Results 101 to 110 of about 181,112 (317)

Bayesian Meta-Analysis of Multiple Continuous Treatments: An Application to Antipsychotic Drugs [PDF]

arXiv, 2018
Modeling dose-response relationships of drugs is essential to understanding their effect on patient outcomes under realistic circumstances. While intention-to-treat analyses of clinical trials provide the effect of assignment to a particular drug and dose, they do not capture observed exposure after factoring in non-adherence and dropout.
arxiv  

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Clinical Pharmacology &Therapeutics, EarlyView.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund, Annette Haerdtlein, Wolfgang Fehrmann, Clara Weglage, Tobias Dreischulte, Ulrich Jaehde   +5 more
wiley   +1 more source

Antipsychotic Drugs: From Receptor-binding Profiles to Metabolic Side Effects

Current Neuropharmacology, 2017
Background: Antipsychotic-induced metabolic side effects are major concerns in psychopharmacology and clinical psychiatry. Their pathogenetic mechanisms are still not elucidated.
S. Siafis, D. Tzachanis, M. Samara, G. Papazisis   +3 more
semanticscholar   +1 more source

Diazonium Salts in Visible Light Photocatalysis – a Focused Overview of their Application in Continuous Flow Synthesis

ChemPhotoChem, EarlyView.
The combination of continuous flow technology and visible light photocatalysis has been used to improve the safety and productivity of reactions with diazonium salts as reactive intermediates. This approach has proven to be a reliable method for various organic synthesis routes with diazonium salts under mild and well‐defined conditions.
Christoph Deckers, Thomas H. Rehm
wiley   +1 more source

Further validation of the THINC‐it tool and extension of the normative data set in a study of n = 10.019 typical controls

International Journal of Methods in Psychiatric Research, Volume 31, Issue 4, December 2022., 2022
Abstract Introduction We report further validation and normative data for the THINC‐Integrated Tool (THINC‐it), a measure of cognitive function designed for use with individuals living with Major Depressive Disorder, but which is finding use in further psychiatric and neurological diseases. THINC‐it comprises four objective computerised cognitive tests
Maria Dalby, Peter Annas, 23andMe Research Team, John E. Harrison   +3 more
wiley   +1 more source

Examining the safety, efficacy, and patient acceptability of inhaled loxapine for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults

Neuropsychiatric Disease and Treatment, 2019
Justin Faden,1 Leslie Citrome21Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19125, USA; 2Psychiatry & Behavioral Sciences, New York Medical College, Valhalla, NY 10595, USAAbstract: Agitation is a common and serious symptom of ...
Faden J, Citrome L
doaj  

Human Genome data analyzed by an evolutionary method suggests a decrease in cerebral protein-synthesis rate as cause of schizophrenia and an increase as antipsychotic mechanism [PDF]

arXiv, 2001
The Human Genome Project (HGP) provides researchers with the data of nearly all human genes and the challenge to use this information for elucidating the etiology of common disorders. A secondary Darwinian method was applied to HGP and other research data to approximate and possibly unravel the etiology of schizophrenia.
arxiv  

Endogenous and Antipsychotic-Related Risks for Diabetes Mellitus in Young People With Schizophrenia: A Danish Population-Based Cohort Study.

American Journal of Psychiatry, 2017
OBJECTIVE Diabetes mellitus contributes to excessive cardiovascular deaths and reduced life expectancy in schizophrenia. This population-based cohort study investigated the endogenous risk for diabetes in antipsychotic-naive schizophrenia and evaluated ...
A. Rajkumar, H. T. Horsdal, T. Wimberley, D. Cohen, O. Mors, A. Børglum, C. Gasse   +6 more
semanticscholar   +1 more source

Antidepressants for social anxiety disorder: A systematic review and meta‐analysis

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 398-409, December 2022., 2022
Abstract Aim This systematic review is aimed to update and reintegrate the pharmacotherapy of social anxiety disorder (SAD), including the Japanese medical database. Methods We conducted a systematic review and meta‐analysis of pharmacotherapy of SAD according to the Medical Information Distribution Service.
Nobuyuki Mitsui, Yutaka Fujii, Satoshi Asakura, Hissei Imai, Hisashi Yamada, Naoki Yoshinaga, Yoshihiro Kanai, Takeshi Inoue, Eiji Shimizu   +8 more
wiley   +1 more source

Development of a Medication Monitoring System for an Integrated Multidisciplinary Program of Assertive Community Treatment (IMPACT) Team [PDF]

INNOVATIONS in Pharmacy, 2012
Purpose: The primary goal was to improve medication management oversight for a severely mentally ill (SMI) community-based population by developing a medication monitoring system based on current guidelines to optimize pharmacotherapy and minimize ...
Nicole B. Washington, DO, Assistant Professor, Nancy C. Brahm, PharmD, MS, BCPP, CGP, Clinical Professor, Bruce R. Winchester, PharmD Candidate, Sarah C. Watkins, PharmD Candidate   +3 more
doaj