Results 151 to 160 of about 266,614 (380)

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou   +7 more
wiley   +1 more source

Rapid Synthesis and Diversification of Thymine‐Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions

Angewandte Chemie, EarlyView.
Several processes are reported that enable the rapid diversification of bridged nucleoside analogues (NAs) starting from a common and readily prepared fluorohydrin. Also, several clinically relevant bridged nucleosides are now prepared in as few as three synthetic steps, creating new opportunities for examining structure‐activity relationships within ...
Cohan Huxley, Ethan Fung, Bara Singh, Guillermo Caballero‐García, Garrett Muir, Steven M. Silverman, Louis‐Charles Campeau, Robert Britton   +7 more
wiley   +2 more sources

Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis

Drug Design, Development and Therapy, 2019
Veena Mathew,1 Annabel K Wang1,2 1Department of Neurology, UCI ALS and Neuromuscular Center, University of California, Irvine, Orange, CA, USA; 2Neurology Section, Tibor Rubin VA Medical Center, Long Beach, CA, USA Abstract: Hereditary transthyretin ...
Mathew V, Wang AK
doaj  

Durable vision improvement after a single treatment with antisense oligonucleotide sepofarsen: a case report

Nature Network Boston, 2021
A. Cideciyan, S. Jacobson, A. Ho, Alexandra V. Garafalo, A. J. Roman, A. Sumaroka, A. Krishnan, M. Świder, Michael R. Schwartz, A. Girach   +9 more
semanticscholar   +1 more source

ASO Therapy Targeting STAU2 to Inhibit Pancreatic Ductal Adenocarcinoma Progression and Metastasis by Regulating the PALLD‐Mediated EMT Signaling Pathway

Advanced Science, EarlyView.
This study identifies STAU2 as an oncogenic RNA‐binding protein (RBP) with elevated expression in pancreatic ductal adenocarcinoma (PDAC), where its high levels are significantly correlated with metastatic progression. It elucidates that STAU2 directly binds and regulates PALLD, while mediating the functional role of IQGAP1, thereby driving metastasis ...
Jiayu Ding, Hao Shen, Jiaying Ji, Jiaxing Li, Zhongrui Shi, Xuejiao Wang, Bangbang Li, Yi Hou, Wenjian Min, Chengliang Sun, Kai Yuan, Yasheng Zhu, Liping Wang, Shun‐Qing Liang, Wenbin Kuang, Xiao Wang, Peng Yang   +16 more
wiley   +1 more source

Bispecific DNA‐Peptide Probes for Targeting Receptor Pairs on Live Cells

Angewandte Chemie, EarlyView.
DNA duplex‐programmed presentation of two different (cyclo)peptides provides bispecific agents that recognize unique fingerprints of cells through improved avidity and specificity. Bispecific DNA‐cyclopeptide complexes enabled a cell‐specific targeting and internalization of cytotoxic payload.
Pritam Ghosh, Huyen Dinh, Alen Kocak, Amal K. Homer, Peter Bou‐Dip, Sophie Schlicht, Oliver Seitz   +6 more
wiley   +2 more sources

Phosphorothioate antisense oligonucleotides against basic fibroblast growth factor inhibit anchorage-dependent and anchorage-independent growth of a malignant glioblastoma cell line. [PDF]

, 1992
Paul R. Murphy, Yuji Sato, Rai Knee
openalex   +1 more source

Antisense Oligonucleotide Therapy for Neurodevelopmental Disorders

Developmental Neuroscience, 2021
Sophie F. Hill, M. Meisler
semanticscholar   +1 more source

Long Non‐Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma

Advanced Science, EarlyView.
The limited understanding of IGFR pathway activation hinders its clinical application in HCC. Here, IGFRIL is identified as a novel non‐coding activator of the IGF1R, which recruits PTBP1 to destabilize IGFBP3 mRNA and activates IGF1R, and proposes IGFRIL as a novel actionable target for HCC patients.
Jing Zhang, Chengming Gao, Haibei Li, Yuying Chen, Liting Yang, Qian Jin, Lan Feng, Xia Wang, Xinyi Liu, Hongxia Chen, Rong Ye, Yuanchao Xue, Huiyun Wang, Musheng Zeng, Ming Yang, Huaiqiang Ju, Chengzhi Gao, Guangming Zhou, Qi Zhang, Qian Zhang, Geng Qin, Yuanfeng Li, Yahui Wang, Aiqing Yang, Anfeng Si, Qingfeng Song, Fuchu He, Pengbo Cao, Gangqiao Zhou   +28 more
wiley   +1 more source

A phosphorothioate oligonucleotide blocks reverse transcription via an antisense mechanism [PDF]

, 1994
Claudine Boiziau, Serge Moreau, Jean‐Jacques Toulmé   +2 more
openalex   +1 more source