Results 291 to 300 of about 275,477 (365)

Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid

Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.
This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile, Maria Teresa Cerasa, Antonia D'Aniello, Michele Saviano, Maria Moccia   +4 more
wiley   +1 more source

Splice-switching antisense oligonucleotides for pediatric neurological disorders. [PDF]

Front Mol Neurosci
Zhang X.
europepmc   +1 more source

MicroRNA‐100‐5p Exacerbates Myocardial Ischemia–Reperfusion Injury Through Downregulation of PRMT5

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
MiR‐100‐5p overexpression downregulates PRMT5, leading to increased PTEN activity and reduced AKT signaling. This molecular cascade promotes cardiomyocyte apoptosis, enhances fibrotic remodeling, and exacerbates cardiac dysfunction following myocardial ischemia–reperfusion injury.
Zhenya Wang, Tong‐You Wade Wei, Jo‐Mei Maureen Chen, Ke Zhang, Yiwei Zhang, Huiting Shi, Hsiang‐Chun Su, I‐Shan Hsieh, Chang‐Tze Ricky Yu, Guo‐Jun Zhao   +9 more
wiley   +1 more source

Therapeutic effect of intracolonically administered nuclear factorκB (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis

, 2000
Mitsuyuki Murano, Kentaro Maemura, I Hirata, Ken Toshina, Takeshi Nishikawa, Norihiro Hamamoto, S. Sasaki, Osamu Saitoh, Ken‐ichi Katsu   +8 more
openalex   +2 more sources

A NOTCH3 pathogenic variant influences osteogenesis and can be targeted by antisense oligonucleotides in induced pluripotent stem cells. [PDF]

PLoS One
Canalis E, Yu J, Schilling L, Jafar-Nejad P, Carrer M.   +4 more
europepmc   +1 more source

Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly- l -glutamate/glutamine cell wall structure, and bacterial replication

, 2000
Günter Harth, Paul C. Zamecnik, Jinyan Tang, David Tabatadze, Marcus A. Horwitz   +4 more
openalex   +1 more source

Exploring precision therapeutics: computational design of antisense oligonucleotides targeting AXL gene transcripts in multiple sclerosis treatment management. [PDF]

Front Chem
Shreevatsa B, Nagaraj A, Dharmashekar C, Jain A, Harendra B, Siddalingegowda SV, Al-Mazroua HA, Ahmad SF, Prasad SK, Srinivasa C, Shivamallu C, Kollur SP.   +11 more
europepmc   +1 more source

Efficacy, biodistribution and safety comparison of chemically modified antisense oligonucleotides in the retina. [PDF]

Nucleic Acids Res
Vázquez-Domínguez I, Anido AA, Duijkers L, Hoppenbrouwers T, Hoogendoorn ADM, Koster C, Collin RWJ, Garanto A.   +7 more
europepmc   +1 more source

Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system. [PDF]

Mol Ther
Moazami MP, Rembetsy-Brown JM, Sarli SL, McEachern HR, Wang F, Ohara M, Wagh A, Kelly K, Krishnamurthy PM, Weiss A, Marosfoi M, King RM, Motwani M, Gray-Edwards H, Fitzgerald KA, Brown RH, Watts JK.   +16 more
europepmc   +1 more source

Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome. [PDF]

Alzheimers Dement
Chen XQ, Zuo X, Becker A, Mante M, Florio JB, Jadhav SG, Albay R, Johnstone A, Karachentsev D, Rissman R, Zhao H, Dowdy SF, Mobley WC.   +12 more
europepmc   +1 more source