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Antisense oligonucleotides in cancer
Current Opinion in Oncology, 2014Over the past several dozen years, regardless of the substantial effort directed toward developing rational oligonucleotide strategies to silence gene expression, antisense oligonucleotide-based cancer therapy has not been successful. This review focuses on the most likely reasons for this lack of success, and on the barriers that still need to be ...
Daniela, Castanotto, Cy A, Stein
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Toxicology of antisense therapeutics
Toxicology and Applied Pharmacology, 2004Targeting unique mRNA molecules using antisense approaches, based on sequence specificity of double-stranded nucleic acid interactions should, in theory, allow for design of drugs with high specificity for intended targets. Antisense-induced degradation or inhibition of translation of a target mRNA is potentially capable of inhibiting the expression of
L.H. Jason, Tracey +2 more
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Antisense agents in pharmacology
Biochemical Pharmacology, 1990This commentary is designed to evaluate the applications and potential applications of antisense agents for the pharmacologist. The issues of mechanism of the biologic response mediated by antisense oligodeoxyribonucleotides (ODNs*) and evaluation of an antisense response are discussed.
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Purification of antisense oligonucleotides
2000Chromatography is an effective tool for obtaining high-purity synthetic oligonucleotides for a variety of end uses, including antisense drug therapy. Reversed-phase and anion-exchange chromatographies are widely used techniques for this application. While selectivity of these techniques can be modified by methods such as ion-pair RP-HPLC or affinity ...
R R, Deshmukh, D L, Cole, Y S, Sanghvi
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Cancer and Metastasis Reviews, 1998
During the last ten years, antisense technology has experienced growing pains not unlike those of adolescence. In 1992, antisense was trumpeted as one of the top 10 emerging research areas. However, 3 years later, researchers were confronted with significant problems associated with antisense oligonucleotides ranging from sequence-dependent, non ...
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During the last ten years, antisense technology has experienced growing pains not unlike those of adolescence. In 1992, antisense was trumpeted as one of the top 10 emerging research areas. However, 3 years later, researchers were confronted with significant problems associated with antisense oligonucleotides ranging from sequence-dependent, non ...
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Molecular Cell Biology Research Communications, 2000
M, Sohail, E M, Southern
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M, Sohail, E M, Southern
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History of Antisense Oligonucleotides
2003Biological science is a rapidly flowing experimental stream, at times encountering a dam that impedes further progress. At such a pomt, a single crack may induce a major breakthrough Discovery of the double helical structure of DNA in 1953 (1) caused such an event, with flooding of new information into the area now known as molecular biology.
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Antisense technology: an overview and prospectus
Nature Reviews Drug Discovery, 2021Stanley T Crooke +2 more
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