Results 81 to 90 of about 270,275 (243)
Schematic of the tandem antisense oligonucleotide approach.
, 2015 WT and Mut mRNA can interact with the gapmer or inhibitor, resulting in the formation of the most favorable thermodynamically duplexes (WT RNA/inhibitor and Mut RNA/gapmer).
Jolanta Lisowiec-Wachnicka (823327) +4 more
core +1 more source
When HERG-caused LQT2 encounters antisense oligonucleotide: is exon 6 skipping therapy plausible?
Frontiers in PharmacologyGraphical AbstractThe unique in‐frame exon 6 of the HERG gene as a potential target for antisense oligonucleotide‐mediated exon skipping therapy.
Zequn Zheng, Zequn Zheng, Yongfei Song
doaj +1 more source
Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells
Molecular Therapy: Nucleic Acids, 2018 Glioblastoma stem cells (GSCs) are invasive, treatment-resistant brain cancer cells that express downregulated in renal cell carcinoma (DRR), also called FAM107A, a genetic driver of GSC invasion.
Amy E. Arnold +7 more
semanticscholar +1 more source
Rethinking antisense oligonucleotide therapeutics for amyotrophic lateral sclerosis
Annals of Clinical and Translational NeurologyAntisense oligonucleotides, which are used to silence target genes, are gaining attention as a novel drug discovery modality for proteinopathies. However, while clinical trials for neurodegenerative diseases like amyotrophic lateral sclerosis have been ...
Daisuke Ito, Kensuke Okada
doaj +1 more source
Emerging antisense oligonucleotide and viral therapies for ALS
Current Opinion in Neurology, 2018 Purpose of review Amyotrophic lateral sclerosis (ALS) is a rapidly fatal disease for which there is currently no effective therapy. The present review describes the current progress of existing molecular therapies in the clinical trial pipeline and ...
Cindy V Ly, T. Miller
semanticscholar +1 more source
, 2009 Synthetic oligonucleotides are contaminated with highly homologous failure sequences. Oligonucleotide synthesis is difficult to scale up because it requires expensive equipments, hazardous chemicals, and tedious purification process.
Deming Gou, Xiaolong Wang
core
, 2016 A new modification of 2−5A-antisense, 2−5A-iso-antisense, has been developed based on a reversal of the direction of the polarity of the antisense domain of a 2−5A-antisense composite nucleic acid. This modification was able to anneal with its target RNA
Wei Xiao (16583) +6 more
core +1 more source
, 2010 Context: The GH receptor (GHR) pseudoexon 6 Psi defect is a frequent cause of GH insensitivity (GHI) resulting from a non-functioning GH receptor (GHR). It results in a broad range of phenotypes and may also be present in patients diagnosed as idiopathic
Srirangalingam, U +4 more
core
Meeting report: antisense oligonucleotides.
Haematologica, 1994 The use of antisense oligonucleotides as a therapeutic tool in modulating gene expression represents a newly established strategy for treating diseases. Such oligomers may be designed to complement a region of a specific gene or messenger RNA. Using this approach, oligonucleotides can serve as a potential block of transcription or translation through ...
G, Martinelli, S, Ferrari
openaire +3 more sources
Journal of Plant Protection Research, 2019 5.8S ribosomal RNA plays an important role in protein synthesis and eukaryotic ribosome translocation. Contact DNA insecticides based on antisense fragments of 5.8S ribosomal RNA gene of gypsy moth Lymantria dispar L.
Volodymyr V. Oberemok +9 more
doaj +1 more source