Results 51 to 60 of about 2,497,556 (305)

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Adherence to HIV antiretroviral therapy

South African Family Practice, 2006
Near perfect adherence to ART is required to prevent treatment failure in the individual and to prevent the spread of drug-resistant viruses. Factors that influence adherence to ART can be divided into factors related to the treatment regimen; social and
A. Heyer, G.A. Ogunbanjo
doaj   +1 more source

Poor adherence to highly active antiretroviral therapy and associated factors among people living with HIV in Eastern Ethiopia

SAGE Open Medicine, 2022
Objective: Sustained adherence to highly active antiretroviral therapy is necessary to suppress viral replication and improve immunological and clinical outcomes.
Degu Tegegne, Galana Mamo, Belay Negash, Sisay Habte, Tesfaye Gobena, Shiferaw Letta   +5 more
doaj   +1 more source

Mother-to-child transmission of HIV infection in the era of highly active antiretroviral therapy [PDF]

, 2005
Background. Very low rates of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) are achievable with use of highly active antiretroviral therapy (HAART).
Canet, Y, SCHERPBIER H, FORTUNY C, Masuelli, G, Bates, I, A. Ehrnst, BUFFOLANO W, Barlow, P, Caro, MC, SUY A, J. Ma Pena, D. Perez-Tamarit, F. Hawkins, A. Suy, MARTINELLI P, SUAREZ G, Bohlin, AB, EHRNST A, DE MARIA A, Sansone, M, A. De Maria, LIDMAN K, Penn, Z, N. H. Valerius, HAINAUT M, KREYENBROEK M, R. Carreras, R. Tiseo, RABUSIN M, JIMENEZ J, DE JOSE I, Y. Canet, E. G. H. Lyall, Alberico, S, VALERIUS NH, Bernardon, M, Pena, JM, Ferrazi, E, Otero, MC, LOPEZ VILCHEZ MA, E. Ferrazzi, CARRERAS R, I. Bates, Taylor, GP, BOER K, P. Martinelli, M. Rabusin, Mok, J, LEVY J, Bassetti, D, A. Ferrazin, AGANGI A, Ruga, E, de Jose, I, BARLOW P, A. Mur, I. Grosch-Worner, Ferrazin, A, Garcia-Rodriguez, MC, Naver, L, FERRAZI E, ALBERICO S, M. Hainaut, M. Casellas Caro, MOK J, ASENSI BOTET F, Jimenez, J, A. Horban, Fortuny, C, G. P. Taylor, M. Kreyenbroek, GARCIA JG, HAWKINS F, A. De Rossi, COLL O, GOTTA C, Levy, J, Lindgren, S, PAYA A, Ehrnst, A, TAYLOR GP, Asensi-Botet, F, SANSONE M, M. Vinolas, Vinolas, M, Tiseo, R, J. Gonzalez Garcia, M. Bernardon, GOETGHEBUER T, NAVER L, Scherpbier, H, SAVASI V, et al, LOPEZ JRA, F. Asensi-Botet, C. Tibaldi, TIBALDI C, Coll, O, Garcia, JG, Marczynska, M, A. B. Bohlin, I. de Jose, TISEO R, PENN Z, De Rossi, A, Hainaut, M, Gotta, C, PEREZ TAMARIT DP, J. R. Arribas Lopez, RUGA, EZIA MARIA, C. Benedetto, T. Goetghebuer, MUR A, BOHLIN AB, Giaquinto, C, J. Mok, Goetghebuer, T, S. Marini, Carreras, R, OTERO MC, S. Lindgren, CANET Y, K. Boer, A. Viganò, Belfrage, E, GIAQUINTO, CARLO, H. Scherpbier, Valerius, NH, D. Bassetti, Anzen, B, LINDGREN S, Lopez-Vilchez, MA, BASSETTI D, V. Savasi, Kreyenbroek, M, Marini, S, Peltier, A, M. C. Garcia-Rodriguez, C. Ladron de Guevara, W. Buffolano, LYALL EGH, Mur, A, J. Levy, de Guevara, CL, DE ROSSI, ANITA, CARO MC, Z. Penn, ANZEN B, Hawkins, F, GROSCH WORNER I, VINOLAS M, C. Giaquinto, Grosch-Worner, I, Niemiec, T, J. Jimenez, B. Anzen, Suarez, G, Martinelli, P, Paya, A, O. Coll, J. M. Perez, G. Masuelli, Boer, K, Buffolano, W, M. A. Lopez-Vilchez, BELFRAGE E, Rovira, Perez-Tamarit, DP, Lidman, K, C. Gotta, E. Ruga, VIGANO A, M. Sansone, E. Belfrage, Tibaldi, C, DE GUEVARA CL, S. Alberico, BATES I, Perez, JM, A. Peltier, P. Barlow, A. Paya, PELTIER A, G. Suarez, FERRAZIN A, Lopez, JRA, Vigano, A, Agangi, A, PENA JM, K. Lidman, Horban, A, C. Fortuny, M. C. Otero, A. Agangi, De Maria, A, BERNARDON M, GARCIA RODRIGUEZ MC, T. Niemiec ̧ M. Marczynskam, Benedetto, C, Rabusin, M, Suy, A, Lyall, EGH, PEREZ JM, L. Naver, Savasi, V   +204 more
core   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Incidence rate of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity during the first year of treatment stratified by age

