British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Whereas biased agonism on the 5‐HT2A receptor has been ascribed to hallucinogenic properties of psychedelics, no information about biased inverse agonism on this receptor is available. In schizophrenia, increased 5‐HT2A receptor constitutive activity has been suggested, highlighting the therapeutic relevance of inverse ...
Itziar Muneta‐Arrate +4 more
wiley +1 more source
Chemoinformatic studies on some inhibitors of dopamine transporter and the receptor targeting schizophrenia for developing novel antipsychotic agents. [PDF]
Heliyon, 2020 Olasupo SB +3 more
europepmc +1 more source
Synthesis and Pharmacological Studies for New Benzotriazole and Dibenzodiazepine Derivatives as Antipsychotic Agents [PDF]
, 2009 Osama I. El‐Sabbagh, Sameh El-Nabtityt
openalex +1 more source
Differential G protein activation by the long and short isoforms of the dopamine D2 receptor
British Journal of Pharmacology, EarlyView.Background and Purpose The dopamine D2 receptor is expressed as a short (D2S) and a long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S isoform shows higher presynaptic expression than the D2L isoform, and decreased D2S expression has recently been linked to an increased risk for schizophrenia.
David Reiner‐Link +4 more
wiley +1 more source
The pharmacist’s response to the needs of patients undergoing treatment with psychotropic medication [PDF]
, 1999 The usage of psychotropic (Table 1) medication is considerable world wide. In Malta, this can be attested to by the numerous studies that have been conducted by the University of Malta Department of Pharmacy (in conjuction with other institutions and ...
Sant Fournier, Mary Ann
core
Binding properties of MS-377, a novel antipsychotic agent, to rat brain membranes
, 2000 Jun-ichi Karasawa +2 more
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ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Antipsychotic agents deteriorate brain and retinal function in schizophrenia patients with combined auditory and visual hallucinations: A pilot study and secondary follow-up study. [PDF]
Brain Behav, 2020 Zhuo C +10 more
europepmc +1 more source
Pharmacological characteristics of perospirone hydrochloride, a novel antipsychotic agent.
, 2000 Yukihiro Ohno
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Erratum to: Costs and effects of paliperidone extended release compared with alternative oral antipsychotic agents in patients with schizophrenia in Greece: a cost effectiveness study [PDF]
, 2009 Maria Geitona +5 more
openalex +1 more source