Results 61 to 70 of about 61,173 (287)

Revision of the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) diagnostic criteria using antithrombin activity

Critical Care, 2016
BackgroundWith advances in the treatment of sepsis, the systemic inflammatory response syndrome (SIRS) has been losing its prognostic power. Since the SIRS category is no longer used for the diagnosis of sepsis, the disseminated intravascular coagulation
T. Iba, M. Di Nisio, J. Thachil, H. Wada, H. Asakura, Koichi Sato, Naoya Kitamura, D. Saitoh   +7 more
semanticscholar   +1 more source

Influence of patient factors on target plasma volume treated attainment rate during double filtration plasmapheresis in patients with hypertriglyceridemic acute pancreatitis

Therapeutic Apheresis and Dialysis, EarlyView.
Abstract Introduction This study aims to investigate patient factors affecting the rate of plasma volume target attained in hypertriglyceridemic pancreatitis (HTG‐AP) patients undergoing double filtration plasmapheresis (DFPP). Methods A retrospective analysis of 82 HTG‐AP‐interpreted patients from January 2019 to April 2024 compared target plasma ...
Hui Zhang, Chenqiang Zhu, Yunlong Wu
wiley   +1 more source

New Insights in Thrombin Inhibition Structure–Activity Relationships by Characterization of Octadecasaccharides from Low Molecular Weight Heparin

Molecules, 2017
Low Molecular Weight Heparins (LMWH) are complex anticoagulant drugs that mainly inhibit the blood coagulation cascade through indirect interaction with antithrombin.
Pierre A. J. Mourier, Olivier Y. Guichard, Fréderic Herman, Philippe Sizun, Christian Viskov   +4 more
doaj   +1 more source

Influence of high‐dose antithrombin on platelet function and blood coagulation

Acute Medicine & Surgery, 2021
Aim In healthy adults, there are sufficient amounts of antithrombin in the blood to regulate thrombin. However, the effects of high concentrations of antithrombin on dose‐dependent anticoagulation and platelet function have not been reported.
Toru Miike, Yuichiro Sakamoto, Shougo Narumi, Kunimasa Yoshitake, Ryota Sakurai, Kento Nakayama, Satoshi Inoue   +6 more
doaj   +1 more source

Rebalancing Hemostasis: Fitusiran as a First-in-Class RNAi Therapy in Hemophilia A and B. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Fitusiran is a first‐in‐class RNA interference (RNAi) therapy that lowers antithrombin (AT) to rebalance hemostasis in people with Hemophilia A or B, with or without inhibitors. Its recent FDA approval marks a major shift toward factor‐independent prophylaxis.
Rehman RU, Fatima R, Akilimali A.
europepmc   +2 more sources

Bleeding Disorders in Children With Genetic Diseases: A Narrative Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim The lack of data on bleeding risk assessment in children with genetic diseases is concerning given their increased care needs and risk of haemorrhagic complications compared to the general population. Identification of haemostatic disorders is crucial for implementing preventive measures and mitigating bleeding risk.
Raphaelle Cagol, Mariam Sbeity Barakat, Marjolaine Willems, Tasnime Akbaraly, Biron‐Andreani Christine, Isabelle Diaz, Alexandre Theron   +6 more
wiley   +1 more source

Multiple venous thromboembolisms in a pregnant patient carrying a novel mutation in SERPINC1 (p.M313T) that causes a transient antithrombin deficiency: a case report

Thrombosis Journal, 2023
Background Congenital antithrombin deficiency is an autosomal dominant disease that results in deep venous thrombosis and pulmonary embolism, which is mainly caused by mutations in the antithrombin gene (SERPINC1). Since SERPINC1 is highly susceptible to
Yuwen Huang, Yinling Wang, Xiaoli Wang, Jue Liu, Bing Luo, Yuanmei Gao   +5 more
doaj   +1 more source

Coexistence of antithrombin deficiency and suspected inferior vena cava atresia in an adolescent and his mother – case report and clinical implications [PDF]

, 2021
Merle Müller-Knapp, Carl-Friedrich Classen, Ralf Knöfler, Christian Spang, Christina Hauenstein, T. Heinrich, Fatine Gabriel, Jan Däbritz, Daniel A. Reuter, Johannes Ehler   +9 more
openalex   +1 more source

Successful use of haemoperfusion therapy in an adult horse with hepatic encephalopathy and cholangiohepatitis

Equine Veterinary Education, EarlyView.
Summary A 4‐year‐old, 520 kg, American Quarter Horse broodmare, approximately 90 days in foal, was presented to Texas A&M University Teaching Hospital for suspected liver disease. Based on clinicopathological values and hepatic abnormalities noted ultrasonographically, the mare was presumptively diagnosed with cholangiohepatitis.
A. C. Trimble, S. H. White‐Springer, S. Alpini, E. Rumfola, A. N. DiSilvestro, Y. Ueda, K. Hobbs   +6 more
wiley   +1 more source

Natural anticoagulant protein levels in patients with transfusion-dependent thalassemia in Nineveh province

Iraqi Journal of Hematology
BACKGROUND: Protein C (PC), protein S (PS), and antithrombin levels dramatically reduced in thalassemic patients, particularly those with splenectomies and few transfusions, indicating a significant involvement in hypercoagulability.
Samar Saleh Saadi
doaj   +1 more source