A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres +13 more
wiley +1 more source
Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele +7 more
wiley +1 more source
High Adherence to Pharmacological Treatment Guidelines in Recovery and Remission States Among Patients With Schizophrenia: A Cross-Sectional Study. [PDF]
Asada R +4 more
europepmc +1 more source
Learning Outcomes That Maximally Differentiate Psychiatric Treatments
ABSTRACT Objectives To develop a statistical method that uncovers clinically meaningful differences between active psychiatric treatments, even when traditional rating scales fail to do so. Methods We introduce Supervised Varimax (SV), a novel algorithm that transforms individual items from clinical rating scales into a small set of optimized outcomes ...
Eric V. Strobl, Semmie Kim
wiley +1 more source
Antidepressant Augmentation of Antipsychotic Treatment in Schizophrenia: A Narrative Review. [PDF]
Li W +7 more
europepmc +1 more source
Pharmacoepidemiology of antipsychotic utilization among children and adolescents in Montevideo between 2018 and 2022. [PDF]
Cabral S +4 more
europepmc +1 more source
A meta-analysis of the incidence proportion of obesity and associated risk factors in patients with schizophrenia. [PDF]
Long J, Yang B, Zheng Q.
europepmc +1 more source
Vitamin D Adequacy Conditions the Prolactin-Suppressive Effect of Metformin in Men Receiving Prolactin-Elevating Medications. [PDF]
Krysiak R +4 more
europepmc +1 more source
Recognizing and Mitigating the Effects of Medication on Heat-Related Illness in Older Adults: A Scoping Review. [PDF]
Tews LM +4 more
europepmc +1 more source

