Results 231 to 240 of about 131,722 (303)

LINC00240 Knockdown Suppresses the Proliferation, Migration, and Invasion of Ovarian Cancer Cells Through the miR‐30c‐5p/P4HA2 Axis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Ovarian cancer is a particularly lethal malignancy often diagnosed at advanced stages, highlighting the urgent need for novel therapeutic strategies. This study investigates the expression and functional role of LINC00240, miR‐30c‐5p, and P4HA2 in ovarian cancer pathogenesis.
Yunjie Tian, Jianlei Wu, HaiBo Zhang
wiley   +1 more source

Urine‐Derived iPSC Neurospheres Uncover Proteomic Correlates of Clinical Severity in Dravet Syndrome

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Urine epithelial cells from Dravet syndrome (DS) patients carrying distinct SCN1A variants were reprogrammed into induced pluripotent stem cells (iPSCs) and differentiated into neural stem cells (NSCs) to generate patient‐derived neurospheres. Three neurosphere lines were analyzed in biological triplicates using isobaric quantitative proteomics ...
Michele Martins, Guillaume Nugue, Andrey Aguiar, Leticia R. Q. Souza, Paulo V. Abrantes, Julia Rodrigues Trajano, Mariana Stelling, Magno Junqueira, Stevens Rehen, Marília Zaluar P. Guimarães   +9 more
wiley   +1 more source

Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux. [PDF]

Int J Oral Sci
Ni N, Wang M, Yuan Z, Zhang L, Cai J, Du Q, Li P, Gao C, Zhang H, Li Y, Yuan H.   +10 more
europepmc   +1 more source

Fascinating single‐cell red algae: models for evolution and adaptation

New Phytologist, Volume 250, Issue 3, Page 1424-1437, May 2026.
Summary The unicellular red algae, Cyanidiophyceae, that diverged early during Archaeplastida (algal and plant) evolution, occupy a variety of extreme habitats that are inhospitable for most other eukaryotes. With the use of modern genomics and genetics methods, Cyanidiophyceae show a remarkable taxonomic diversity, share haplodiplophasic life cycles ...
Frédéric Berger, Debashish Bhattacharya, Chung Hyun Cho, Seok‐Wan Choi, Julia Van Etten, Shunsuke Hirooka, Tzu‐Yen Huang, Kyle J. Lauersen, Yongsung Lee, Shao‐Lun Liu, Shin‐ya Miyagishima, Stephen D. Rader, Daniel Schubert, Hwan Su Yoon   +13 more
wiley   +1 more source

Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington's disease. [PDF]

Transl Neurodegener
Ou K, Jia Q, Li D, Li S, Li XJ, Yin P.
europepmc   +1 more source

In Vitro Structure-Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases. [PDF]

Pharmacol Res Perspect
Lovrić J, Yan J, Li X, Karlsborn T, Bood M, Dahlén A, Hilgendorf C, Bhatt DK.   +7 more
europepmc   +1 more source

Mass Spectrometry Imaging Reveals the Distribution of a GABRG2 Targeting Antisense Oligonucleotide and Its Functional Effect in Rat Brain. [PDF]

ACS Chem Neurosci
van der Vloet L, Mohren R, Bouillod C, Da Violante G, Isin EM, Heeren RMA, Barbier Saint Hilaire P, Vandenbosch M.   +7 more
europepmc   +1 more source

Antisense oligonucleotide targeting the E3 ligase RFFL potentiates CFTR modulator efficacy in CF primary bronchial epithelial cells. [PDF]

Mol Ther Nucleic Acids
Hinata D, Kai Y, Fukuda R, Kamada Y, Kasahara Y, Sasaki K, Yoshida T, Obika S, Inoue T, Okiyoneda T.   +9 more
europepmc   +1 more source

A Case Study of Model-Informed Drug Development of a Novel PCSK9 Antisense Oligonucleotide. Part 2: Phase 2 to Phase 3. [PDF]

CPT Pharmacometrics Syst Pharmacol
Knöchel J, Nilsson C, Carlsson B, Hofherr A, Johanson P, Rydén-Bergsten T, Hamrén B, Rekić D.   +7 more
europepmc   +1 more source

AmNA-Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer-Specific Chemosensitizer for Platinum Compounds. [PDF]

Cancer Sci
Uchibori Y, Suekuni M, Kokaji Y, Yoshida K, Kiyono T, Kasahara Y, Fujita M.   +6 more
europepmc   +1 more source