Results 61 to 70 of about 181,112 (317)
Association Between Antipsychotic Medication Use and Diabetes
Current Diabetes Reports, 2019 The prevalence of diabetes is 2–3-fold higher in people with severe mental illness than the general population. There are concerns that antipsychotics increase the risk of diabetes.
R. Holt
semanticscholar +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey +6 more
wiley +1 more source
Journal of Neuroscience Research, Volume 101, Issue 2, Page 263-277, February 2023., 2023 Substantia nigra (SN) hyperechogenicity, viewed with transcranial ultrasound, is a risk marker for Parkinson's disease. SN hyperechogenicity in healthy older adults is associated with changes in the excitability of specific motor cortical circuitry. These changes are unrelated to glutamate levels in the pre‐supplementary motor area (pre‐SMA).
Gabrielle Todd +18 more
wiley +1 more source
Molecules, 2023 The dopamine D2 receptor, which belongs to the family of G protein-coupled receptors (GPCR), is an important and well-validated drug target in the field of medicinal chemistry due to its wide distribution, particularly in the central nervous system, and ...
Piotr Stępnicki +12 more
doaj +1 more source
Journal of Alzheimer's disease reports, 2018 It is almost ten years since the Banerjee 2009 report established that inappropriate prescribing of antipsychotics in the elderly was occurring in the UK and such patients had an 85% increased risk of adverse events and greater mortality. This report was
S. Ralph, A. Espinet
semanticscholar +1 more source
Animal Models and Experimental Medicine, EarlyView.Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao +6 more
wiley +1 more source
Frontiers in PsychiatryBackgroundMost genetic analyses that have attempted to identify a locus or loci that can distinguish patients with treatment-resistant schizophrenia (TRS) from those who respond to treatment (non-TRS) have failed.
Masanobu Kogure +28 more
doaj +1 more source
Designing drug regimens that mitigate nonadherence [PDF]
arXiv, 2021 Medication adherence is a well-known problem for pharmaceutical treatment of chronic diseases. Understanding how nonadherence affects treatment efficacy is made difficult by the ethics of clinical trials that force patients to skip doses of the medication being tested, the unpredictable timing of missed doses by actual patients, and the many competing ...
arxiv
World Psychiatry, 2017 Antipsychotic polypharmacy in schizophrenia is much debated, since it is common and costly with unclear evidence for its efficacy and safety. We conducted a systematic literature search and a random effects meta‐analysis of randomized trials comparing ...
B. Galling +12 more
semanticscholar +1 more source
Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease
Annals of Neurology, EarlyView.Objective The objective of this study was to investigate the differences in cyclic alternating patterns (CAP) metrics, a non‐rapid eye movement (NREM) sleep physiological rhythm, among recently diagnosed patients with Parkinson's disease (PD), and individuals at high and low risk for developing PD based on genetic and prodromal risk.
Andrew Dagay +5 more
wiley +1 more source