Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects [PDF]
Molecular Therapy: Nucleic AcidsNicotinamide N-methyltransferase (NNMT) is one of the methyltransferase family genes. It consumes S-adenosyl-l-methionine (SAM), which is required for DNA methylation and histone methylation for epigenetic regulation, to produce 1-methylnicotinamide from
Tomoaki Hara +13 more
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Rethinking antisense oligonucleotide therapeutics for amyotrophic lateral sclerosis [PDF]
Annals of Clinical and Translational NeurologyAntisense oligonucleotides, which are used to silence target genes, are gaining attention as a novel drug discovery modality for proteinopathies. However, while clinical trials for neurodegenerative diseases like amyotrophic lateral sclerosis have been ...
Daisuke Ito, Kensuke Okada
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When HERG-caused LQT2 encounters antisense oligonucleotide: is exon 6 skipping therapy plausible? [PDF]
Frontiers in PharmacologyGraphical AbstractThe unique in‐frame exon 6 of the HERG gene as a potential target for antisense oligonucleotide‐mediated exon skipping therapy.
Zequn Zheng, Zequn Zheng, Yongfei Song
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In-silico study of antisense oligonucleotide antibiotics [PDF]
PeerJ, 2023 Background The rapid emergence of antibiotic-resistant bacteria directly contributes to a wave of untreatable infections. The lack of new drug development is an important driver of this crisis.
Erica S. Chen, Eric S. Ho
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Molecules, 2021 The increase in antibacterial resistance is a serious challenge for both the health and defence sectors and there is a need for both novel antibacterial targets and antibacterial strategies.
Layla R. Goddard +9 more
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A perspective on oligonucleotide therapy: Approaches to patient customization
Frontiers in Pharmacology, 2022 It is estimated that the human genome encodes 15% of proteins that are considered to be disease-modifying. Only 2% of these proteins possess a druggable site that the approved clinical candidates target. Due to this disparity, there is an immense need to
Shikha Thakur +3 more
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Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD
Molecules, 2020 The hexanucleotide expansion GGGGCC located in C9orf72 gene represents the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD).
Tim Božič +4 more
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History of Research on Antisense Oligonucleotide Analogs
Substantia, 2021 In the search for novel therapeutics, antisense oligonucleotide (ASO) analogs have been a major focus of research for over 40 years. They use the antisense strategy, namely they have a nucleic acid base sequence that is complementary to a portion of a ...
Jack S. Cohen
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Polymerase-endonuclease amplification reaction (PEAR) for large-scale enzymatic production of antisense oligonucleotides. [PDF]
PLoS ONE, 2010 Antisense oligonucleotides targeting microRNAs or their mRNA targets prove to be powerful tools for molecular biology research and may eventually emerge as new therapeutic agents.
Xiaolong Wang +2 more
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RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications. [PDF]
PLoS ONE, 2015 The inhibitory potency of an antisense oligonucleotide depends critically on its design and the accessibility of its target site. Here, we used an RNA interference-guided approach to select antisense oligonucleotide target sites in the coding region of ...
Margit Mutso +10 more
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