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Weaknesses out of strength: PNA against the penicillin-binding proteins. [PDF]
Mol Ther Nucleic AcidsWdowiak M.
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A fully automated novel solid-phase extraction method for siRNA drug extraction and quantitation across multiple tissues using LC-MS. [PDF]
BioanalysisKarlsborn T +3 more
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The delivery of antisense therapeutics
Advanced Drug Delivery Reviews, 2000Antisense oligonucleotides, ribozymes and DNAzymes have emerged as novel, highly selective inhibitors or modulators of gene expression. Indeed, their use in the treatment of diseases arising from genetic abnormalities has become a real possibility over the past few years. The first antisense drug molecule is now available for clinical use in Europe and
Saghir Akhtar
exaly +3 more sources
Current Opinion in Oncology, 1996
The sequence specificity of the antisense technique makes it an attractive basis for novel molecular therapeutics. Inhibition of gene expression by antisense in cell culture models has provided a strong rationale for identification and validation of disease targets.
R, Narayanan, S, Akhtar
openaire +2 more sources
The sequence specificity of the antisense technique makes it an attractive basis for novel molecular therapeutics. Inhibition of gene expression by antisense in cell culture models has provided a strong rationale for identification and validation of disease targets.
R, Narayanan, S, Akhtar
openaire +2 more sources
Nephron Experimental Nephrology, 1998
Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense ...
N, Kashihara, Y, Maeshima, H, Makino
openaire +2 more sources
Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense ...
N, Kashihara, Y, Maeshima, H, Makino
openaire +2 more sources
Science, 2001
In his article “A faster way to shut down genes” (News of the Week, 25 May, p. [1469][1]), R. John Davenport describes a promising technique called RNA interference for selectively silencing genes in a range of organisms. But in comparing the new approach to antisense methods, he makes a false assertion: “Fifteen years ago, antisense methods for gene ...
R K, Koehn, J, Rossi, C A, Stein
openaire +2 more sources
In his article “A faster way to shut down genes” (News of the Week, 25 May, p. [1469][1]), R. John Davenport describes a promising technique called RNA interference for selectively silencing genes in a range of organisms. But in comparing the new approach to antisense methods, he makes a false assertion: “Fifteen years ago, antisense methods for gene ...
R K, Koehn, J, Rossi, C A, Stein
openaire +2 more sources
Antisense oligodeoxynucleotides
Current Opinion in Oncology, 1994Oligodeoxynucleotides have been proposed as both in vitro and in vivo inhibitors of gene expression because of the specificity of Watson-Crick base pair hybridization. Phosphodiester oligodeoxynucleotides (normal DNA) cannot be used as drugs because they are nuclease sensitive.
C A, Stein, R, Narayanan
openaire +2 more sources