Insight into Residues Critical for Antithrombin Function from an Expanded Database of Sequences That Includes Frog, Turtle and Ostrich Antithrombins [PDF]
The Scientific World Journal, 2002 Marija Backovic, Peter G.W. Gettins
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Insight into Residues Critical for Antithrombin Function from Analysis of an Expanded Database of Sequences That Includes Frog, Turtle, and Ostrich Antithrombins [PDF]
, 2016 Complete sequences were determined for frog, turtle, and ostrich antithrombins. Protein sequence comparisons with the other 10 known antithrombin sequences and with sequences of other serpins have provided striking evidence for the conservation of the ...
Peter G. W. Gettins (3087792) +1 more
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Thrombin-Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis [PDF]
, 2021 Fibrinogen is a well-known risk factor for arterial and venous thrombosis. Its function is not restricted to clot formation, however, as it partakes in a complex interplay between thrombin, soluble plasma fibrinogen, and deposited fibrin matrices ...
Hemker, H Coenraad +9 more
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Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells [PDF]
, 2010 [[abstract]]Antithrombin, a key serpin family regulator of blood coagulation proteases, is transformed into a potent antiangiogenic factor by limited proteolysis or mild heating.
Zhang, WQ;Chuang, YJ;Swanson, R;Li, J;Seo, KG;Leung, L;Lau, LF;Olson, ST
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Kinetic evidence that allosteric activation of antithrombin by heparin is mediated by two sequential conformational changes [PDF]
, 2010 The serpin, antithrombin, requires allosteric activation by a sequencespecific pentasaccharide unit of heparin or heparan sulfate glycosaminoglycans to function as an anticoagulant regulator of blood clotting proteases.
Sophia Schedin-Weiss +8 more
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Revista Brasileira de Hematologia e Hemoterapia, 2010 O conceito da cascata da coagulação descreve as interações bioquímicas dos fatores da coagulação, entretanto, tem falhado como um modelo do processo hemostático in vivo. A hemostasia requer a formação de um tampão de plaquetas e fibrina no local da lesão
Cláudia Natália Ferreira +3 more
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Model for the interplay of neural activity and Schwann cells in maintaining the motor innervation of the NMJ. [PDF]
, 2019 (A) Summary of the presence or absence of Schwann cells, neuromuscular activity (+,–), or developmental synaptic degeneration in 19 mouse lines. erbB2-/- mice refer to erbB2 null mutants crossed to transgenic mice overexpressing erbB2 in the heart, which
Kuo-Fen Lee (436236) +10 more
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Gut and Liver, 2013 Background/AimsTo evaluate the usefulness and safety of treating disseminated intravascular coagulation (DIC) complicating cholangitis primarily with antithrombin (AT) and thrombomodulin (rTM).Methods : A DIC treatment algorithm was determined on the ...
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Aligned sequences of BjATl and 10 vertebrate antithrombins. [PDF]
, 2012 Mature human antithrombin numbering is used. Secondary structural elements of BjATl predicted based on the structure of human antithrombin are shown above the sequences.
Yeqing Chao (177970) +4 more
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Prevention of venous thromboembolism in gynecological cancer patients undergoing major abdominopelvic surgery: A systematic review and network meta-analysis [PDF]
, 2021 OBJECTIVE: Although thromboprophylaxis is recommended to reduce death and disability from venous thromboembolism (VTE), it remains underused due to a perceived risk of bleeding, especially in major abdominopelvic surgical patients.METHODS: We conducted a
Charakorn, Chuenkamon +6 more
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