Results 21 to 30 of about 259,590 (298)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Optimizing resources to reduce costs to determine HIV viral load in limited resources settings

Biomédica: revista del Instituto Nacional de Salud, 2017
Introduction: HIV viral load testing is a key factor to evaluate the accomplishment of the UNAIDS target of 90% of viral suppression among people receiving antiretroviral therapy.
Amalia Girón-Callejas, Ricardo Mendizabal-Burastero, Elizabeth Yax, Axel Martínez, Carlos Mejía-Villatoro   +4 more
doaj   +1 more source

A case report of clinical implications of a delayed antiretroviral therapy switch in a patient with multiple treatment interruptions

SAGE Open Medical Case Reports, 2022
The Namibia national antiretroviral therapy guidelines recommend that patients living with HIV who interrupt antiretrovirals and in the process disengage from care be restarted on their usual antiretroviral therapy regimen upon return.
Mireille A Mpalang Kakubu, Kandali Frans, Nelson Gibutai, Patrick DMC Katoto   +3 more
doaj   +1 more source

Challenges and Opportunities for the Implementation of Virological Testing in resource-limited settings [PDF]

, 2012
Though the advantages of routine virological monitoring for patients on anti-retroviral therapy have been established, cost and complexity limit its full implementation.
Bartlett, Department of Health and Human Services, Emmanuel Fajardo, Hamers, Hamers, Helen Bygrave, Jani, Kerschberger, Laurent, Murtagh, Médecins Sans Frontières, Médecins Sans Frontières, Nathan Ford, Orrell, Orrell, Orrell, Oyomopito, Teri Roberts, UNAIDS, Médecins Sans Frontières, World Health Organization, World Health Organization, World Health Organization, World Health Organization, UNAIDS   +22 more
core   +3 more sources

Agreement between physicians and non-physician clinicians in starting antiretroviral therapy in rural Uganda

Human Resources for Health, 2009
Background The scarcity of physicians in sub-Saharan Africa – particularly in rural clinics staffed only by non-physician health workers – is constraining access to HIV treatment, as only they are legally allowed to start antiretroviral therapy in the ...
Vasan Ashwin, Kenya-Mugisha Nathan, Seung Kwonjune J, Achieng Marion, Banura Patrick, Lule Frank, Beems Megan, Todd Jim, Madraa Elizabeth   +8 more
doaj   +1 more source

Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options [PDF]

, 2011
Article approval pendingDrug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence of HIV-1 isolates that preferentially use CXCR4 as a coreceptor for cell
Ashika Singh, Bjorndal, Brenner, Briggs, Briz, Cann, Cecilia, Cilliers, Coakley, Coetzer, Connor, Cozzi-Lepri, Daniel R. Kuritzkes, Elizabeth D. Anton, Fouchier, Fouchier, Furtado, Henry Sunpath, Hosseinipour, Hunt, Irlbeck, Jacqueline D. Reeves, Johnston, Kantor, Keshni Hiramen, Kuiken, Loemba, Low, Marconi, Nagavelli Padayachi, Ndungu, Novitsky, Reeves, Richard Murphy, Rizzuto, Scarlatti, Singh, Tamura, Taryn N. Green, Taylor, Thumbi Ndung'u, Tobin, Trinh, Tscherning, Wallis, Westby, Whitcomb, Wu, Yolanda Lie   +48 more
core   +2 more sources

Interventions for neurocognitive dysfunction [PDF]

, 2017
Purpose of review: To evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last three years. Recent findings: Optimal anti-retroviral therapy (ART) poses
Brew, B, Ellero, J, Lubomski, M
core   +2 more sources

Survival rate of HIV-infected children after initiation of the antiretroviral therapy and its predictors in Ethiopia: A facility-based retrospective cohort

SAGE Open Medicine, 2019
Objective: To determine the survival rate and predictors of HIV-infected children on antiretroviral therapy at two selected facilities in North Ethiopia.
Getachew Arage, Mekonnen Assefa, Teshager Worku, Agumasie Semahegn   +3 more
doaj   +1 more source

Factors of Loss to Follow-up Antiretroviral Therapy in Islanded Area

Unnes Journal of Public Health, 2018
Loss to follow-up of antiretroviral therapy is when PLWHA (People Living with HIV/AIDS) do not come for antiretroviral therapy for more than 3 months. This study aimed to determine the factors of loss to follow-up antiretroviral therapy for PLWHA at Prof.
Thomas Laga Boro, Rafael Paun, Marthen R Pellokila   +2 more
doaj   +1 more source

Comparison of treatment outcomes of new smear-positive pulmonary tuberculosis patients by HIV and antiretroviral status in a TB/HIV clinic, Malawi. [PDF]

PLoS ONE, 2013
Smear-positive pulmonary TB is the most infectious form of TB. Previous studies on the effect of HIV and antiretroviral therapy on TB treatment outcomes among these highly infectious patients demonstrated conflicting results, reducing understanding of ...
Hannock Tweya, Caryl Feldacker, Sam Phiri, Anne Ben-Smith, Lukas Fenner, Andreas Jahn, Mike Kalulu, Ralf Weigel, Chancy Kamba, Rabecca Banda, Matthias Egger, Olivia Keiser   +11 more
doaj   +1 more source