Results 171 to 180 of about 31,996 (301)

The use of different types of networks, alone and in combination, for drug target identification

British Journal of Pharmacology, EarlyView.
Current therapeutic approaches often focus on targeting clinical symptoms or peripheral phenotypes rather than the underlying molecular mechanisms, or endophenotypes, that drive diseases. While symptom‐based drugs can alleviate discomfort, they do not necessarily alter disease progression and may overlook opportunities for prevention or early ...
Paolo Parini
wiley   +1 more source

Interaction Between anti-Alzheimer’s Disease Drugs and Antipsychotic Agents in the Treatment of Behavioral and Psychological Symptoms: Extrapyramidal Side Effects

, 2022

openalex   +1 more source

Advancing the measurement of psychotherapy outcomes for youth with irritability using in vivo ecological momentary assessment: an exploratory observational study

Child and Adolescent Mental Health, EarlyView.
Background Ecological momentary assessment (EMA) can reveal naturalistic within‐person changes in symptoms and behaviors, essential for examining psychotherapy's effectiveness. However, no prior study has leveraged EMA to assess real‐time, naturalistic changes of clinical symptoms during psychotherapy in youth with clinically impairing irritability ...
Reut Naim, Urmi Pandya, Shannon Shaughnessy, Ramaris E. German, Lauren M. Henry, Katharina Kircanski, Melissa A. Brotman   +6 more
wiley   +1 more source

Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents [PDF]

, 2017
Tomomi Sanomachi, Shuhei Suzuki, Kenta Kuramoto, Hiroyuki Takeda, Hirotsugu Sakaki, Keita Togashi, Shizuka Seino, Takashi Yoshioka, Masashi Okada, Chifumi Kitanaka   +9 more
openalex   +1 more source

Treatment Journey From Diagnosis to the Successful Implementation of a Long-Acting Injectable Antipsychotic Agent in Young Adults With Schizophrenia

, 2023
John M. Kane, Marko A. Mychaskiw, Sangtaeck Lim, Mark Suett, Marc Tian, José M. Rubio   +5 more
openalex   +2 more sources

Incidence of Autoimmune Diseases in 30,340 Danish Women With Polycystic Ovary Syndrome (PCOS) Compared to 151,520 Controls. A National Cohort Study

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Autoimmunity can be part of the pathogenesis of polycystic ovary syndrome (PCOS), but prospective studies on autoimmune disease in population based cohorts are lacking. This study aimed to investigate incidence rates of autoimmune disease in Danish women with PCOS before and after PCOS diagnosis compared to controls.
Dorte Glintborg, Jens‐Jakob Kjer Møller, Katrine Hass Rubin, Louise Lehmann Christensen, Marianne Skovsager Andersen   +4 more
wiley   +1 more source

Risk of depression with GLP‐1 receptor agonists use in overweight or obese adults with type 2 diabetes: A new‐user, active‐comparator cohort study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims The association between glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and depression remains uncertain due to contradictory evidence. We compared the risk of incident depression between GLP‐1 RAs and sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) in overweight or obese adults with type 2 diabetes.
Yu Chang, Ming‐Hong Hsieh, Po‐Chung Ju, Cheng‐Chen Chang   +3 more
wiley   +1 more source

Body mass index and mental disorders: A Danish cohort study

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Low and high body weight present significant global health challenges and may be linked to specific mental disorders. Thus, we aimed to examine the associations between body mass index (BMI) and specific mental disorders. Materials and Methods In this Danish, population‐based cohort study using questionnaire and registry data, we included
Sigrid Bjerge Gribsholt, Kristina Laugesen, Oleguer Plana‐Ripoll, Sinna Pilgaard Ulrichsen, Mogens Vestergaard, Bjørn Richelsen, Ola Ekholm, Henrik Toft Sørensen   +7 more
wiley   +1 more source

PMH44 COST AND EFFECTIVENESS OF FLUPENTIXOL COMPARED TO OTHER FIRST AND SECOND GENERATION ANTIPSYCHOTIC AGENTS FOR THE TREATMENT OF SCHIZOPHRENIA IN ROUTINE CARE

, 2009
Tom Stargardt, CA Gericke, Georg Juckel
openalex   +1 more source

Presence of interictal epileptiform EEG discharges implies increased risk of recurrence after the first unprovoked seizure: Report of the International League Against Epilepsy and International Federation of Clinical Neurophysiology

Epilepsia, EarlyView.
Abstract Objective A joint International Federation of Clinical Neurophysiology–International League Against Epilepsy (IFCN‐ILAE) Taskforce was created to explore the published evidence for initial EEG recordings in the evaluation of patients who experienced their first unprovoked seizure, and to determine the diagnostic value of EEG in supporting the ...
Betül Baykan, John Dunne, Samuel Wiebe, Louis Maillard, Sandor Beniczky, Michalis Koutroumanidis, Margitta Seeck   +6 more
wiley   +1 more source