Results 191 to 200 of about 45,567 (253)

From Genomic Diagnosis to Personalized RNA Medicine: Advances in Next-Generation Sequencing and N-of-1 Antisense Oligonucleotide Therapies for Rare Genetic Diseases. [PDF]

Genes (Basel)
Rodriguez Carstens P, Moriyama H, Yokota T.   +2 more
europepmc   +1 more source

MtGRF8 interacts with MtSymCRK and prevents early bacteroid death during Medicago – Sinorhizobium symbiosis

New Phytologist, Volume 251, Issue 5, Page 2867-2887, September 2026.
MtSymCRK–MtGRF8‐14‐3‐3a, e, h and i functional model in R‐108 nodules. Summary In Medicago littoralis R‐108, Symbiotic CYSTEINE‐RICH RECEPTOR‐LIKE KINASE (MtSymCRK) is required to prevent defense reactions in symbiotic nodules during chronic infection.
Chaoyan Yin, Kévin Magne, Fathi Berrabah, Dario Monachello, Gautier Bernal, Kirankumar S. Mysore, Jiangqi Wen, Catherine Etchebest, Pascal Ratet, Véronique Gruber   +9 more
wiley   +1 more source

Nanotech meets antibiotics: nucleotide antibiotics delivered by lipid nanoparticles. [PDF]

Front Cell Infect Microbiol
Kim B, Kim D, Ryu CM.
europepmc   +1 more source

Structural and Functional Insights Into (S)‐5′‐C‐Guanidinopropyl Uridine‐Modified Oligonucleotides With 2′‐O‐Methyl and 2′‐Fluoro Substitutions for RNAi Therapeutics

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Novel (S)‐5′‐guanidinopropyl uridine analogs bearing 2′‐O‐methyl or 2′‐fluoro substitutions enhance nuclease resistance and mismatch discrimination while preserving A‐form RNA structure and potent RNAi activity. These modifications provide a promising strategy for improving the stability, specificity, and therapeutic potential of siRNA‐based medicines.
Sugahara Masaki, Elsayed M. Mahmoud, Shuichi Sakamoto, Yoshihito Ueno   +3 more
wiley   +1 more source

Harnessing CRISPR-dCas13Rx to identify novel antisense targets for therapeutic splicing modulation. [PDF]

Mol Ther Nucleic Acids
Singh RN, Alves CRR.
europepmc   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, Volume 13, Issue 43, 3 August 2026.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Weaknesses out of strength: PNA against the penicillin-binding proteins. [PDF]

Mol Ther Nucleic Acids
Wdowiak M.
europepmc   +1 more source

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Systemic distribution of tricyclo-DNA antisense oligonucleotide following intratracheal instillation in the mouse. [PDF]

NAR Mol Med
Laurent J, Deramaudt TB, Cloix R, Robin V, Beley C, Garcia L, Bonay M.   +6 more
europepmc   +1 more source