Results 101 to 110 of about 102,021 (242)

Update on Gene Therapy in the Treatment of Hereditary Hearing Loss

Sensory Neuroscience, EarlyView.
Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He, Shanying Han, Xinghong Liu, Xiaotong Huang, Wen Yang, Xinghua Tang, Chuan Dong, Jiangang Fan   +7 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

NIR‐Induced Photoswitching Hybrid DNA Nanoconstruct‐Based Drug Delivery System for Spatiotemporal Control of Stem Cell Fate

Small, EarlyView.
NIR‐mediated photo‐switching drug delivery system for the remote‐control differentiation of NSCs. Left: NIR‐mediated curcumin release is induced by NIR‐to‐UV photon upconversion in a photo‐controllable manner. Curcumin is bound in the minor groove of the synthesized DNA construct containing AAP photo‐switchers. Right: The rational design of several AAP
Thanapat Pongkulapa, Ji Hye Yum, Callan D. McLoughlin, Brandon Conklin, Tomotaka Kumagai, Li Ling Goldston, Hiroshi Sugiyama, Soyoung Park, Ki‐Bum Lee   +8 more
wiley   +1 more source

In-silico study of antisense oligonucleotide antibiotics. [PDF]

PeerJ, 2023
Chen ES, Ho ES.
europepmc   +1 more source

Nucleic Acid‐Modified Nanoparticles for Cancer Therapeutic Applications

Small, EarlyView.
Nucleic acid‐modified nanoparticles act as functional hybrids for chemodynamic, photodynamic, photothermal, and gene therapy of cancer cells. These are exemplified with aptamer‐modified catalytic nanoparticles, photosensitizer‐oligonucleotide functionalized nanoparticles, drug‐loaded stimuli‐responsive nucleic acid‐caged nanoparticle carriers, and ...
Yunlong Qin, Xinghua Chen, Itamar Willner   +2 more
wiley   +1 more source

Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome

Small Science, EarlyView.
Both native and engineered extracellular vesicles (EVs) are served as promising therapeutic agents for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To circumvent the limitations of native EVs, various engineering strategies are adopted.
Zhengyan Gu, Wenjun Xue, Guanchao Mao, Zhipeng Pei, Jingjing Li, Mingxue Sun, Xinkang Zhang, Shanshan Zhang, Songling Li, Jinfeng Cen, Kai Xiao, Ying Lu, Qingqiang Xu   +12 more
wiley   +1 more source

Polymeric Giant Unilamellar Vesicles Support Longevity of Native Nuclei in Protocells

Small Science, EarlyView.
Native nuclei are isolated and incorporated into polymeric giant unilamellar vesicles (pGUVs) using microfluidics. Nucleated pGUVs retain nuclear integrity and function, providing a new platform to study the import process of peptide‐based multicompartment micelles via nuclear localization signals. This bottom‐up chimeric system lays the groundwork for
Lukas Heuberger, Arianna Balestri, Shabnam Tarvirdipour, Larisa E. Kapinos, Roderick Y. H. Lim, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan   +7 more
wiley   +1 more source

Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington's disease. [PDF]

Transl Neurodegener
Ou K, Jia Q, Li D, Li S, Li XJ, Yin P.
europepmc   +1 more source

Systemic Brain Delivery of Oligonucleotide Therapeutics Enhanced by Protein Corona‐Assisted DNA Cubes

Small Methods, EarlyView.
In vivo, screening of DNA nanostructures yields a cube‐shaped structure (D‐Cb) as a protein corona‐assisted platform for brain delivery of oligonucleotide therapeutics. D‐Cb effectively delivers polo‐like kinase 1 (PLK‐1) antisense oligonucleotides (ASO) to treat glioblastoma in an orthotopic mouse model, demonstrating its potential as a carrier for ...
Kyoung‐Ran Kim, Ji Hee Kang, Hien Bao Dieu Thai, Ji Hyun Back, Chengde Mao, Ji Eun Lee, Young Tag Ko, Dae‐Ro Ahn   +7 more
wiley   +1 more source

AmNA-Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer-Specific Chemosensitizer for Platinum Compounds. [PDF]

Cancer Sci
Uchibori Y, Suekuni M, Kokaji Y, Yoshida K, Kiyono T, Kasahara Y, Fujita M.   +6 more
europepmc   +1 more source