Brazilian Journal of Infectious Diseases, 2014
Toxicity is the most frequently reported reason for modifying or discontinuing the first combined antiretroviral therapy regimens, and it can cause significant morbidity, poor quality of life and also can be an important barrier to adherence, ultimately ...
Thiago Silva Torres, Sandra Wagner Cardoso, Luciane S. Velasque, Valdilea G. Veloso, Beatriz Grinsztejn   +4 more
doaj   +1 more source

Six-Month Mortality among HIV-Infected Adults Presenting for Antiretroviral Therapy with Unexplained Weight Loss, Chronic Fever or Chronic Diarrhea in Malawi. [PDF]

, 2012
In sub-Saharan Africa, early mortality is high following initiation of antiretroviral therapy (ART). We investigated 6-month outcomes and factors associated with mortality in HIV-infected adults being assessed for ART initiation and presenting with ...
Anderson, Suzanne T, Corbett Elizabeth, Ann Åkesson, Ramsay Andrew, Corbett, Elizabeth, Harries, Anthony D, Zachariah Rony, Adrienne K Chan, Elizabeth Corbett, Alexandra L C Martiniuk, Heyderman Robert S., Robert S Heyderman, Martiniuk, Alexandra L C, Chan, Adrienne K, Richard A Bedell, Chan Adrienne K., Zachariah, Rony, Martiniuk, Alexandra LC, Akesson, Ann, Andrew Ramsay, Anthony D Harries, Anderson Suzanne T., Ramsay, Andrew, Monique van Lettow, Åkesson Ann, Bedell, Richard A, van Lettow Monique, Suzanne T Anderson, Bedell Richard A., Martiniuk Alexandra L. C., Harries Anthony D., van Lettow, Monique, Heyderman, Robert S, Rony Zachariah   +33 more
core   +1 more source

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source

Sociodemographic and health systems determinants of antiretroviral therapy adherence among human immunodeficiency virus-positive patients in the Volta Region of Ghana: A multi-centre study

SAGE Open Medicine
Objectives: Optimal adherence to antiretroviral therapy is required for viral load suppression. This study investigated the sociodemographic (age, sex, marital status, level of education, monthly income, settlement type, distance to the antiretroviral ...
Elvis Enowbeyang Tarkang, Emmanuel Manu, Fortress Yayra Aku, Judith Anaman-Torgbor, Nelisiwe Khuzwayo   +4 more
doaj   +1 more source

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, EarlyView.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source