Results 151 to 160 of about 102,021 (242)
Rapid Communications in Mass Spectrometry, Volume 39, Issue 13, 15 July 2025.ABSTRACT Rationale Oligonucleotides have emerged as an important new class of therapeutic. Due to their structural complexity, this presents significant challenges for the development of analytical methods to characterise and determine their impurity profile.
Mollie A. Glenister +4 more
wiley +1 more source
Recent Progress of Antisense Oligonucleotide Therapy for Superoxide-Dismutase-1-Mutated Amyotrophic Lateral Sclerosis: Focus on Tofersen. [PDF]
Genes (Basel)Moriyama H, Yokota T.
europepmc +1 more source
MicroRNA‐100‐5p Exacerbates Myocardial Ischemia–Reperfusion Injury Through Downregulation of PRMT5
The FASEB Journal, Volume 39, Issue 11, 15 June 2025.MiR‐100‐5p overexpression downregulates PRMT5, leading to increased PTEN activity and reduced AKT signaling. This molecular cascade promotes cardiomyocyte apoptosis, enhances fibrotic remodeling, and exacerbates cardiac dysfunction following myocardial ischemia–reperfusion injury.
Zhenya Wang +9 more
wiley +1 more source
Antisense oligonucleotide therapeutic approach for Timothy syndrome. [PDF]
NatureChen X +15 more
europepmc +1 more source
Articoli Schwarz(strand_seclection) / Grishok(stRNA&RNAi) / Han(microprocessor) [PDF]
, 2012 Danielli, Alberto
core
Advanced Science, Volume 12, Issue 21, June 5, 2025.Lysine demethylase 6A (KDM6A), an epigenetic regulator expressed in hematopoietic stem and progenitor cells (HSPCs), plays a critical role in hematopoietic homeostasis. Deficiency of KDM6A induces myeloid lineage skewing and drives the development of a chronic myelomonocytic leukemia (CMML)‐like disease.
Huiqiao Chen +11 more
wiley +1 more source
Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration
Advanced Science, Volume 12, Issue 21, June 5, 2025.The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan +16 more
wiley +1 more source
Advanced Science, Volume 12, Issue 21, June 5, 2025.PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao +11 more
wiley +1 more source
Bioanalysis of free antisense oligonucleotide payload from antibody-oligonucleotide conjugate by hybridization LC-MS/MS. [PDF]
BioanalysisJiang D, Li P, Yuan L.
europepmc +1 more source
Advanced Science, Volume 12, Issue 21, June 5, 2025.The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou +11 more
wiley +1 more source