Results 41 to 50 of about 259,590 (298)

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Poor adherence to highly active antiretroviral therapy and associated factors among people living with HIV in Eastern Ethiopia

SAGE Open Medicine, 2022
Objective: Sustained adherence to highly active antiretroviral therapy is necessary to suppress viral replication and improve immunological and clinical outcomes.
Degu Tegegne, Galana Mamo, Belay Negash, Sisay Habte, Tesfaye Gobena, Shiferaw Letta   +5 more
doaj   +1 more source

Antiretroviral stewardship in a tertiary academic hospital: The need for a clinical pharmacist

Health SA Gesondheid: Journal of Interdisciplinary Health Sciences, 2023
Background: South Africa has the highest prevalence of people living with HIV globally. Although antiretroviral therapy provides solutions, evidence of antiretroviral resistance emerged, requiring the application of antiretroviral-stewardship programmes ...
Elmien Bronkhorst, Sonja Hattingh, Madan Poka   +2 more
doaj   +1 more source

Incidence rate of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity during the first year of treatment stratified by age

Brazilian Journal of Infectious Diseases, 2014
Toxicity is the most frequently reported reason for modifying or discontinuing the first combined antiretroviral therapy regimens, and it can cause significant morbidity, poor quality of life and also can be an important barrier to adherence, ultimately ...
Thiago Silva Torres, Sandra Wagner Cardoso, Luciane S. Velasque, Valdilea G. Veloso, Beatriz Grinsztejn   +4 more
doaj   +1 more source

Factors Affecting Adherence to Pediatrics Antiretroviral Therapy in Mekelle Hospital, Tigray Ethiopia [PDF]

, 2015
The most important factor in the success of HIV treatment is adherence to antiretroviral therapy (ART).The challenge to adherence to ART is particularly serious in Sub-Saharan Africa as the high rates of HIV/AIDS lead to greater numbers of affected ...
G/Amlak, T. (Tesfay), Gultie, T. (Teklemariam), Sebsibie, G. (Girum)   +2 more
core  

Sociodemographic and health systems determinants of antiretroviral therapy adherence among human immunodeficiency virus-positive patients in the Volta Region of Ghana: A multi-centre study

SAGE Open Medicine
Objectives: Optimal adherence to antiretroviral therapy is required for viral load suppression. This study investigated the sociodemographic (age, sex, marital status, level of education, monthly income, settlement type, distance to the antiretroviral ...
Elvis Enowbeyang Tarkang, Emmanuel Manu, Fortress Yayra Aku, Judith Anaman-Torgbor, Nelisiwe Khuzwayo   +4 more
doaj   +1 more source

Adherence to HIV antiretroviral therapy

South African Family Practice, 2006
Near perfect adherence to ART is required to prevent treatment failure in the individual and to prevent the spread of drug-resistant viruses. Factors that influence adherence to ART can be divided into factors related to the treatment regimen; social and
A. Heyer, G.A. Ogunbanjo
doaj   +1 more source

Short and long term retention in antiretroviral care in health facilities in rural Malawi and Zimbabwe. [PDF]

, 2012
Despite the successful scale-up of ART services over the past years, long term retention in ART care remains a major challenge, especially in high HIV prevalence and resource-limited settings.
A Boulle, A Kagee, AD Harries, AD Harries, AD Harries, AK Chan, AL Gifford, AP Hardon, D Ekouevi, D Swendeman, DW Krebs, DW Lowrance, E Losina, E Wouters, EH Geng, F Cellettti, F Shumbusho, Freya Rasschaert, GP Bisson, H Bussmann, H Tweya, JK Yu, JM Tassie, JS Stringer, L Ferradini, L Myer, LG Bekker, Lut Lynen, M Callaghan, M Egger, M Massaquoi, M McGuire, M Posse, Marcel Manzi, MP Fox, MW Brinkhof, Olivier Koole, P Braitstein, R Cohen, R Elema, R Zachariah, R Zachariah, Rony Zachariah, RP Dalal, RT Lester, RT Lester, S Rosen, S Rosen, S Thai, SD Lawn, SD Lawn, T Decroo, T Decroo, United Nations General Assembly, W Van Damme, W Van Damme, Wim Van Damme, Y Assefa   +57 more
core   +4 more sources

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source