Results 181 to 190 of about 3,371,263 (384)

Erratum to The importance of dopamine D4 receptors in the action and development of antipsychotic agents [PDF]

, 1996
Gavin P. Reynolds
openalex   +1 more source

The use of different types of networks, alone and in combination, for drug target identification

British Journal of Pharmacology, EarlyView.
Current therapeutic approaches often focus on targeting clinical symptoms or peripheral phenotypes rather than the underlying molecular mechanisms, or endophenotypes, that drive diseases. While symptom‐based drugs can alleviate discomfort, they do not necessarily alter disease progression and may overlook opportunities for prevention or early ...
Paolo Parini
wiley   +1 more source

Cost-Effectiveness of Long-Acting Risperidone Injection versus Alternative Atypical Antipsychotic Agents in Patients with Schizophrenia in China

, 2009
Li Yang, Ming Li, Tao Libo, Mingliang Zhang, M. Deborah Nicholl, Peng Dong   +5 more
openalex   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Binding properties of MS-377, a novel antipsychotic agent, to rat brain membranes

, 2000
Jun-ichi Karasawa, Shinji Takahashi, Kazutoshi Horikomi   +2 more
openalex   +1 more source

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

Modafinil Augmentation of Atypical Antipsychotic Agents: Duplicate Publication, Self-plagiarism, Salami Publication, and Other Matters

, 2016
Girish Banwari, Sagar Karia, S. Avudaiappan, Harish M Tharayil, Chittaranjan Andrade   +4 more
openalex   +1 more source

Regulation of P-glycoprotein expression in brain capillaries in Huntington’s disease and its impact on brain availability of antipsychotic agents risperidone and paliperidone [PDF]

, 2015
Yu-Han Kao, Yijuang Chern, Huiting Yang, Huimei Chen, Chun‐Jung Lin   +4 more
openalex   +1 more source

Protocol on to Assess the Effectiveness of Planned Teaching on Knowledge Regarding to Adverse Effect of Antipsychotic Agents among Caregivers of Schizophrenia Patient

, 2021
Deepti Ekhar, Pooja Kasturkar, Jaya Gawai   +2 more
openalex   +2 more sources

Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.

New England Journal of Medicine, 2005
J. Lieberman, T. Stroup, J. McEvoy, J. McEvoy, M. Swartz, R. Rosenheck, D. Perkins, R. Keefe, S. Davis, C. E. Davis, B. Lebowitz, J. Severe, J. Hsiao   +12 more
semanticscholar   +1 more source