Results 131 to 140 of about 32,966 (252)

Nurse‐Led Telephonic Care Following Emergency Department Visits for Persons Living With Dementia and Their Care Partners: A Program Description

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Most visits to the emergency department (ED) by persons living with dementia (PLWD) who are then discharged back into the community are preventable. However, care partners and other caregivers of the over 6 million PLWD residing in the United States lack the supports, services and timely access to clinical care to address many common needs in ...
Valerie T. Cotter, Corita R. Grudzen, Janessa Griffith, Allison Cuthel, Afshana Hoque, Alicia I. Arbaje, Cameron J. Gettel, Aditi Durga, Ariana Emami, Keith Goldfeld, Joshua Chodosh, Manish N. Shah, Abraham A. Brody, ED‐LEAD Investigators, Lauren Abbate, Rebecca Anthopolos, Fernanda Bellolio, Jonathan Berkowitz, Andrea Blome, Erik Jonathan Blutinger, Justin Kenneth Brooten, Reed Caldwell, Christopher Caspers, Nathaniel Chin, Edward Cisek, Jeremy Thomas Cushman, Dan David, Allison L. Ducharme‐Smith, Scott Dresden, Mary Ellen Dupont, Marie Carmelle Elie, Andra Farcas, Bucky Ferozan, Jori Fleisher, Nicholas Genes, Andrea Gilmore‐Bykovski, Scott Goldberg, Elizabeth Goldberg, Satheesh Gunaga, Heather Heaton, Courtney Jones, Maura Kennedy, Timmy Li, Joseph Miller, Brian Mittman, Kei Ouchi, Jennifer Portz, Alex Quinones, Suzanne Ryer, Ashley Shreves, Michelle Simpson, Silas Smith, Payal Sud, Joe Suyama, Scotty Thomas, Victoria Vaughan Dickson, Brian W. Patterson, Ian Wittman, Nancy Wood   +58 more
wiley   +1 more source

Exploring Current Emergency Medical Services Approaches to Manage Agitated Older Adult Patients: An Analysis of Statewide Protocols

Journal of the American Geriatrics Society, EarlyView.
Most state EMS protocols provide guidance on management of agitated patients, including use of physical restraints and chemical sedatives, yet older adult‐specific modifications or dosing guidance are uncommon. ABSTRACT Background Agitation in older adults presents unique challenges for emergency medical services (EMS) clinicians.
Joshua Lachs, Rana Barghout, William Haussner, David Hancock, Emily Benton, Maia Dorsett, Gregory Peters, Rebecca Cash, Joseph Holley, Tony Rosen   +9 more
wiley   +1 more source

Substitution Patterns After Discontinuation of CNS‐Active Medications in Older Adults in Primary Care

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Little is known about substitution of alternative medications in the context of deprescribing. The objectives were to: (1) determine the frequency of medication substitutions among those who discontinued a central nervous system (CNS)‐active medication, and (2) characterize substitutions as potentially inappropriate (as per the 2023
Shelly L. Gray, Annalisa V. Piccorelli, Laura A. Hart, Andrea J. Cook, Brian D. Williamson, Benjamin H. Balderson, Elizabeth A. Phelan   +6 more
wiley   +1 more source

Antibacterial activity of antipsychotic agents, their association with lipid nanocapsules and its impact on the properties of the nanocarriers and on antibacterial activity. [PDF]

PLoS One, 2018
Nehme H, Saulnier P, Ramadan AA, Cassisa V, Guillet C, Eveillard M, Umerska A.   +6 more
europepmc   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Drug‐Induced Sialolithiasis—A Big‐Data Retrospective Study

Oral Diseases, EarlyView.
ABSTRACT Background Sialolithiasis pathophysiology is multifactorial, with systemic medications often hypothesised as a key contributor, particularly in older adults (Drug‐Induced Sialolithiasis). However, robust evidence supporting this theory is limited.
Gal Avishai, Gil Caspi, Akhilanand Chaurasia, Gavriel Chaushu, Daya Masri, Ehud Jonas   +5 more
wiley   +1 more source

Adverse outcomes between VMAT2 and anticholinergics in tardive dyskinesia: A target trial emulation

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Vesicular monoamine transporter 2 (VMAT2) inhibitors have been approved for the treatment of tardive dyskinesia (TD), whereas anticholinergic agents are still widely used for this condition. This study aimed to compare the risk of major clinical adverse outcomes among patients with TD treated with VMAT2 inhibitors versus anticholinergic agents ...
Tien‐Wei Hsu, Chih‐Wei Hsu, Ping‐Tao Tseng, Yi‐Ya Fang, Chuo‐Yu Lee, Yu‐Hsuan Lin, Brendon Stubbs, Trevor Thompson, Andre F. Carvalho, Yu‐Chen Kao, Jen‐Ping Chen, Fu‐Chi Yang, Chia‐Kuang Tsai, Chih‐Sung Liang   +13 more
wiley   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Psychotropic medication and the fetal brain

The Journal of Physiology, EarlyView.
Abstract figure legend Brain region changes linked to in‐utero psychotropic exposure. Abstract Medications known to cross the blood–brain barrier (psychotropic medications) are commonly prescribed to women during pregnancy, often for the management of mental illness.
Oliver Gale‐Grant, Tomoki Arichi
wiley   +1 more source

Advances in Human Mass Balance Studies: An IQ Consortium Perspective on Current Practices and Emerging Trends

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.
Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer, Ellen Cannady, Filip Cuyckens, Ulrike Glaenzel, Camille Granvil, Felix Huth, Alexander D. James, Wenying Li, Céline Veau, Graeme Young, Qin Yue, Gregory S. Walker, Upendra A. Argikar, Jonathan N. Bauman, Cathy Cantalloube, Yu‐Luan Chen, Ping Kang, Patricia Moliner, Mette L. Pedersen, Isabel Piel, Simone Schadt, Hanno Schieferstein, Julia Suchomel, Shuai Wang, S. Cyrus Khojasteh   +24 more
wiley   +1 more source