Results 11 to 20 of about 47,774 (288)
Gene and Antisense Delivery in Alcoholism Research [PDF]
Alcoholism: Clinical and Experimental Research, 2002 This article represents the proceedings of a symposium at the 2001 annual meeting of the Research Society on Alcoholism in Montreal, Canada. Drs. Yedy Israel and Fulton Crews were organizers and co‐chairpersons. The presentations were (1) Introduction to the symposium, by Yedy Israel; (2) Gene delivery to the brain, by Fulton T. Crews; (3) Gene therapy
Israel Jacard, Yedy +12 more
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Targeted delivery of antisense oligonucleotides by molecular conjugates [PDF]
Somatic Cell and Molecular Genetics, 1992 Antisense oligonucleotides efficiently inhibit gene expression in vitro; however, the successful therapeutic application of this technology in vivo will require the development of improved delivery systems. In this report we describe a technique that efficiently delivers antisense oligonucleotides into cells using molecular conjugates.
Bunnell, Bruce A. +2 more
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International Journal of Nanomedicine, 2015 Mingxing Wang, Bo Wu, Jason D Tucker, Peijuan Lu, Qilong Lu Department of Neurology, McColl-Lockwood Laboratory for Muscular Dystrophy Research, Cannon Research Center, Carolinas Medical Center, Charlotte, NC, USA Abstract: In this study, we ...
Wang M, Wu B, Tucker JD, Lu P, Lu Q
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International Journal of Nanomedicine, 2016 John P Hegarty,1 Jacek Krzeminski,2 Arun K Sharma,2 Diana Guzman-Villanueva,3 Volkmar Weissig,3 David B Stewart Sr1 1Deparment of Surgery, Pennsylvania State University College of Medicine Hershey, PA, USA; 2Department of Pharmacology, Penn State ...
Hegarty JP +5 more
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Antisense RNA Design, Delivery, and Analysis [PDF]
, 2022 This open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention.
core +5 more sources
Molecular Therapy: Nucleic Acids, 2023 Phosphorodiamidate morpholino oligonucleotide (PMO)-based antisense reagents cannot enter cells without the help of a delivery technique, which limits their clinical applications. To overcome this problem, self-transfecting guanidinium-linked morpholino (
Ujjal Das +8 more
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Advances in antisense oligonucleotide development for target identification, validation, and as novel therapeutics [PDF]
, 2008 Antisense oligonucleotides (As-ODNs) are single stranded, synthetically prepared strands of deoxynucleotide sequences, usually 18–21 nucleotides in length, complementary to the mRNA sequence of the target gene.
Alirio J. Melendez +3 more
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Duchenne Muscular Dystrophy: From Diagnosis to Therapy
Molecules, 2015 Duchenne muscular dystrophy (DMD) is an X-linked inherited neuromuscular disorder due to mutations in the dystrophin gene. It is characterized by progressive muscle weakness and wasting due to the absence of dystrophin protein that causes degeneration of
Maria Sofia Falzarano +3 more
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Polymersome delivery of siRNA and antisense oligonucleotides [PDF]
Journal of Controlled Release, 2009 siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers-but exposed positive charge is problematic in vivo. Here we demonstrate loading and functional delivery of RNAi and AON with non-ionic, nano-transforming polymersomes.
Younghoon, Kim +11 more
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Molecular Therapy: Nucleic Acids, 2016 A series of poly(esteramine)s (PEAs) constructed from low molecular weight polyethyleneimine (LPEI) and Pluronic were evaluated for the delivery of antisense oligonuclotides (AOs), 2′-O-methyl phosphorothioate RNA (2′-OMePS) and phosphorodiamidate ...
Mingxing Wang +5 more
doaj +1 more source