Results 241 to 250 of about 263,255 (408)

Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides. [PDF]

, 1996
Masashi Matsuda, J G Park, D C Wang, Sharon Hunter, Paul Chien, Alan D. Schreiber   +5 more
openalex   +1 more source

Steroid‐Modulated Transcription Synergistically Forms DNA Double‐Strand Breaks With Topoisomerase II Inhibitor

Cancer Science, EarlyView.
Through our exploration of the synergistic effects of drug combinations for potential clinical applications, we found that steroids potentiate the anticancer effects of etoposide, a topoisomerase II inhibitor. Steroids, when combined with etoposide, increase DNA double‐strand breaks not via DNA repair inhibition but transcriptional modulation ...
Ying Zhao, Tetsuro Hisayoshi, Doudou Zhang, Saaya Suzuki, Takashi Watanabe, Atsuo Kobayashi, Qianqian Guo, Yukihide Momozawa, Takashi Shimokawa, Shunsuke Kato, Yoshio Miki, Shigeaki Sunada   +11 more
wiley   +1 more source

Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington's disease. [PDF]

Transl Neurodegener
Ou K, Jia Q, Li D, Li S, Li XJ, Yin P.
europepmc   +1 more source

Altered mRNA Splicing and Inhibition of Human E-selectin Expression by an Antisense Oligonucleotide in Human Umbilical Vein Endothelial Cells [PDF]

, 1996
Thomas P. Condon, C. Frank Bennett
openalex   +1 more source

Polarity Gene PARD6B Promotes Tumor Growth of Colorectal Cancer via Increasing MYC Expression

Cancer Science, EarlyView.
Partitioning Defective 6B (PARD6B), a polarity gene, functions as a scaffold node for the Par protein complex. In this study, we showed that highly expressed PARD6B could promote CRC growth by upregulating MYC expression while suppressing miR‐34c expression.
Kosuke Hirose, Takaaki Masuda, Hajime Otsu, Taro Tobo, Kiyotaka Hosoda, Tadashi Abe, Yusuke Nakano, Masahiro Hashimoto, Takanari Tatsumi, Tomohiko Ikehara, Takashi Ofuchi, Shinsaku Itoyama, Yuki Ando, Yasuo Tsuda, Yusuke Yonemura, Keishi Sugimachi, Eiji Oki, Tomoharu Yoshizumi, Koshi Mimori   +18 more
wiley   +1 more source

AmNA-Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer-Specific Chemosensitizer for Platinum Compounds. [PDF]

Cancer Sci
Uchibori Y, Suekuni M, Kokaji Y, Yoshida K, Kiyono T, Kasahara Y, Fujita M.   +6 more
europepmc   +1 more source

Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides.

, 1993
Z. Dominski, R. Kole
openalex   +2 more sources

Sustained reduction of neointima with c-myc antisense oligonucleotides in saphenous vein grafts [PDF]

, 1998
John D. Mannion, Michael L. Ormont, Michael G. Magno, James E. O’Brien, Yi Shi, Andrew Zalewski   +5 more
openalex   +1 more source

Longitudinal Visual Biomarkers in Dominant Optic Atrophy: A Systematic Review and Meta‐Analysis

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Dominant Optic Atrophy (DOA) causes slowly progressive visual decline usually beginning in childhood. As new therapies come to clinical trial, the choice of biomarkers to be used as clinical trial endpoints has become a critical question to be addressed. Methods We undertook a systematic review and meta‐analysis of studies reporting
Christopher A. Ovens, John R. Grigg, Clare L. Fraser   +2 more
wiley   +1 more source

Anti-TNF-α antisense-oligonucleotide-conjugated PLG nanoparticles protect transplanted islets. [PDF]

Mol Ther Methods Clin Dev
Bealer EJ, Padgaonkar N, Crumley K, Saito E, Beekman Z, DeKorte A, Prakash TP, Revenko A, Shea LD.   +8 more
europepmc   +1 more source