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Functional role of THRAP3 in modulating thyroid hormone-mediated gene networks in C2C12 myotubes. [PDF]
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Current Opinion in Oncology, 1996
The sequence specificity of the antisense technique makes it an attractive basis for novel molecular therapeutics. Inhibition of gene expression by antisense in cell culture models has provided a strong rationale for identification and validation of disease targets.
R, Narayanan, S, Akhtar
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The sequence specificity of the antisense technique makes it an attractive basis for novel molecular therapeutics. Inhibition of gene expression by antisense in cell culture models has provided a strong rationale for identification and validation of disease targets.
R, Narayanan, S, Akhtar
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Nephron Experimental Nephrology, 1998
Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense ...
N, Kashihara, Y, Maeshima, H, Makino
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Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense ...
N, Kashihara, Y, Maeshima, H, Makino
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Antisense oligodeoxynucleotides
Current Opinion in Oncology, 1994Oligodeoxynucleotides have been proposed as both in vitro and in vivo inhibitors of gene expression because of the specificity of Watson-Crick base pair hybridization. Phosphodiester oligodeoxynucleotides (normal DNA) cannot be used as drugs because they are nuclease sensitive.
C A, Stein, R, Narayanan
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Antisense antibacterial compounds
Translational Research, 2020Extensive antibiotic use combined with poor historical drug stewardship practices have created a medical crisis in which once treatable bacterial infections are now increasingly unmanageable. To combat this, new antibiotics will need to be developed and safeguarded.
Reed, Pifer, David E, Greenberg
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Current Opinion in Chemical Biology, 1998
The field of antisense therapeutics has attracted great interest during the past decade. A large body of literature has recently appeared in which the antisense mechanism is claimed to be involved and a number of human clinical trials are underway.
S, Agrawal, Q, Zhao
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The field of antisense therapeutics has attracted great interest during the past decade. A large body of literature has recently appeared in which the antisense mechanism is claimed to be involved and a number of human clinical trials are underway.
S, Agrawal, Q, Zhao
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Antisense Research and Development, 1991
The antiviral use of antisense oligonucleotides is described with particular reference to our own work on the inhibition of HIV-1. Subjects include the design, metabolism, and modification of these agents and the possible future use of ribozymes.
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The antiviral use of antisense oligonucleotides is described with particular reference to our own work on the inhibition of HIV-1. Subjects include the design, metabolism, and modification of these agents and the possible future use of ribozymes.
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Current Opinion in Biotechnology, 1991
During the past 12 months, significant advances have been reported in the medicinal chemistry, and the pharmacodynamic and pharmacokinetic characterization of oligonucleotides. Advances in medicinal chemistry suggest that the scope for additional modifications as a means of developing therapeutic agents is substantial.
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During the past 12 months, significant advances have been reported in the medicinal chemistry, and the pharmacodynamic and pharmacokinetic characterization of oligonucleotides. Advances in medicinal chemistry suggest that the scope for additional modifications as a means of developing therapeutic agents is substantial.
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