Results 41 to 50 of about 286,453 (328)

Incidence rate of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity during the first year of treatment stratified by age

Brazilian Journal of Infectious Diseases, 2014
Toxicity is the most frequently reported reason for modifying or discontinuing the first combined antiretroviral therapy regimens, and it can cause significant morbidity, poor quality of life and also can be an important barrier to adherence, ultimately ...
Thiago Silva Torres, Sandra Wagner Cardoso, Luciane S. Velasque, Valdilea G. Veloso, Beatriz Grinsztejn   +4 more
doaj   +1 more source

Antiretroviral stewardship in a tertiary academic hospital: The need for a clinical pharmacist

Health SA Gesondheid: Journal of Interdisciplinary Health Sciences, 2023
Background: South Africa has the highest prevalence of people living with HIV globally. Although antiretroviral therapy provides solutions, evidence of antiretroviral resistance emerged, requiring the application of antiretroviral-stewardship programmes ...
Elmien Bronkhorst, Sonja Hattingh, Madan Poka   +2 more
doaj   +1 more source

Demographic characteristics and opportunistic diseases associated with attrition during preparation for antiretroviral therapy in primary health centres in Kibera, Kenya. [PDF]

, 2011
Using routine data from HIV-positive adult patients eligible for antiretroviral therapy (ART), we report on routinely collected demographic characteristics and opportunistic diseases associated with pre-ART attrition (deaths and loss to follow-up). Among
Amuron, Anglaret, Boehme, Braitstein, Etard, Fox, Gilks, Gilks, Grant, Ingle, Ingle, Janoof, Jones, Larson, Lawn, Lawn, Lucas, Peters, Scott, Van Griensven, Zachariah   +20 more
core   +2 more sources

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Sociodemographic and health systems determinants of antiretroviral therapy adherence among human immunodeficiency virus-positive patients in the Volta Region of Ghana: A multi-centre study

SAGE Open Medicine
Objectives: Optimal adherence to antiretroviral therapy is required for viral load suppression. This study investigated the sociodemographic (age, sex, marital status, level of education, monthly income, settlement type, distance to the antiretroviral ...
Elvis Enowbeyang Tarkang, Emmanuel Manu, Fortress Yayra Aku, Judith Anaman-Torgbor, Nelisiwe Khuzwayo   +4 more
doaj   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Pharmacovigilance of Antiretroviral Drugs at B.P. Koirala Institute of Health sciences

Journal of Nepal Health Research Council, 2021
Background: Antiretroviral drugs are lifeline for patients living with HIV. Adverse drug reactions can compromise the compliance to antiretroviral therapy.
Deependra Prasad Sarraf, Gajendra Prasad Rauniar, Roshan Chhetri, Shyam Prasad Kafle, Suchana Marahatta, Basudha Khanal, Sanjib Kumar Sharma, Vivek Kattel   +7 more
doaj   +1 more source

Emerging priorities for HIV service delivery [PDF]

, 2020
Nathan Ford and co-authors discuss global priorities in the provision of HIV prevention and treatment ...
et al.,, Ford, Nathan, Geng, Elvin
core   +1 more source

The art of HIV elimination: past and present science [PDF]

, 2015
Introduction: Remarkable strides have been made in controlling the HIV epidemic, although not enough to achieve epidemic control. More recently, interest in biomedical HIV control approaches has increased, but substantial challenges with the HIV cascade ...
de Oliveira, T., Fisher, M., Lwuji, C.C., McGrath, N., Newell, M.-L., Newport, M., Pillay, D., Porter, K.   +7 more
core   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source