Results 121 to 130 of about 270,275 (243)

Investigation of the role of LRP in multidrug resistance [PDF]

, 1998
There have been many reports linking the overexpression of the lung resistance-related protein (LRP) with cross-resistance to chemotherapeutic drugs.
Byrne, Daragh
core  

Antisense c-myc oligonucleotide promotes chondrogenesis and enhances RA responsiveness of mouse limb mesenchymal cells in vitro

, 1994
To examine the role of c-myc protein during chondrogenesis, we exposed 11 day p.c. mouse limb mesenchymal cells to the antisense c-myc oligonucleotide in micromass culture.
Jun Motoyama, Eto, Kazuhiro, Kazuhiro Eto, Motoyama, Jun   +3 more
core   +1 more source

Tissue pharmacokinetics of antisense oligonucleotides

Molecular Therapy Nucleic Acids
Pharmacokinetics (PK) of antisense oligonucleotides (ASOs) is characterized by rapid distribution from plasma to tissue and slow terminal plasma elimination driven by re-distribution from tissue. Quantitative understanding of tissue PK and RNA knockdown for various ASO chemistries, conjugations, and administration routes is critical for successful drug
Erica Bäckström, Alessandro Bonetti, Per Johnsson, Stefan Öhlin, Anders Dahlén, Patrik Andersson, Shalini Andersson, Peter Gennemark   +7 more
openaire   +3 more sources

Inhibition of Smad7 With a Specific Antisense Oligonucleotide Facilitates TGF-β1-Mediated Suppression of Colitis

, 2006
Background & Aims: Defective transforming growth factor (TGF)-β1 signaling due to high levels of Smad7 is a feature of inflammatory bowel disease (IBD).
Marinaro, M, Giovanni Monteleone, MONTELEONE, GIOVANNI, MONTELEONE, IVAN, Boirivant, M, Palmieri, G, Giampiero Palmieri, Massimo Sanchez, MacDonald, TT, Caruso, R, Warren Strober, Thomas T. MacDonald, Strober, W, Mariarosaria Marinaro, Ivan Monteleone, Roberta Caruso, Pallone, F, Daniele Fina, PALLONE, FRANCESCO, Fina, D, PALMIERI, GIAMPIERO, Alfredo Colantoni, Colantoni, A, Monica Boirivant, Francesco Pallone, Monteleone, I, Di Giacinto, C, Claudia Di Giacinto, Monteleone, G, Sanchez, M   +29 more
core   +1 more source

Rapid effect on suckling of an oxytocin antisense oligonucleotide administered into rat supraoptic nucleus

, 1994
Suckling in the lactating rat (days 6-10 of lactation) was used to characterize the effects of intracerebral oxytocin (Oxt) antisense oligonucleotide treatment on the hypothalamo-neurohypophysial system.
I. Neumann, R. Landgraf, Q. J. Pittman, D. W. Porter   +3 more
core   +1 more source

Design of antisense oligonucleotides

Folia Pharmacologica Japonica, 2016
Satoshi, Obika, Yuuya, Kasahara
openaire   +3 more sources

Targeting the lung using siRNA and antisense based oligonucleotides

, 2008
The accessibility to topical administration through inhalation, combined with its large surface area, has led to speculation that the lung might offer an ideal target for the application of oligonucleotide based therapeutics.
Williams, A.E., Spink, K.G., Moschos, S.A., Lindsay, M.A.   +3 more
core  

Tailored antisense oligonucleotides designed to correct aberrant splicing reveal actionable groups of mutations for rare genetic disorders

Experimental and Molecular Medicine
Effective translation of rare disease diagnosis knowledge into therapeutic applications is achievable within a reasonable timeframe; where mutations are amenable to current antisense oligonucleotide technology.
Htoo A. Wai, Eliska Svobodova, Natalia Romero Herrera, Andrew G. L. Douglas, John W. Holloway, Francisco E. Baralle, Marco Baralle, Diana Baralle   +7 more
doaj   +1 more source

A WT1 antisense oligonucleotide inhibits proliferation and induces apoptosis in myeloid leukaemia cell lines

, 1996
The response of the CML-BC cell line, K562, the myelomonocytic cell line MM6 and the promyelocytic leukaemia cell line HL-60, to a 15 mer WT1 antisense oligonucleotide, targeted to the translation initiation site of the WT1 mRNA was examined.
Smith, P. J., Blackburn, DM, Algar, E. M., Bryson, G. J., Smith, SI, Khromykh, T, Khromykh, T., Algar, EM, Smith, S. I., Blackburn, D. M., Bryson, GJ, Smith, PJ   +11 more
core  

Advances in antisense oligonucleotide treatment for cancer. [PDF]

Jpn J Clin Oncol
Zhu L, Muhtar P, Goyama S, Yoshimi A.
europepmc   +1 more source