Results 41 to 50 of about 353,788 (280)

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source

Medication adherence and treatment gap in Sudanese children with epilepsy during armed conflict: a one-unit retrospective clinical audit

BMC Pediatrics
Background Armed conflict disrupts health systems and disproportionately affects children with chronic neurological conditions such as epilepsy. Evidence on medication adherence during conflicts is limited.
Haydar El Hadi Babikir Saad, Salma Hassan Mohammed Eltahir   +1 more
doaj   +1 more source

Innovative epilepsy management: a combined figure of EEG categorization and medication mechanisms

Frontiers in Neurology
IntroductionEpilepsy management requires precision in diagnosis and treatment, particularly when selecting antiseizure medications based on specific epilepsy syndromes.
Mohamed Taha, Douglas R. Nordli, Carol Park, Douglas R. Nordli   +3 more
doaj   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Data_Sheet_1_Excessively increased thalamocortical connectivity and poor initial antiseizure medication response in epilepsy patients.docx

, 2023
ObjectivesThe network mechanism underlying the initial response to antiseizure medication in epilepsy has not been revealed yet. Given the central role of the thalamus in the brain network, we conducted a case-control study to investigate the association
Jiyuan Zhong, Haijiao Wang, Ge Tan (3326088), Yangmei Chen (702818), Ge Tan, Yangmei Chen, Jiyuan Zhong (16381545), Haijiao Wang (170477)   +7 more
core   +1 more source

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source

Anti-seizure medication discontinuation in pediatric epilepsy patients in pediatric neurology practice: A single center experience

Medicine Science
The objective of this study was to investigate the relapse rate and associated factors following the discontinuation of antiseizure medication in pediatric patients diagnosed with epilepsy.
Hilal Aydin, Ozlem Kemer Aycan, Oguzhan Korkut, Betul Tosun   +3 more
doaj   +1 more source

Medication administration errors for older people in long-term residential care [PDF]

, 2011
Background Older people in long-term residential care are at increased risk of medication errors. The purpose of this study was to evaluate a computerised barcode medication management system designed to improve drug administrations in residential and ...
Nelson Sara, Szczepura, Ala, Wild, Deidre, Sara Nelson, Nelson, S. (Sara), Nelson, Sara, Wilde, P, Nelson, Sarah, Szczepura Ala, Ala Szczepura, Deidre Wild, Wild Deidre, Szczepura, Ala; id_orcid   +12 more
core   +2 more sources

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

Lamotrigine as an antiseizure medication in pregnancy

Seizure: European Journal of Epilepsy
To try to ascertain in APR data why lamotrigine was the preferred ASM in treating women with epilepsy, METHOD: Statistical analysis of foetal malformation and seizure free pregnancy occurrence rates associated with lamotrigine use in monotherapy and polytherapy RESULTS: Among commonly used ASMs, lamotrigine (4.6%) and levetiracetam (4.5%) in ...
Frank J.E. Vajda, Terence J. O’Brien, Janet E. Graham, Alison E. Hitchcock, Piero Perucca, Cecilie M. Lander, Mervyn J. Eadie   +6 more
openaire   +4 more sources