Results 161 to 170 of about 45,567 (253)

MAFLD/MASLD: Past, Present, and Future

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD), also known as nonalcoholic fatty liver disease and metabolic dysfunction‐associated fatty liver disease, affects more than 30% of the global adult population and has become one of the leading causes of cirrhosis and hepatocellular carcinoma.
Vincent Wai‐Sun Wong
wiley   +1 more source

Antisense Oligonucleotides: Technological Advances, Clinical Progress, and Expanding Therapeutic Frontiers. [PDF]

Pharmaceutics
Xu L, Zhang H, Jiang B, Jiang Y, Lu H.
europepmc   +1 more source

ZmMS1 coordinates ROS homeostasis, lipid allocation, and male fertility for maize breeding applications

Journal of Integrative Plant Biology, EarlyView.
The redox‐sensitive transcriptional repressor ZmMS1 coordinates reactive oxygen species homeostasis and lipid allocation for pollen exine and anther cuticle formation. Loss or precocious expression of ZmMS1 causes male sterility. Constitutive overexpression induces dwarfism and semi‐sterility. These findings enable flexible maize male‐sterility systems
Quancan Hou, Xueli An, Zhenying Dong, Biao Ma, Suowei Wu, Ke Xie, Ziwen Li, Tingwei Yan, Yilin Jiang, Taotao Zhu, Bin Ma, Lina Zhao, Yan Long, Xiangyuan Wan   +13 more
wiley   +1 more source

Contact Unmodified Antisense DNA Biotechnology (CUADb)-Based Oligonucleotide Insecticides and RNA Biocontrols: Molecular Bases and Potential in Plant Protection. [PDF]

Curr Issues Mol Biol
Oberemok V, Laikova K, Ali J, Chachoua I, Gal'chinsky N.   +4 more
europepmc   +1 more source

A Novel AP2/ERF Transcription Factor Controls Trichome Initiation and Fruit Development in Cucumber

Plant Biotechnology Journal, EarlyView.
ABSTRACT Trichomes, the hair‐like outgrowths of the plant epidermis, are critical for defence, reproduction and development. However, the underlying molecular mechanisms governing their initiation remain elusive. Here, we identified CsGL2, an AP2/ERF transcription factor, as a key integrator controlling trichome initiation and fruit development in ...
Haifan Wen, Hui Du, Siqi Wang, Yiqun Weng, Juan Liu, Huanle He, Run Cai, Jian Pan, Junsong Pan   +8 more
wiley   +1 more source

Important Aspects of siRNA Design for Optimal Efficacy In Vitro and In Vivo. [PDF]

Int J Cell Biol
Bhakta-Yadav MS, Brown TL.
europepmc   +1 more source

Revisiting the Molecular Roadmap for Sugar Crops: Genome Reading, Trait Writing and Variety Redesigning

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sugar crops, including but not limited to sugarcane, sugar beet, sweet sorghum and stevia, are major sources of sugar production in the world. However, conventional breeding approaches, limited by long breeding cycles, low efficiency and restricted capacity to improve complex traits in sugar crops, are increasingly insufficient to address the ...
Peilin Wang, Qibin Wu, Wenzhi Wang, Prakash Lakshmanan, Yangrui Li, Khushi Muhammad, Yuguang Wang, Youxiong Que   +7 more
wiley   +1 more source

The impact of antisense oligonucleotide (ASO) therapeutics on the future of rare disease drug discovery. [PDF]

Expert Opin Drug Discov
Ruchi R, Gupta K, Verma R, Manautou J, Zhong XB, Bahal R.   +5 more
europepmc   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Dynamics of an RNase H-Responsive Tetrahedral DNA Nanostructure for Efficient Intracellular microRNA Inhibition. [PDF]

Bioconjug Chem
Martins ASG, Reis SD, Baboi R, Furlan F, Cortinhas J, Carvalho FA, Santos NC, Bath J, Benson E, Pêgo AP, Moreno PMD.   +10 more
europepmc   +1 more source