Results 41 to 50 of about 8,379,610 (258)

Identification of serodiscordant couples, their clinical and laboratory characteristics, and vulnerabilities of HIV transmission risk in Northeastern Brazil in the era of pre-exposure prophylaxis (PrEP)

Revista Ciências em Saúde, 2020
Objectives: To evaluate the frequency of HIV serodiscordants couples and their seronegative partners who were candidates for pre-exposure prophylaxis (PrPE), and the knowledge about behavioural measures to reduce virus transmission. Methods: The research
Maíra Gomes Monteiro, Adriana Farrant Braz, Kledoaldo Lima, Heloísa Ramos Lacerda   +3 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Predictors of immunological failure after initial response to highly active antiretroviral therapy in HIV-1-infected adults: A EuroSIDA study [PDF]

, 2004
BACKGROUND: Factors that determine the immunological response to highly active antiretroviral therapy (HAART) are poorly defined. OBJECTIVE: Our aim was to investigate predictors of immunological failure after initial CD4(+) response.
Horban, A, Mocroft, Amanda, Dragsted, Ulrik Bak, Vella, S, Viard, JP, Lundgren, JD, Vella, Stefano, Viard, Jean-Paul, Machala, Ladislav, Hansen, ABE, Panos, G, Horban, Andrzej, Panos, George, Dragsted, UB, Lundgren, Jens Dilling, Mercey, D, Mocroft, A, Hansen, Ann-Britt E, Machala, L, Mercey, Danielle   +19 more
core  

Self-Initiation of Antiretroviral Therapy in the Developing World: the Involvement of Private Pharmacies in an HIV Program. [PDF]

, 2012
Self-initiation to antiretroviral treatment (ART) exposes the patient to the risk of drug toxicity, poor adherence to treatment, and escalates the development of drug resistance.
Buma, Deus, Minzi, Omary Mashiku, Kagashe GA, Buma, D., Minzi OM, Buma D, Kagashe, G.A., Kagashe, Godeliver A, Minzi, O.M.   +8 more
core   +1 more source

Disseminated kaposi's sarcoma in an HIV-positive patient: A rare entity in an Indian patient

Indian Journal of Dermatology, 2016
AIDS-associated disseminated Kaposi sarcoma (KS) is a rare entity, especially in India due to the low prevalence of human herpes virus-8 infections in Indian population.
Biswanath Behera, Laxmisha Chandrashekar, Devinder Mohan Thappa, Pampa Ch Toi, Kolar Vishwanath Vinod   +4 more
doaj   +1 more source

Diarrhea and AIDS in the Era of Highly Active Antiretroviral Therapy [PDF]

Clinical Infectious Diseases, 1999
severe malnutrition, low-grade fever with night sweats, and, finally, a wasting away followed by death. Although multiple illness in HIV-infected patients. parasites, pathogenic bacteria, and, occasionally, viruses have been isolated from the stool of up to two-thirds of patients with AIDS, pathogen-specific therapy has generally been only Causes of ...
M, Kartalija, M A, Sande
openaire   +2 more sources

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Time to undetectable viral load after highly active antiretroviral therapy initiation among HIV-infected pregnant women [PDF]

, 2007
Background. There have been no clinical trials in resource-rich regions that have addressed the question of which highly active antiretroviral therapy (HAART) regimens are more effective for optimal viral response in antiretroviral-naive, human ...
Patel, D, European Collaborative Study
core  

Long-term use of first-line highly active antiretroviral therapy is not associated with carotid artery stiffness in human immunodeficiency virus-positive patients

Brazilian Journal of Infectious Diseases, 2014
Objective: To evaluate whether or not highly active antiretroviral therapy is associated with carotid artery stiffness in human immunodeficiency virus-positive patients in Henan Province, China.
Haohui Zhu, Jianjun Yuan, Yisa Wang, Fan Gao, Xiao Wang, Changhua Wei, Jiyun Chen, Xiaohui Fan, Mei Zhang   +8 more
doaj   +1 more source