Results 211 to 220 of about 171,175 (241)

Phosphorothioate antisense oligonucleotide induced innate immune activation is attenuated by tryptophan oxidation products. [PDF]

Nucleic Acids Res
Pytte J, Saldana L, Zhang W, Skourti-Stathaki K, Crooke ST.   +4 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Antisense oligonucleotide treatment following viral delivery of artificial SOD1-targeting miRNA shows improved efficacy in SOD1-G93A mice. [PDF]

Mol Ther Adv
Hawley ZCE, Guise AJ, Pardo ID, Chowdhury T, Hana S, Zavodszky MI, Engle L, Wiltberger K, Bartlett D, Raitcheva D, Bommegowda S, Lee WH, Chen SK, Sheehy A, Driscoll R, Peterson M, Sebalusky J, Hamann S, Marsh G, Doherty J, Chicoine KE, Cundiff P, Dwyer S, Clarner P, Zeng W, Ferretti D, Tuczkewycz T, Isaza I, Patrovanie M, Mcgladrigan C, Chu J, Morrison JP, Arnold HM, Shen S, Hurt JA, Trapa P, Graham DL, Plowey ED, Lo SC.   +38 more
europepmc   +1 more source

Fragment Coverage: Unified Visualization and Quantitative Assessment of MS/MS Fragmentation Supports Metabolite Identification in Macromolecule Drug Metabolism Studies

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale Peptides and oligonucleotides are increasingly used as therapeutic agents, making the identification and structural elucidation of their metabolites a critical step in drug development. Liquid chromatography–mass spectrometry (LC‐MS/MS) is the primary analytical technique for this purpose; however, extensive backbone fragmentation ...
Paula Cifuentes, Albert Garriga, Fabien Fontaine, Ismael Zamora   +3 more
wiley   +1 more source

Development of an exon 27-skipping antisense oligonucleotide as a targeted therapy for refractory skin ulcers in Werner syndrome. [PDF]

Mol Ther Nucleic Acids
Man Z, Asano S, Kakutani T, Kiyoshi A, Hino K, Ikeda A.   +5 more
europepmc   +1 more source

Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema. [PDF]

CPT Pharmacometrics Syst Pharmacol
Diep JK, Liu M, Singh P, Dorow S, Cohn DM, Bordone L, Newman KB, Gao X.   +7 more
europepmc   +1 more source

CTLA-4 Antisense Oligonucleotide Contributes to Enhanced Immunogenicity of an Adjuvanted Recombinant <i>Sporothrix</i> spp. Enolase Antigen. [PDF]

Vaccines (Basel)
Momente GJ, Portuondo DL, Deus AF, Curti Gonçalves MR, Piccineli FL, de Oliveira Campos TPC, Téllez-Martínez D, Carlos IZ, Batista-Duharte A.   +8 more
europepmc   +1 more source

Improved targeted delivery of antisense oligonucleotide with an antibody mask. [PDF]

Nucleic Acids Res
Hsia HE, Zanini C, Simonneau C, Fraidling J, Kraft TE, Mayer K, Sommer A, Indlekofer A, Wirth T, Benz J, Georges G, Langer LM, Gassner C, Larraillet V, Lohmann S, Koller E, Mansø M, Ravn J, Hofer K, Emrich T, Niewöhner J, Schumacher F, Brinkmann U.   +22 more
europepmc   +1 more source