Mechanistic insight into the anti-inflammatory and lung-protective effects of <i>Agrimonia pilosa</i> extract via NF-κB/MAPK inhibition in ovalbumin- and lipopolysaccharide-induced respiratory inflammation models. [PDF]
Pharm BiolLee YG +7 more
europepmc +1 more source
RNA therapeutics: beyond RNA interference and antisense oligonucleotides
Nature reviews. Drug discovery, 2012 R. Kole, A. Krainer, S. Altman
semanticscholar +1 more source
Evaluation of gene editing in CHO cells using the Cas‐CLOVER system
Biotechnology Progress, EarlyView.Abstract Recent advances in gene editing technologies have transformed the genetic engineering of Chinese hamster ovary (CHO) hosts, enabling the development of cell lines with improved stability and productivity. In this study, we employed the programmable nuclease (PN) Cas‐CLOVER to precisely target the Glutamine synthetase (GS) locus in CHO cells. A
Tiffany McLamarrah +13 more
wiley +1 more source
Targeting lncRNA DSCAM-AS1 for disease diagnosis and therapy. [PDF]
Noncoding RNA ResZhou L, Jin Y, Li Z, Dong H, Jin Y.
europepmc +1 more source
Mini‐Hairpin DNA: Extraordinarily Stable Structure and Its Applications
Chemistry – A European Journal, EarlyView.Mini‐hairpin DNA fragments containing GCGAAGC and GCGAAAGC form exceptionally stable hairpin‐like structures, with only two G−C pairs and one sheared G−A pair, remaining undenatured in 7 M urea and resisting nuclease digestion. These mini‐hairpin sequences frequently appear in replication and transcription origins, influence DNA sequencing fidelity ...
Michiko Kimoto, Ichiro Hirao
wiley +1 more source
Integrative multi-omics analysis widens annotation and functional insights into long non-coding RNAs of Arabidopsis thaliana. [PDF]
Biol DirectVivek AT +4 more
europepmc +1 more source
Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents
Chemistry – A European Journal, EarlyView.This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley +1 more source
Rare Variants in Antisense Long Noncoding RNA-Protein-Coding Gene Overlap Regions Contribute to Obsessive-Compulsive Disorder. [PDF]
Biol Psychiatry Glob Open SciJung S, Caballero M, Smout S, Mahjani B.
europepmc +1 more source
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia
Proceedings of the National Academy of Sciences of the United States of America, 2013 T. Zu +13 more
semanticscholar +1 more source
RORγt‐APCs: The New Masters of Oral Tolerance
Barrier Immunity, EarlyView.ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley +1 more source