Results 261 to 270 of about 378,124 (311)
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Trends in Biochemical Sciences, 2004
In recent years, natural antisense transcripts (NATs) have been implicated in many aspects of eukaryotic gene expression including genomic imprinting, RNA interference, translational regulation, alternative splicing, X-inactivation and RNA editing. Moreover, there is growing evidence to suggest that antisense transcription might have a key role in a ...
Lavorgna G +5 more
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In recent years, natural antisense transcripts (NATs) have been implicated in many aspects of eukaryotic gene expression including genomic imprinting, RNA interference, translational regulation, alternative splicing, X-inactivation and RNA editing. Moreover, there is growing evidence to suggest that antisense transcription might have a key role in a ...
Lavorgna G +5 more
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Current Opinion in Biotechnology, 1991
During the past 12 months, significant advances have been reported in the medicinal chemistry, and the pharmacodynamic and pharmacokinetic characterization of oligonucleotides. Advances in medicinal chemistry suggest that the scope for additional modifications as a means of developing therapeutic agents is substantial.
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During the past 12 months, significant advances have been reported in the medicinal chemistry, and the pharmacodynamic and pharmacokinetic characterization of oligonucleotides. Advances in medicinal chemistry suggest that the scope for additional modifications as a means of developing therapeutic agents is substantial.
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Current Opinion in Chemical Biology, 1998
The field of antisense therapeutics has attracted great interest during the past decade. A large body of literature has recently appeared in which the antisense mechanism is claimed to be involved and a number of human clinical trials are underway.
S, Agrawal, Q, Zhao
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The field of antisense therapeutics has attracted great interest during the past decade. A large body of literature has recently appeared in which the antisense mechanism is claimed to be involved and a number of human clinical trials are underway.
S, Agrawal, Q, Zhao
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Current Molecular Medicine, 2004
Antisense technology exploits oligonucleotide analogs to bind to target RNAs via Watson-Crick by hybridization. Once bound, the antisense agent either disables or induces the degradation of the target RNA. Antisense agents may also be used to alter splicing. Developing antisense technology involves the creation of a new pharmacology. The receptors, pre-
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Antisense technology exploits oligonucleotide analogs to bind to target RNAs via Watson-Crick by hybridization. Once bound, the antisense agent either disables or induces the degradation of the target RNA. Antisense agents may also be used to alter splicing. Developing antisense technology involves the creation of a new pharmacology. The receptors, pre-
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Nature Biotechnology, 2002
It took a leap of faith for researchers to believe that antisense technology might lead to novel medicines, but that commitment could soon pay off.
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It took a leap of faith for researchers to believe that antisense technology might lead to novel medicines, but that commitment could soon pay off.
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Antisense Research and Development, 1991
The antiviral use of antisense oligonucleotides is described with particular reference to our own work on the inhibition of HIV-1. Subjects include the design, metabolism, and modification of these agents and the possible future use of ribozymes.
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The antiviral use of antisense oligonucleotides is described with particular reference to our own work on the inhibition of HIV-1. Subjects include the design, metabolism, and modification of these agents and the possible future use of ribozymes.
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European Journal of Cancer, 2005
The specific and rational targeting of key genes, identified to be vital to driving cancer growth, has recently led to the successful development of several small molecule and antibody therapeutics. However, despite considerable efforts, antisense oligonucleotides (ASO) have yet to prove their worth as targeted therapies.
Laura, Vidal +3 more
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The specific and rational targeting of key genes, identified to be vital to driving cancer growth, has recently led to the successful development of several small molecule and antibody therapeutics. However, despite considerable efforts, antisense oligonucleotides (ASO) have yet to prove their worth as targeted therapies.
Laura, Vidal +3 more
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Antisense in Abundance: The Ribosome as a Vehicle for Antisense RNA
1998Insertions at some sites within rRNA variable regions can be tolerated without affecting rRNA function. Antisense RNAs inserted at such sites in the T. thermophila rRNA can eliminate phenotypically or immunologically detectable gene expression of three genes tested. This unusually effective antisense activity is probably due to the abundance, stability
R, Sweeney, Q, Fan, M C, Yao
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Annals of the New York Academy of Sciences, 1992
The use of antisense technology in animals has great potential for studying individual genes and for generating animal models of human disorders. Further control can be obtained by the use of inducible promoters to regulate the expression of antisense constructs, so that the timing and degree of antisense inhibition can be manipulated.
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The use of antisense technology in animals has great potential for studying individual genes and for generating animal models of human disorders. Further control can be obtained by the use of inducible promoters to regulate the expression of antisense constructs, so that the timing and degree of antisense inhibition can be manipulated.
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Perspectives in antisense therapeutics
Pharmacology & Therapeutics, 1997Modulation of gene expression using oligonucleotides (oligos) is currently an area of intense activity, both from therapeutic, as well as research perspectives. To develop oligos as therapeutic agents, in addition to demonstrable biological activity, in vivo metabolic stability, tissue disposition and pharmacokinetics are important considerations ...
S, Agrawal, R P, Iyer
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