Results 51 to 60 of about 195,206 (338)

A randomized-controlled trial with a Canadian electronic pill dispenser used to measure and improve medication adherence in patients with schizophrenia

Frontiers in Pharmacology, 2013
Objective: Medication adherence is extremely important in preventing relapse and lowering symptoms in schizophrenic patients. However, estimates show that nearly half of these patients have poor adherence. The Brief Adherence Rating Scale (BARS) seems to
Emmanuel eStip, Emmanuel eStip, Emmanuel eStip, Philippe D. Vincent, Philippe D. Vincent, Philippe D. Vincent, Catherine eGuevremont, Simon eZhornitsky, Constantin eTranulis, Constantin eTranulis, Constantin eTranulis, Juliette eSablier, Juliette eSablier   +12 more
doaj   +1 more source

A Review of Clinical Evaluation and Management of Delirium [PDF]

Journal of Clinical and Diagnostic Research, 2018
Delirium is a syndrome characterised by the acute onset, fluctuating course of disturbed consciousness and cognitive impairment. It is an important medical condition with poor outcomes.
Bhupendra Shah, Bijay Bartuala
doaj   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

Metabolic Syndrome Screening in Seriously Mentally Ill Patients: A Quality Improvement Project [PDF]

, 2016
A Project Submitted in Partial Fulfillment of the Requirements for the Degree of MASTER OF SCIENCE in Nursing ScienceSeriously mentally ill patients who are taking second-generation antipsychotics have a high risk of metabolic complications ...
Moreno, Annabel
core  

The longitudinal interplay between negative and positive symptom trajectories in patients under antipsychotic treatment: a post hoc analysis of data from a randomized, 1-year pragmatic trial [PDF]

, 2013
BACKGROUND: Schizophrenia is a highly heterogeneous disorder with positive and negative symptoms being characteristic manifestations of the disease. While these two symptom domains are usually construed as distinct and orthogonal, little is known about ...
Ascher-Svanum, H, Chen, L, Johnston, JA, Kinon, BJ, Marques, TR, Stauffer, V, Succop, P   +6 more
core   +2 more sources

Antipsychotics

Medicine, 2012
Antipsychotics are the mainstay of psychosis treatment. They are also used in the acute and long-term treatment of bipolar disorder, in depression and other conditions. They are classified as first-generation (‘typical’) and second-generation (‘atypical’) antipsychotics based on their ability to cause extrapyramidal symptoms (EPS).
openaire   +2 more sources

The synergistic effect of anticholinergic burden and depression on fall risk in older persons

British Journal of Clinical Pharmacology, EarlyView.
Aims Both anticholinergic burden (ACB) and depression are known to increase fall risk in older persons, next to increasing morbidity and mortality. However, the effect of depression on fall risk associated with ACB is unclear. This is relevant because several antidepressants have anticholinergic effects to some extent.
Raymond Salet, Nathalie van der Velde, Didi Rhebergen, Bob van de Loo, Lotta Seppala, Natasja M. van Schoor, Bruno Stricker, Marieke Henstra   +7 more
wiley   +1 more source

Deprescribing drugs with anticholinergic effects in older patients with increased risk of dementia in the multicomponent intervention study AgeWell.de

British Journal of Clinical Pharmacology, EarlyView.
Aim Drugs with anticholinergic effects are often considered as potentially inappropriate medications, especially for older patients, and deprescribing such drugs may improve cognitive function. The aim was to investigate the effectiveness of counselling on drug risks as part of a multimodal intervention to prevent cognitive decline. Methods The AgeWell.
Laura K. Lepenies, Hanna M. Seidling, Alexander Pabst, Melanie Luppa, Juliane Döhring, Martin Williamson, Thomas Frese, Jochen Gensichen, Wolfgang Hoffmann, Hanna Kaduszkiewicz, Hans‐Helmut König, Jochen René Thyrian, Birgitt Wiese, Steffi G. Riedel‐Heller, David Czock   +14 more
wiley   +1 more source

A tolerability burden index in schizophrenia: incorporating patient perspective in clinical trial adverse event reporting

Journal of Market Access & Health Policy, 2017
Background: Adverse event (AE) reporting in clinical trials does not fully capture the patient-level perspective and comparing tolerability across treatments or among studies is difficult.
Clément François, Alice Guiraud-Diawara, Christophe Lançon, Pierre Michel Llorca, Ann Hartry, Lene Hammer-Helmich, Djamel A. Zighed, Adrian Tanasescu, Mondher Toumi   +8 more
doaj   +1 more source

The impact of pimavanserin on psychotic phenotypes and tau phosphorylation in the P301L/COMT– and rTg(P301L)4510 mouse models of Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction Psychosis in Alzheimer's disease (AD) is associated with grave clinical consequences including a precipitous cognitive decline and a hastened demise.
Heidy Jimenez, Leslie Adrien, Adam Wolin, John Eun, Eric H. Chang, Ethan S. Burstein, Jesus Gomar, Peter Davies, Jeremy Koppel   +8 more
doaj   +1 more source