Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]
, 1990 The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Ahnert-Hilger, G. +4 more
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Expression, Purification, and Functional Analysis of Novel RelE Operon from X. nematophila
The Scientific World Journal, 2014 Bacterial toxin-antitoxin (TA) complexes induce programmed cell death and also function to relieve cell from stress by various response mechanisms. Escherichia coli RelB-RelE TA complex consists of a RelE toxin functionally counteracted by RelB antitoxin.
Jitendra Singh Rathore +1 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2020 Botulinum neurotoxins (BoNTs) are among the most toxic proteins. Vaccination is an effective strategy to prevent botulism. To generate a vaccine suitable for human use, a recombinant non-His-tagged isoform of the Hc domain of botulinum neurotoxin ...
Dan-Yang Shi +9 more
doaj +1 more source
Molecular processes underlying synergistic linuron mineralization in a triple-species bacterial consortium biofilm revealed by differential transcriptomics [PDF]
, 2018 The proteobacteria Variovorax sp. WDL1, Comamonas testosteroni WDL7, and Hyphomicrobium sulfonivorans WDL6 compose a triple-species consortium that synergistically degrades and grows on the phenylurea herbicide linuron.
Anders +52 more
core +2 more sources
Biotechnological Trends in Spider and Scorpion Antivenom Development
Toxins, 2016 Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain.
Andreas Hougaard Laustsen +5 more
doaj +1 more source
Molecular Characterization of Protease Activity in Serratia sp. Strain SCBI and Its Importance in Cytotoxicity and Virulence [PDF]
, 2014 A newly recognized Serratia species, termed South African Caenorhabditis briggsae isolate (SCBI), is both a mutualist of the nematode Caenorhabditis briggsae KT0001 and a pathogen of lepidopteran insects. Serratia sp.
Petersen, Lauren M., Tisa, Louis S.
core +2 more sources
Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins. [PDF]
, 2019 Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high potency and lethality.
Cobb, Ronald R +12 more
core
Clinical Recovery and Circulating Botulinum Toxin Type F in Adult Patient
Emerging Infectious Diseases, 2009 A 56-year-old woman in Helena, Montana, USA, who showed clinical signs of paralysis, received antitoxins to botulinum toxins A, B, and E within 24 hours; nevertheless, symptoms progressed to complete quadriplegia. On day 8, she began moving spontaneously,
Jeremy Sobel +5 more
doaj +1 more source
Shaping Pulses to Control Bistable Biological Systems [PDF]
, 2015 In this paper we study how to shape temporal pulses to switch a bistable system between its stable steady states. Our motivation for pulse-based control comes from applications in synthetic biology, where it is generally difficult to implement real-time ...
Angeli, David +3 more
core +2 more sources
Detoxification of Peptide-Containing Biotoxins
Вестник войск РХБ защитыHighlights. Peptide biotoxins are important problem for human health and as lethal agents due to their wild diversity of chemical structures and biological sources.Such peptide biotoxins and prion proteins can be effectively neutralized by different ...
Ilya V. Lyagin +4 more
doaj +1 more source