Results 81 to 90 of about 443,792 (339)

A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression [PDF]

, 2015
Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are ...
AC Thénié, B Holmqvist, B Kuzin, B Moreno-Lopez, BL Sopher, C-H Cheng, D Dahary, DS Bredt, E Ciani, E Pavesi, GB Robb, J Chen, J Garthwaite, J-T Li, JB Kelley, JE Fish, JH Brann, K Matsui, KY Kwan, L Zhou, MA Faghihi, MA Packer, ME Evangelopoulos, ME Evangelopoulos, MHT Ling, N Peunova, P Ogilvie, RG Tremblay, S Hindley, S Korneev, SA Korneev, SA Korneev, SA Korneev, SA Korneev, SM Gibbs, SR Vincent, U Forstermann, V Calabrese, Y Zhang   +38 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Neuronal Expression of Neural Nitric Oxide Synthase (nNOS) Protein is Suppressed by an Antisense RNA Transcribed from an NOS Pseudogene [PDF]

, 1999
Here, we show that a nitric oxide synthase (NOS) pseudogene is expressed in the CNS of the snail Lymnaea stagnalis. The pseudo-NOS transcript includes a region of significant antisense homology to a previously reported neuronal NOS (nNOS)-encoding mRNA ...
Korneev, Sergei A, O'Shea, Michael, Park, Ji-Ho   +2 more
core   +2 more sources

Delivery is key: lessons learnt from developing splice‐switching antisense therapies

EMBO Molecular Medicine, 2017
The use of splice‐switching antisense therapy is highly promising, with a wealth of pre‐clinical data and numerous clinical trials ongoing. Nevertheless, its potential to treat a variety of disorders has yet to be realized. The main obstacle impeding the
C. Godfrey, L. Desviat, B. Smedsrød, F. Piétri‐Rouxel, M. Denti, P. Disterer, S. Lorain, G. Nogales-Gadea, V. Sardone, Rayan Anwar, S. El Andaloussi, Taavi Lehto, B. Khoo, Camilla Brolin, W. V. van Roon-Mom, A. Goyenvalle, Annemieke Aartsma-Rus, V. Arechavala-Gomeza   +17 more
semanticscholar   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Natural Antisense Transcripts [PDF]

RNA Biology, 2005
The sequencing of whole genomes and the subsequent annotation of cDNAs revealed that about 20% of human and mouse genes overlap resulting in potential pairs of sense and antisense transcripts. An increasing number of experimentally identified antisense transcripts concur with this predication.
openaire   +2 more sources

Sirt1 Antisense Long Noncoding RNA Promotes Cardiomyocyte Proliferation by Enhancing the Stability of Sirt1

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2018
Background Antisense long noncoding RNAs (lncRNAs) are single‐stranded RNAs that overlapped gene‐coding regions on the opposite DNA strand and play as critical regulators in cardiovascular diseases.
Bing Li, Yinlan Hu, Xinzhong Li, Guoqing Jin, Xiaoqiang Chen, Guojun Chen, Yanmei Chen, Senlin Huang, W. Liao, Y. Liao, Zhonghua Teng, J. Bin   +11 more
semanticscholar   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

The differential impact of HNRNPA1 isoforms on gene expression and their relevance to dsRNA-mediated innate immune response

Scientific Reports
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) is a highly abundant RNA binding protein alternatively spliced in two main isoforms named, hnRNP A1 and hnRNP A1B.
Jade-Emmanuelle Deshaies, Valérie Triassi, Andréanne Lacombe, Myriam Gagné, Karen Ling, Asmita Ghosh, Marjorie Labrecque, Frank Rigo, Paymaan Jafar-nejad, Martine Tétreault, Christine Vande Velde   +10 more
doaj   +1 more source

Interaction of α-Melanocortin and Its Pentapeptide Antisense LVKAT: Effects on Hepatoprotection in Male CBA Mice

Molecules, 2011
The genetic code defines nucleotide patterns that code for individual amino acids and their complementary, i.e., antisense, pairs. Peptides specified by the complementary mRNAs often bind to each other with a higher specificity and efficacy. Applications
Paško Konjevoda, Tin Weitner, Mario Gabričević, Petra Turčić, Karlo Houra, Nikola Štambuk   +5 more
doaj   +1 more source