Results 141 to 150 of about 3,371,263 (384)

Bipolar Disorder as a Long‐Term Risk Factor for Parkinson's Disease: A Nationwide Case–Control Study

open access: yesMovement Disorders, EarlyView.
Abstract Background Previous studies suggest an association between bipolar disorder (BD) and an increased risk of Parkinson's disease (PD), but the long‐term temporal relationship remains unclear. Particularly, it is unclear whether the risk of PD is influenced by the duration since BD diagnosis.
Elina Jaakkola   +5 more
wiley   +1 more source

Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes

open access: yesObesity, EarlyView.
ABSTRACT Objective The real‐world evidence on the association between glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and cancer risk remains limited and mixed. Methods In 2013–2020 national Medicare claims data, we included cancer‐naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP‐1 RA, sodium‐glucose cotransporter 2
Ying Lu   +13 more
wiley   +1 more source

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

open access: yesChemistryOpen, EarlyView.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye   +2 more
wiley   +1 more source

Effect of Testosterone Therapy on Cytochrome P450 3A and P‐Glycoprotein Activities Using Midazolam and Digoxin as Probe Substrates Among Transgender Adults

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT Background Gender‐affirming testosterone therapy is one part of the standard of care for more than 1 million transgender adults in the United States. Testosterone therapy may influence the activities of drug‐metabolizing enzymes and transporters, but knowledge about its effect on the pharmacokinetics of other medications is limited.
Michiko Hunter   +9 more
wiley   +1 more source

A systematic review using the Theoretical Domains Framework to identify barriers and facilitators to the adoption of prescribing guidelines

open access: yesInternational Journal of Pharmacy Practice, EarlyView., 2020
Abstract Objectives Evidence‐based guidelines have the potential to reduce variation and increase prescribing quality. Identifying the key determinants to their uptake, using a theory‐based approach, may assist in the design of successful interventions to increase their adoption into practice.
Paulina Paksaite   +4 more
wiley   +1 more source

Recent Advances in Metal‐Based Catalysts for Nitrile Hydration to Amides: Mechanistic Aspects

open access: yesThe Chemical Record, EarlyView.
Amide vital functional group plays a key role in the composition of amide‐containing compounds, including peptides, proteins, and amino acids. Demand for innovative amide derivatives grows due to their crucial role in drug development. A cost‐effective method uses metal‐catalyzed hydration of nitriles to amides.
Fatima‐Ezzahraa Essebbar   +3 more
wiley   +1 more source

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