9-(4'-dimethylaminophenyl)-2,6,7-trihydroxy-xanthene-3-one is a potentially novel antiplatelet drug which antagonizes the effect of thromboxane A2 [PDF]
, 2018 Background: Currently, used oral antiplatelet drugs are both limited and associated with the risk of treatment failure/resistance. Research in this area is hence highly desired.
Applová, Lenka +8 more
core +1 more source
Antiplatelet therapy as an element of primary and secondary prevention of ischemic stroke
Медицинский совет, 2016 Antiplatelet medications are essential in the primary and secondary prevention of stroke. All currently available antiplatelet drugs are platelet aggregation inhibitors acting at various points of application, but they differ in their mechanism of action.
E. Y. Solovyova +2 more
doaj +1 more source
Aging-Related Decline of Glutathione Peroxidase 3 and Risk of Cardiovascular Events in Patients With Atrial Fibrillation [PDF]
, 2016 BACKGROUND: Experimental studies demonstrated that glutathione peroxidase 3 (GPx3), an antioxidant enzyme that catabolizes hydrogen peroxide, protects against thrombosis. Little is known about its role in cardiovascular disease. METHODS AND RESULTS:
Carnevale, Roberto +6 more
core +1 more source
Impact of Modifiable Bleeding Risk Factors on Major Bleeding in Patients With Atrial Fibrillation Anticoagulated With Rivaroxaban. [PDF]
, 2020 Background Reducing major bleeding events is a challenge when managing anticoagulation in patients with atrial fibrillation. This study evaluated the impact of modifiable and nonmodifiable bleeding risk factors in patients with atrial fibrillation ...
Amarenco, P +8 more
core +2 more sources
BMC Geriatrics, 2019 Background Little is known about the effects of continued antiplatelet therapy in patients who receive physician home visits. This study aimed to evaluate the association of survival with the continuation of antiplatelet drugs in patients who received ...
Yasuhiro Osugi +4 more
doaj +1 more source
NEW ANTIPLATELET DRUGS. PART 2
Рациональная фармакотерапия в кардиологии, 2016 Antiplatelet agents are a necessary component of modern therapy of atherosclerosis. The difficulties of the antiplatelet treatment lie in balance between the necessary therapeutic effect and the risk of excessive action, leads to the bleeding.
A. B. Sumarokov
doaj +1 more source
Frontiers in Pharmacology, 2023 Objectives: Long-term use of evidence-based antiplatelet therapy is recommended for management of stable coronary artery disease (SCAD). However, non-adherence to antiplatelet drugs is common in older patients.
Xiao Zou +8 more
doaj +1 more source
Efficacy of antiplatelet therapy in secondary prevention following lacunar stroke:Pooled analysis of randomized trials [PDF]
, 2015 Background and Purpose: Lacunar stroke accounts for ≈25% of ischemic stroke, but optimal antiplatelet regimen to prevent stroke recurrence remains unclear.
Benavente, Oscar R. +5 more
core +1 more source
National Journal of Physiology, Pharmacy and Pharmacology, 2019 Background: Cardiovascular disease is both highly prevalent and expensive to treat. Many novel anticoagulants, fibrinolytics, and antiplatelet agents have been found to be effective in decreasing the morbidity and mortality associated with cardiovascular
Deepak K R, Geetha A
doaj +1 more source
Multimodal interventions to enhance adherence to secondary preventive medication after stroke: a systematic review and meta-analyses [PDF]
, 2016 Summary: Introduction: Nonadherence to secondary preventative medications after stroke is common and is associated with poor outcomes. Numerous strategies exist to promote adherence.
Al AlShaikh, Sukainah +4 more
core +1 more source