Results 11 to 20 of about 1,481 (212)

Kinetic evidence that allosteric activation of antithrombin by heparin is mediated by two sequential conformational changes [PDF]

, 2010
The serpin, antithrombin, requires allosteric activation by a sequencespecific pentasaccharide unit of heparin or heparan sulfate glycosaminoglycans to function as an anticoagulant regulator of blood clotting proteases.
Benjamin Richard (7931342), Steven T. Olson (7930775), Sophia Schedin-Weiss (189313)   +2 more
core   +7 more sources

Insight into Residues Critical for Antithrombin Function from an Expanded Database of Sequences That Includes Frog, Turtle and Ostrich Antithrombins [PDF]

The Scientific World Journal, 2002
Marija Backovic, Peter G.W. Gettins
doaj   +3 more sources

A test for antithrombin in the blood [PDF]

Experimental Biology and Medicine, 1914
A test is described for the estimation of antithrombin in the blood. The chief advantage of the test is that it is simple, and does not require the preparation of fibrinogen and of thrombin, which are difficult to prepare and to maintain in a pure state.
openaire   +2 more sources

Use of Antithrombin and Thrombomodulin in the Management of Disseminated Intravascular Coagulation in Patients with Acute Cholangitis

Gut and Liver, 2013
Background/AimsTo evaluate the usefulness and safety of treating disseminated intravascular coagulation (DIC) complicating cholangitis primarily with antithrombin (AT) and thrombomodulin (rTM).Methods : A DIC treatment algorithm was determined on the ...
doaj   +1 more source

Insight into Residues Critical for Antithrombin Function from Analysis of an Expanded Database of Sequences That Includes Frog, Turtle, and Ostrich Antithrombins

, 2016
Complete sequences were determined for frog, turtle, and ostrich antithrombins. Protein sequence comparisons with the other 10 known antithrombin sequences and with sequences of other serpins have provided striking evidence for the conservation of the ...
Peter G. W. Gettins (3087792), Marija Backovic (3087789)   +1 more
core   +1 more source

O novo modelo da cascata de coagulação baseado nas superfícies celulares e suas implicações A cell-based model of coagulation and its implications

Revista Brasileira de Hematologia e Hemoterapia, 2010
O conceito da cascata da coagulação descreve as interações bioquímicas dos fatores da coagulação, entretanto, tem falhado como um modelo do processo hemostático in vivo. A hemostasia requer a formação de um tampão de plaquetas e fibrina no local da lesão
Cláudia Natália Ferreira, Marinez de Oliveira Sousa, Luci Maria Sant'Ana Dusse, Maria das Graças Carvalho   +3 more
doaj   +1 more source

Efficacy and safety of direct oral anticoagulants compared with warfarin in antiphospholipid syndrome. Results of a multicenter retrospective cohort study

Research and Practice in Thrombosis and Haemostasis
Background: Direct oral anticoagulants (DOACs) have become firstline treatment for many thrombotic conditions, but their use in antiphospholipid syndrome (APS) patients remains controversial.
Maha A.T. Elsebaie, Zoe Wickham, Stephanie DeBragga, Stacey Fedewa, Mohamed Amgad, Jane Jungyoon Park, Allen Li, Ali Eshaghpour, Juan Li, Mark Crowther, Manila Gaddh   +10 more
doaj   +1 more source

Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells

, 2010
[[abstract]]Antithrombin, a key serpin family regulator of blood coagulation proteases, is transformed into a potent antiangiogenic factor by limited proteolysis or mild heating.
Zhang, WQ;Chuang, YJ;Swanson, R;Li, J;Seo, KG;Leung, L;Lau, LF;Olson, ST
core   +1 more source

In Vivo Monitoring of Thrombo‐Inflammatory Biomarkers via Molecularly Imprinted Polymer‐Integrated Hydrogel Microneedles

Advanced Materials, EarlyView.
A wearable electrochemical microneedle patch integrates Prussian Blue redox transduction with molecularly imprinted polymer recognition for reagent‐free sampling and detection of thrombo‐inflammatory biomarkers in dermal interstitial fluid. The platform tracks thrombin and inflammatory cytokines with sensitive in vitro, ex vivo, and in vivo performance,
Mahmoud Ayman Saleh, Peyman GhavamiNejad, Arash Khorrami Jahromi, Sanjana Srikant, Sripadh Guptha Yedire, Fatemeh Keyvani, Roozbeh Siavash Moakhar, Sajad Shiekh, Mackenzie Graham, Joe Quadrilatero, Mahla Poudineh, Sara Mahshid   +11 more
wiley   +1 more source

Changes in the use of vitamin K antagonists and direct oral anticoagulants and impact on the incidence of oral anticoagulation-related intracerebral hemorrhage: population-wide prescription patterns in two 5-year cohorts

Annals of Medicine
Background We investigated population-wide changes in prescriptions of oral anticoagulants (OAC) (vitamin K antagonists [VKA]) compared to direct oral anticoagulants (DOAC) and whether these translated into a decline in incidences of OAC-related ...
Liisa Tomppo, Hanne Sallinen, Otto Lankinen, Giannis Mastoras, Georgios Georgiopoulos, Sven Poli, Jukka Putaala, Daniel Strbian   +7 more
doaj   +1 more source