Results 41 to 50 of about 8,789 (241)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations [PDF]

, 2022
Multiple resistance and pH adaptation (Mrp) cation/proton antiporters are essential for growth of a variety of halophilic and alkaliphilic bacteria under stress conditions.
Zickermann, V., Sharma, V., Altmeyer, A., Kühlbrandt, W. ; https://orcid.org/, Altmeyer, Anton, Zickermann, Volker, Sharma, Vivek, Lee, Y. ; https://orcid.org/, Haapanen, Outi, Lee, Yongchan, Kühlbrandt, Werner, Haapanen, O.   +11 more
core   +1 more source

Patched1 and Patched2 inhibit Smoothened non-cell autonomously

eLife, 2016
Smoothened (Smo) inhibition by Patched (Ptch) is central to Hedgehog (Hh) signaling. Ptch, a proton driven antiporter, is required for Smo inhibition via an unknown mechanism. Hh ligand binding to Ptch reverses this inhibition and activated Smo initiates
Brock Roberts, Catalina Casillas, Astrid C Alfaro, Carina Jägers, Henk Roelink   +4 more
doaj   +1 more source

Identification of the Causative Genes of Calcium Deficiency Disorders in Horticulture Crops: A Systematic Review

Agriculture, 2021
The occurrence of calcium (Ca2+) deficiency disorders is a severe problem in the production of horticulture crops. Recently, several studies have investigated the role of gene expression in Ca2+ deficiency disorders and/or Ca2+ accumulation, providing an
Takanori Kuronuma, Hitoshi Watanabe
doaj   +1 more source

About P systems with symport/antiport [PDF]

Soft Computing, 2004
It is proved that four membranes su±ce to P systems with minimal symport/antiport to generate all recursively enumerable sets of numbers. It is also proved that P systems with symport/antiport without maximal par- allelism are equivalent to partially blind counter automata.
openaire   +4 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting

Nature Communications, 2019
Cation-proton antiporters mediate selective ion exchange across cellular membranes to control pH, salt concentration and cell volume. Here the authors present a transition-path sampling method that overcomes the timescale gap between simulations (µs) and
Kei-ichi Okazaki, David Wöhlert, Judith Warnau, Hendrik Jung, Özkan Yildiz, Werner Kühlbrandt, Gerhard Hummer   +6 more
doaj   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Functional dissection of the proton pumping modules of mitochondrial complex I [PDF]

, 2011
Mitochondrial complex I, the largest and most complicated proton pump of the respiratory chain, links the electron transfer from NADH to ubiquinone to the pumping of four protons from the matrix into the intermembrane space. In humans, defects in complex
Zwicker Klaus, Nina Morgner, Esther Nübel, Radermacher, Michael, Lucie Sokolova, Dröse, Stefan, Stefan Kerscher, Zickermann, Volker, Brandt, Ulrich, Barth, Hans-Dieter, Nübel, Esther, Mirco Steger, Bernhard Brutschy, Stefan Dröse, Volker Zickermann, Brutschy, Bernd, Morgner, Nina, Stephanie Krack, Klaus Zwicker, Heide Heinrich, Brutschy Bernhard, Krack, Stephanie, Radermacher Michael, Heide, Heinrich, Hans-Dieter Barth, Ulrich Brandt, Zwicker, Klaus, Sokolova, Lucie, Steger Mirco, Michael Radermacher, Sokolova Lucie, Barth Hans-Dieter, Kerscher Stefan, Morgner Nina, Zickermann Volker, Nübel Esther, Kerscher, Stefan, Krack Stephanie, Steger, Mirco, Heinrich Heide, Brandt Ulrich, Dröse Stefan   +41 more
core   +2 more sources