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Antisense and Nucleic Acid Drug Development, 1997
Antisense nucleic acids comprise short-chain synthetic oligonucleotides, often oligodeoxyribonucleotides (ODN) of less than approximately 30 nucleotides and substantially longer sequences formed by ribonucleic acids (RNA). Both groups differ with respect to several properties, including their generation, the mode of delivery, and their structure ...
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Antisense nucleic acids comprise short-chain synthetic oligonucleotides, often oligodeoxyribonucleotides (ODN) of less than approximately 30 nucleotides and substantially longer sequences formed by ribonucleic acids (RNA). Both groups differ with respect to several properties, including their generation, the mode of delivery, and their structure ...
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Antisense Rnas And Epigenetic Regulation
Epigenomics, 2010Antisense RNA is the first noncoding RNA found to have a regulatory function. With the advances of biological science, it has been recognized that the function of antisense RNAs is not only limited to post-transcriptional regulation, but extends to transcriptional regulation of various important genes leading to epigenetic changes in DNA methylation ...
Isabelle, Cui, Hengmi, Cui
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As Antisense RNA Gets Intronic
OMICS: A Journal of Integrative Biology, 2005Recent work describing the transcriptional output of the human genome points to the existence of a significant number of non-coding RNA transcripts coming from intronic regions, with a fraction of these being oriented antisense relative to the protein-coding mRNA of the known gene.
Eduardo M, Reis +3 more
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RNA–RNA Interaction Prediction and Antisense RNA Target Search
Journal of Computational Biology, 2005Recent studies demonstrating the existence of special noncoding "antisense" RNAs used in post transcriptional gene regulation have received considerable attention. These RNAs are synthesized naturally to control gene expression in C. elegans, Drosophila, and other organisms; they are known to regulate plasmid copy numbers in E. coli as well. Small RNAs
Can Alkan +4 more
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Trends in Genetics, 2002
In recent years, systematic searches of both prokaryote and eukaryote genomes have identified a staggering number of small RNAs, the biological functions of which remain unknown. Small RNA-based regulators are well known from bacterial plasmids. They act on target RNAs by sequence complementarity; that is, they are antisense RNAs.
E.Gerhart H Wagner, Klas Flärdh
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In recent years, systematic searches of both prokaryote and eukaryote genomes have identified a staggering number of small RNAs, the biological functions of which remain unknown. Small RNA-based regulators are well known from bacterial plasmids. They act on target RNAs by sequence complementarity; that is, they are antisense RNAs.
E.Gerhart H Wagner, Klas Flärdh
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Nature Chemical Biology, 2007
RNA interference provides powerful tools for controlling gene expression in cultured cells. Whether RNAi will provide similarly powerful drugs is unknown. Lessons from development of antisense oligonucleotide drugs may provide some clues.
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RNA interference provides powerful tools for controlling gene expression in cultured cells. Whether RNAi will provide similarly powerful drugs is unknown. Lessons from development of antisense oligonucleotide drugs may provide some clues.
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Antisense RNA therapy for CML — An hypothesis
Medical Hypotheses, 1991CML, a myeloproliferative clonal disorder of myeloid stem cells, is characterized by the consistent presence of a bcr-c-abl fusion gene which is formed as a result of a translocation of the c-abl gene from chromosome 9 to downstream of the bcr gene on chromosome 22 (ph').
K S, Nadkarni, R H, Datar, S G, Rao
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1996
Antisense RNAs are small, diffusible, untranslated RNAs that pair to complementary regions on specific target RNAs, altering the expression or function of those RNAs post-transcriptionally. Antisense RNA control is well documented in bacteria, especially in their accessory elements—plasmids, bacteriophages and transposable elements (see Table 5.1).
Brian N. Zeiler, Robert W. Simons
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Antisense RNAs are small, diffusible, untranslated RNAs that pair to complementary regions on specific target RNAs, altering the expression or function of those RNAs post-transcriptionally. Antisense RNA control is well documented in bacteria, especially in their accessory elements—plasmids, bacteriophages and transposable elements (see Table 5.1).
Brian N. Zeiler, Robert W. Simons
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Antisense RNA Elements for Downregulating Expression
2019Antisense RNA (asRNA) technology is an important tool for downregulating gene expression. When applying this strategy, the asRNA interference efficiency is determined by several elements including scaffold design, loop size, and relative abundance. Here, we take the Escherichia coli gene fabD encoding malonyl-CoA-[acyl-carrier-protein] transacylase as ...
Yaping, Yang +3 more
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