypercoagulability, but it is unknown if they counteract clopidogrel's antiplatelet effects. Hypothesis/Objectives Determine the effects of clopidogrel and prednisone on platelet function. Animals Twenty‐four healthy dogs.
John Thomason, Allison P. Mooney, Joshua M. Price, Jacqueline C. Whittemore   +3 more
doaj   +1 more source

Personalized Approaches to Antiplatelet Treatment for Cardiovascular Diseases: An Umbrella Review

, 2023
Angelo Oliva,1,2 Davide Cao,1,3 Alessandro Spirito,1 Johny Nicolas,1 Brunna Pileggi,1,4 Karim Kamaleldin,1 Birgit Vogel,1 Roxana Mehran1 1The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City, NY,
Kamaleldin K, Nicolas J, Spirito A, Cao D, Vogel B, Pileggi B, Mehran R, Oliva A   +7 more
core  

Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset [PDF]

, 2010
<p><b>Background and Purpose:</b> Antiplatelets (APs) may increase the risk of symptomatic intracerebral hemorrhage (ICH) following intravenous thrombolysis after ischemic stroke.</p> <p><b>Methods:</b> We ...
Wahlgren, N., Luijckx, G-J, Sykora, M., Wahlgren, N,, Diedler, J., Diedler, Jennifer, Overgaard, Karsten, Overgaard, K., Diedler, J, Ringleb, Peter, Uyttenboogaart, M., Ford, G.A., Soinne, Lauri, Overgaard, K, Lees, K.R., Lees, KR, Sykora, M, Uyttenboogaart, M, Uyttenboogaart, Maarten, Ringleb, P., Ahmed, Niaz, Luijckx, G.J., Luijckx, Gert-Jan, Ahmed, N,, Ahmed, N., Lees, Kennedy R., Wahlgren, Nils, Ford, GA, Soinne, L, Soinne, L., Sykora, Marek, Ford, Gary A., Uyttenboogaart, Maarten; id_orcid   +32 more
core   +1 more source

Standardization of measurement and reporting of medication adherence using the TEN‐SPIDERS tool for claims data

British Journal of Clinical Pharmacology, EarlyView.
This study provides the first open‐source tool to implement the complete TEN‐SPIDERS framework in linked datasets for the determination of the PDC for medication adherence. The TEN‐SPIDERS tool enables transparent, reproducible medication adherence research through automated reporting of all calculation parameters and flexible customization options ...
Adam C. Livori, Tzu‐Yung Kuo, Jenni Ilomäki, Monique F. Kilkenny, Stella Talic, Zanfina Ademi, J. Simon Bell, Jedidiah I. Morton, Lachlan L. Dalli   +8 more
wiley   +1 more source

Applying machine learning to pharmacovigilance data: A proof‐of‐concept study

British Journal of Clinical Pharmacology, EarlyView.
Aim Machine learning (ML) applications in pharmacovigilance remain limited and underexplored. Using data from the French National pharmacovigilance database (FNPV), this proof‐of‐concept study aimed to assess the feasibility of using a ML algorithm—eXtreme Gradient Boosting (XGBoost)—combined with SHapley Additive exPlanations (SHAP) analysis, to ...
Romain Barus, Pauline Schiro, Jean‐Luc Faillie, Romane Freppel, Johana Béné, Claire de Canecaude, François Montastruc   +6 more
wiley   +1 more source

Antiplatelet Therapy for Acute Respiratory Distress Syndrome

Biomedicines, 2020
Acute respiratory distress syndrome (ARDS) is a common and devastating syndrome that contributes to serious morbidities and mortality in critically ill patients.
Chuan-Mu Chen, Hsiao-Ching Lu, Yu-Tang Tung, Wei Chen   +3 more
doaj   +1 more source

Mobile health interventions to improve adherence to oral anticoagulant treatment: A systematic review and critical analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Non‐adherence to oral anticoagulants (OACs) is associated with significant morbidity and mortality. Mobile health (mHealth) interventions have been used to improve medication adherence across the three phases of initiation, implementation and persistence.
Non Davies, Elin Haf Davies, Dyfrig A. Hughes   +2 more
wiley   +1 more source

To clot, or not to clot – Antithrombotic therapy is the question

South African Family Practice, 2019
Haemostasis and thrombosis rely on three components namely the vascular endothelial wall, blood platelets and the coagulation cascade. Non-physiologic excessive thrombosis occurs when haemostatic processes are dysfunctional, causing undue clot formation ...
E. Osuch, A. Marais
doaj   +1 more source

Exposure to CYP2C19‐metabolized drugs following acute stroke: A longitudinal cohort study to inform implementation of CYP2C19 genotype testing

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire, Andrew T. Lambarth, Ayesha Saleem, Daniel R. Burrage   +3 more
wiley   +1 more source