Results 201 to 210 of about 263,255 (408)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Phosphorothioate antisense oligonucleotides against basic fibroblast growth factor inhibit anchorage-dependent and anchorage-independent growth of a malignant glioblastoma cell line. [PDF]

, 1992
Paul R. Murphy, Yuji Sato, Rai Knee
openalex   +1 more source

Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges

Advanced Genetics, EarlyView.
This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley   +1 more source

lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. [PDF]

, 2013
Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type determination and tissue homeostasis, their potential involvement in regulated gene transcription programs remains rather poorly ...
Evans, Christopher P, Jin, Chunyu, Li, Wenbo, Lin, Chunru, Meng, Da, Merkurjev, Daria, Ohgi, Kenneth A, Rosenfeld, Michael G, Tanasa, Bogdan, Yang, Joy C, Yang, Liuqing, Zhang, Jie   +11 more
core  

Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms [PDF]

, 1994
Olivier Zelphati, Jean‐Louis Imbach, Nathalie Signoret, Gerald Zon, Bernard Rayner, Lee Leserman   +5 more
openalex   +1 more source

Antisense oligonucleotides to the p65 subunit of NF-kappa B block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes [PDF]

, 1993
J A Sokoloski, AC Sartorelli, C.-G. ROSÉN, Ramaswamy Narayanan   +3 more
openalex   +1 more source

Racing toward the future of chronic hepatitis B management: Achieving functional cure and enhancing hepatocellular carcinoma surveillance through precision medicine

Interdisciplinary Medicine, EarlyView.
Novel biomarker emergence plays a critical role in improving CHB management. Advances in sensitive detection methods, AI, and large‐scale data platforms have independently contributed to biomarkers while driving the development of multi‐omics approaches.
Yaru Shi, Rong Fan
wiley   +1 more source

Nanodiamond as a vector for siRNA delivery to Ewing sarcoma cells

, 2011
We investigated the ability of diamond nanoparticles (nanodiamonds, NDs) to deliver small interfering RNA (siRNA) in Ewing sarcoma cells, in the perspective of in vivo anti-cancer nucleic acid drug delivery.
Barnard, Bertrand, Bolte, Boudou, Caliceti, Chang, Chen, Choosakoonkriang, Chow, Chung, Creusat, Dantelle, de Martimprey, Diaz-Lopez, El Badawy, Elhamess, Faklaris, Fattal, Guan, Horcajada, Huang, Huang, Kaiser, Kurosaki, Liang, Liu, Maksimenko, Maksimenko, Mohan, Nakada, Pouton, Qi, Ramon, Rondin, Schrand, Schrand, Simovic, Tanaka, Tang, Toub, Vaijayanthimala, Vial, Xia, Xu, Yuan, Yuan, Zhang, Zoubek   +47 more
core   +3 more sources

c-myc antisense oligonucleotides inhibit the colony-forming capacity of Colo 320 colonic carcinoma cells. [PDF]

, 1992
James F. Collins, P Herman, C Schuch, Grover C. Bagby   +3 more
openalex   +1 more source

Circulating let‐7 Predicts Hepatic Fibrogenesis of 12‐Month Post‐Nucleos(t)ide Analog Treatment in Patients With Hepatitis B Virus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Chronic hepatitis B virus (HBV) infection is associated with potential complications of liver cirrhosis and hepatocellular carcinoma. To date, there are no effective and noninvasive clinical markers that can predict the risk of liver fibrosis early and accurately in chronic hepatitis B (CHB) patients treated with nucleos(t)ide analogs (NAs ...
Yi‐Shan Tsai, Po‐Cheng Liang, Yi‐Hung Lin, Tyng‐Yuan Jang, Yu‐Ju Wei, Po‐Han Chen, Jia‐Ning Hsu, Meng‐Hsuan Hsieh, Ming‐Yen Hsieh, Chih‐Wen Wang, Zu‐Yau Lin, Ming‐Lun Yeh, Chung‐Feng Huang, Jee‐Fu Huang, Ming‐Lung Yu, Wan‐Long Chuang, Chia‐Yen Dai   +16 more
wiley   +1 more source