Results 81 to 90 of about 101,157 (242)

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

Beyond Standard Half‐Life: Real‐world Pharmacokinetics of Efanesoctocog Alfa in a Single Centre

Haemophilia, EarlyView.
ABSTRACT Introduction Efanesoctocog alfa (EFA) is an ultra–extended half‐life factor VIII (FVIII) developed to address limitations of conventional prophylaxis in haemophilia A. Although the XTEND trials reported low interindividual pharmacokinetic (PK) variability, real‐world data remain important to better characterize PK profiles across patient ...
Laurent Sattler, Agathe Herb, Léa Pierre, Jordan Wimmer, Manon Dolt, Olivier Feugeas, Dominique Desprez   +6 more
wiley   +1 more source

Understanding the implementation of patient navigation for adults living with HIV: A scoping review of components, equity considerations and lessons learned

HIV Medicine, EarlyView.
Abstract Background People living with HIV navigate complex medical and social challenges that impact engagement in care, including stigma, poverty and systemic inequities. Patient navigation has emerged as a promising approach to improve linkage, retention and adherence across the HIV care continuum.
Kristina M. Kokorelias, Christine L. Sheppard, Andrew Eaton, Marina B. Wasilewski, Sander L. Hitzig, Dean Valentine, Mackenzie Earle, Carolina Navas, David Gerstle, Maurita T. Harris, Luxey Sirisegaram   +10 more
wiley   +1 more source

Missed opportunities to prevent HIV acquisition with pre‐exposure prophylaxis: A mixed methods study of people with recently acquired HIV in the United Kingdom

HIV Medicine, EarlyView.
Abstract Objectives To explore missed opportunities for PrEP use among people with recently acquired HIV in the United Kingdom. Methods Data were derived from CASCADE, an international, longitudinal, mixed‐methods study of adults (≥16 years) with recently acquired HIV (≤12 months).
Argyro Karakosta, Emily Jay Nicholls, Flavien Coukan, Diarmuid Nugent, Iain Reeves, Laura Waters, Sarah Fidler, Elisa Ruiz Burga, Julie Fox, Alison Uriel, Jane Nicholls, Claire Mackintosh, Shema Tariq, Fiona Burns, for CASCADE Collaboration, John Gill, Kholoud Porter, Fiona Burns, Christina Carlander, Rafael Eduardo Campo, Harmony Garges, Sophie Grabar, Inma Jarrín, Laurence Meyer, Moustafa Kamel, Shema Tariq, Giota Touloumi, Marc van der Valk, Vani Vannappagari, Alain Volny Anne, Linda Wittkop, Lital Young, Agnes Aisam, Diana Barger, Eli Fitzgerald, Argyro Karakosta, Emily Jay Nicholls, Nicoletta Policek, Bruno Spire, Inés Suárez‐García, Sophie Abgrall, Valerie Andriantsoanirina, Veronique Avettand‐Fenoel, Christine Bourgeois, Marie‐Laure Chaix, Antoine Cheret, Hugues Fischer, Cecile Goujard, Caroline Lascoux‐Combe, Annie Le Palec, Ventzlislava Petrov‐Sanchez, Asier Saez‐Cirion, Remonie Seng, Karl Stefic, Josephine Tine, E Piet, A Gagneux‐Brunon, C Jacomet, L Piroth, F Benezit, M Goussef, P Tattevin, F Bani Sadr, I Lamaury, M Nacher, H Bazus, O Robineau, R Calin, C Katlama, JL Meynard, B Denis, J Ghosn, V Joly, MA Khuong, F Caby, E Rouveix Nordon, P de Truchis, S Abgrall, A Chéret, C Duvivier, A Becker, P Miailhes, S Abel, G Unal, A Makinson, G Martin‐Blondel, A Morisot, S Bregigeon, C Allavena, V Rabier, H Fischer, L Vallet, L Marchand, T Saïdi, D Costagliola, S Grabar, Pierre Tattevin, Pierre de Truchis, M Hughes Fischer, Santiago Moreno, David Dalmau, M Luisa Navarro, M Isabel González, Federico Garcia, Eva Poveda, Félix Gutiérrez, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, M Ángeles Muñoz‐Fernández, G. Adamis, M. Chini, G. Chrysos, M. Marangos, O. Katsarou, D. Kofteridis, S. Metallidis, P. Panagopoulos, N. Pantazis, A. Papadopoulos, V. Paparizos, V. Papastamopoulos, M. Psychogiou, H. Sambatakou, NV. Sipsas, G. Touloumi, C Thomadakis, Julie Fox, Louise Terry, Alison Uriel, Sarah Fidler, Wilbert Ayap, Laura Waters, Fowsiya Nur, Sabine Kinloch, Thomas Fernandez, Diarmuid Nugent, Javier Pinedo, Iain Reeves, Lidia Ignatov, Tracy Fong, Laura Cunningham, Jaydee Pangan, Claire Mackintosh, Louise Sharp   +145 more
wiley   +1 more source

Scaling HIV self‐testing to improve health equity among cisgender gay, bisexual and other men who have sex with men, trans and gender‐diverse people in the United Kingdom: An HIV self‐testing implementation action framework

HIV Medicine, EarlyView.
Abstract Background HIV self‐testing (HIVST) is feasible, highly acceptable and can increase HIV testing uptake/frequency without harm while also reducing costs. Despite HIVST's benefits, UK service provision has been sporadic partially due to policymakers and commissioners' reluctance over concerns about linkage to care/surveillance, which ultimately ...
T. Charles Witzel, Peter Weatherburn, Fiona M. Burns, Isaac Y.‐H. Chu, Phil Samba, Alison J. Rodger   +5 more
wiley   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Focus on chirality of HIV-​1 non-​nucleoside reverse transcriptase inhibitors [PDF]

, 2016
Chiral HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of great interest since one enantiomer is often more potent than the corresponding counterpart against the HIV-1 wild type (WT) and the HIV-1 drug resistant mutant strains.
Famiglini, Valeria, Silvestri, Romano
core   +2 more sources

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

A reduced dose of darunavir/ritonavir is effective in PI-experienced HIV-infected patients

Brazilian Journal of Infectious Diseases
Darunavir (DRV) is an HIV-1 protease inhibitor that is used together with a low boosting dose of ritonavir as part of an antiretroviral therapy (ART) regimen in treatment-experienced and naïve HIVpositive patients.
Massimiliano Lanzafame, Stefano Bonora, Emanuela Lattuada, Andrea Calcagno, Sandro Vento   +4 more
doaj   +1 more source

Assessment of quality of life in a cohort of newly diagnosed patients on haart regimen, in resource restricted tribal region of chhattisgarh, India: A prospective study

Journal of Global Infectious Diseases, 2013
Background: Highly active antiretroviral therapy regimens have resulted in the systemic/clinical healing for human immune deficiency virus-infected patients but the consequence of antiretroviral therapy on the whole quality of life has become a major ...
Harminder Singh, Kamalpreet Kaur, Navin Dulhani, Akash Bansal, Bithika N Kumar, Vinod Kumar Singh Chouhan   +5 more
doaj   +1 more source