Results 121 to 130 of about 8,514 (288)

Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis: A shared phenotype across brain‐expressed sodium channelopathies

Epilepsia, EarlyView.
Abstract Objective Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis (NDEEMA) represents the most severe end of the gain‐of‐function (GOF) SCN1A disorder spectrum. Sporadic cases of congenital arthrogryposis have also been reported in individuals with SCN2A‐, SCN3A‐, and SCN8A‐related developmental and ...
Sopio Gverdtsiteli, Sebastian Ortiz, Tobias Brünger, Francesca Furia, Carmen Barba, Trine Bjørg‐Hammer, Ingo Borggraefe, Roberto Caraballo, Sebahattin Cirak, Alberto Espeche, Walid Fazeli, Renzo Guerrini, Matias Juanes, Karin Kassahn, Maria Kinali, Johannes Krämer, Judith Kröll, Maria Concepción Miranda Herrero, Renske Oegema, Katrin Ounap, Oscar Peñuela, Konrad Platzer, Asuri Narayan Prasad, Aurora Pujol, Karit Reinson, Alfonso Represa, Eugenia Roza, Gabriela Reyes Valenzuela, Agustí Rodríguez‐Palmero, Suzanne Sallevelt, Maria Iciar Sanchez‐Albiusa, Ingrid E. Scheffer, Cory Smid, Carl E. Stafstrom, Eva‐Lena Stattin, Jen R. Suarez, Steffen Syrbe, Kette D. Valente, Matias Wagner, Saskia Wortmann, Elena Gardella, Dennis Lal, Andreas Brunklaus, Rikke S. Møller   +43 more
wiley   +1 more source

Antiseizure medications in CDKL5 encephalopathy– systematic review

Seizure: European Journal of Epilepsy
Background Cyclin-dependent kinase-like 5 deficiency disorder (CDD) is a disease belonging to the group of developmental and epileptic encephalopathies (DEE), characterized by drug-resistant epilepsy, delayed psychomotor development, premature mortality, and movement disorders.
Adrianna Kalinowska-Doman, Adam Strzelczyk, Justyna Paprocka   +2 more
openaire   +3 more sources

Impact of antiseizure medication taper on electroencephalographic dynamics in focal epilepsy : A stereoelectroencephalographic study

Objective Tapering of the antiseizure medication dosage in the epilepsy monitoring unit can provoke seizures, but its effects on seizure dynamics remain poorly characterized.
Conrad, Erin C., Wei, Xiaoyan, Hannan, Sana, Ho, Alyssa, Frauscher, Birgit, Thomas, John, Shao, Xiaoqiu, Moye, Matthew, Ren, Guoping, Schiller, Katharina, Avigdor, Tamir, Wang, Qun, Radtke, Rodney, Jaber, Kassem, Hall, Jeffery, Gotman, Jean, Ghosn, Nina J., Southwell, Derek, Ye, Hongyi   +18 more
core  

Cenobamate, a New Promising Antiseizure Medication: Experimental and Clinical Aspects

About 40–50% of patients with drug-resistant epilepsy do not properly respond to pharmacological therapy with antiseizure medications (ASMs). Recently approved by the US Food and Drug Administration and European Medicines Agency as an add-on drug ...
Barbara Błaszczyk, Stanisław J. Czuczwar, Barbara Miziak   +2 more
core   +1 more source

Systematic statistical analysis of change in SEIzure interVAL with diazepam nasal spray supports this novel clinical endpoint for immediate‐use seizure medication

Epilepsia, EarlyView.
Abstract Objective Appropriate endpoints for daily antiseizure medications may differ from those for intermittent, immediate‐use seizure medications (ISMs). The observed interval between seizure clusters over time (SEIzure interVAL [SEIVAL]) has been proposed as a novel effectiveness endpoint for ISMs.
Wesley T. Kerr, Katherine N. McFarlane, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz   +4 more
wiley   +1 more source

Clinical burden and treatment patterns associated with Dravet or Lennox-Gastaut syndromes: A retrospective study using natural language processing of narrative unstructured electronic health records

Heliyon
Introduction: This study aimed to investigate the clinical and humanistic burden in two developmental and epileptic encephalopathies, Dravet syndrome and Lennox-Gastaut syndrome, and describe challenges related to treatment with antiseizure medications ...
Mei Lu, Dave Iwanyckyj, Sally W. Wade, Pablo Racana, Fernando Otalora, Satish Rao   +5 more
doaj   +1 more source

Antiseizure medications and their differing effects on cardiovascular risk

Epilepsy & Behavior Reports
This review discusses the differing effects of enzyme-inducing and non-inducing antiseizure medications on cardiovascular risk and their implications for the management strategies of epilepsy patients. Traditional risk markers, including low density lipoprotein, high density lipoprotein and triglycerides, can be altered by both enzyme induction and ...
Aleena Abbasi, Bassil Abbasi, Scott Mintzer, Carla LoPinto-Khoury   +3 more
openaire   +3 more sources

Artificial intelligence for adaptive neuromodulation in drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects nearly one third of people with epilepsy and is associated with substantial cognitive, psychiatric, and mortality burdens. For patients who are not candidates for resection or laser interstitial thermal therapy, neuromodulation therapies such as vagus nerve stimulation, deep brain stimulation, and ...
Amir Hossein Daraie, Arianna Damiani, Mahsa Khoshkhou, Luis A. Sanchez, Rachel J. Smith, Shruti H. Agashe, Jorge A. Gonzalez‐Martinez, Jennifer Hopp, Adam S. Charles, Sridevi V. Sarma, Joon‐Yi Kang   +10 more
wiley   +1 more source

Teratogenicity and Antiseizure Medications

Epilepsy Currents, 2020
openaire   +2 more sources

Pediatric sensorimotor cortical responsiveness to intracerebral stimulation during stereoelectroencephalographic monitoring: Age effects and area specificity

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to determine how age influences clinical responsiveness to intracerebral electrical stimulation (IES) in children across primary and secondary sensorimotor cortices and to assess age effects on response complexity and area‐specific responsiveness.
Giulia Nobile, Laura Tassi, Marta Ponzano, Piergiorgio d'Orio, Alessandro Consales, Luca Bosisio, Stefano Francione, Gabriele Arnulfo, Maria Pia Sormani, Lino Nobili, Roberto Mai   +10 more
wiley   +1 more source