Results 201 to 210 of about 270,275 (243)
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Progress in Antisense Oligonucleotide Therapeutics
Annual Review of Pharmacology and Toxicology, 1996The past several years have seen substantial progress in the development of antisense oligonucleotides as pharmacological tools and as therapeutic agents. With properly designed and executed experiments, it has been possible to demonstrate selective inhibition of gene expression, owing to an antisense mechanisms of action both in cell culture-based ...
S T, Crooke, C F, Bennett
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Antisense and/or Immunostimulatory Oligonucleotide Therapeutics
Current Cancer Drug Targets, 2001Antisense technology, which is based on a simple and rational principle of Watson-Crick complementary base pairing of a short oligonucleotide with the targeted mRNA to downregulate the disease-causing gene product, has progressed tremendously in the last two decades.
S, Agrawal, E R, Kandimalla
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An oral antisense oligonucleotide for PCSK9 inhibition
Science Translational Medicine, 2021Peter Gennemark +27 more
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Seminars in cancer biology, 1992
Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, down-regulation of oncogene ...
CALABRETTA, Bruno, Skorski T, Zon G.
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Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, down-regulation of oncogene ...
CALABRETTA, Bruno, Skorski T, Zon G.
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Antisense oligonucleotides as antiviral agents
Trends in Biotechnology, 1992Antisense oligonucleotides are an attractive potential alternative to conventional drugs as antiviral agents. A major advantage is the relatively simple rational design of oligonucleotides which should bind only to specific nucleic acid sequences, compared with conventional drugs which are frequently targeted against sites of unknown structure in ...
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Innovations in the Use of Antisense Oligonucleotides
Annals of the New York Academy of Sciences, 1990The use of antisense oligonucleotides for controlling genetic expression has recently received widespread attention, especially as a new class of potential chemotherapeutic agents. This coupled with the urgency of developing new effective therapies for acquired immunodeficiency syndrome (AIDS) has led to various antisense studies dealing with human ...
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Antisense oligonucleotide strategies in physiology
Molecular and Cellular Endocrinology, 1994Antisense oligonucleotides can inhibit gene expression in living cells by binding to complementary sequences of DNA, RNA or mRNA. The mechanisms include inhibition of RNA synthesis, RNA splicing, mRNA export, binding of initiation factors, assembly of ribosome subunits and of sliding of the ribosome along the mRNA coding sequence.
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Antisense oligonucleotides as therapeutics for hyperlipidaemias
Expert Opinion on Biological Therapy, 2005Hyperlipidaemia, due to elevations of low-density lipoprotein cholesterol (LDL-C) or triglycerides (TGs), is recognised as a significant risk factor contributing to the development of coronary heart disease (CHD), the leading cause of morbidity and mortality in the Western world.
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An antisense oligonucleotide to target the RAAS
Nature Reviews Cardiology, 2021Fernández-Ruiz Irène
exaly