Results 91 to 100 of about 59,908 (306)

Type II toxin–antitoxin system in bacteria: activation, function, and mode of action

Biophysics Reports, 2020
The toxin–antitoxin (TA) system is composed of a stable toxin and an unstable antitoxin that neutralizes the toxin. Being perhaps the most studied among the different TA types, type II TA systems are widely distributed and often exist in multiple copies ...
Siping Zhang, Qian Wang, S. Quan, Xiao-Quan Yu, Yong Wang, Ding-Ding Guo, Liang Peng, Hu-Yuan Feng, Yongxing He   +8 more
semanticscholar   +1 more source

Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras, Mireia Rosell, Miguel Romero‐Durana, Víctor Monteagudo, Fabian Glaser, Juan Fernandez‐Recio   +5 more
wiley   +1 more source

Role of Homologous Fc Fragment in the Potency and Efficacy of Anti‐Botulinum Antibody Preparations

Toxins, 2017
The only approved treatment for botulism relies on passive immunity which is mostly based on antibody preparations collected from hyper‐immune horses. The IgG Fc fragment is commonly removed from these heterologous preparations to reduce the incidence of
Amram Torgeman, Eyal Ozeri, Alon Ben David, Eran Diamant, Osnat Rosen, Arieh Schwartz, Ada Barnea, Arik Makovitzki, Avishai Mimran, Ran Zichel   +9 more
doaj   +1 more source

What traits are carried on mobile genetic elements, and why? [PDF]

, 2010
Although similar to any other organism, prokaryotes can transfer genes vertically from mother cell to daughter cell, they can also exchange certain genes horizontally.
A Gardner, A Gardner, A Gardner, A Gardner, A Gardner, A Gardner, A Mochizuki, A Norman, A Philppon, A Wagner, AD O’Brien, AS Griffin, B Sanchez, BJ Crespi, BK Kozlowicz, BMM Ahmer, BR Levin, C Buchrieser, CE White, CF Amabile-Cuevas, CG Kurland, CM Thomas, CM Yates, CT Bergstrom, D Gevers, D J Rankin, DJ Rankin, DM Livermore, E Cascales, E Cascales, E Lerat, E P C Rocha, E Polzleitner, ES Egan, F Bushman, F de la Cruz, F Delsuc, F Dionisio, F Dionisio, F Harrison, F Rousset, FM Stewart, FR Slater, G Gil, G Hardin, GA Dykes, H Knothe, H Ochman, I Chen, I Kobayashi, I Rasched, J Hacker, J Lederberg, J Paulsson, J Smith, J Zupan, JB Ferdy, JB Xavier, JC Diaz Ricci, JE Bouma, JL Martinez, JL Martínez, JL Sachs, JL Sachs, JR van der Ploeg, K Lee, KM Oliver, KR Foster, KR Foster, KR Foster, L Buts, L Chao, L Keller, L Lehmann, L Lehmann, L Riboli-Sasco, L Van Melderen, LE Orgel, LJ Johnson, LN Lili, LS Frost, M Achtman, M Ackermann, M Touchon, MA Riley, MI Bahl, MI Bahl, MK Waldor, MP Nuti, N Goldenfeld, ND Zinder, PB Rainey, PE Turner, PE Turner, R Barrangou, R Korona, RD Magnuson, RE Fox, RJ Ellis, RJF Haft, RM Anderson, RM Anderson, RM May, S Alizon, S P Brown, SA West, SA West, SA West, SA West, SC Slater, SJ Sorensen, SM Faruque, SP Brown, SP Brown, SP Brown, SP Brown, SR Bordenstein, T Nogueira, TF Cooper, TF Cooper, VL Arcus, WD Hamilton, WD Hamilton, WG Eberhard   +123 more
core   +2 more sources

Characterization of a toxin-antitoxin system in Mycobacterium tuberculosis suggests neutralization by phosphorylation as the antitoxicity mechanism

Communications Biology, 2020
Mycobacterium tuberculosis (Mtb) encodes an exceptionally large number of toxin-antitoxin (TA) systems, supporting the hypothesis that TA systems are involved in pathogenesis.
Xia Yu, Xiaopan Gao, K. Zhu, Han Yin, Xu-Jian Mao, J. Wojdyla, B. Qin, Hairong Huang, Meitian Wang, Yi-Cheng Sun, S. Cui   +10 more
semanticscholar   +1 more source

PEARL: Protein Eluting Alginate with Recombinant Lactobacilli

Small, EarlyView.
Probiotic lactobacilli meet engineered living materials: This study introduces PEARL (protein eluting alginate with recombinant lactobacilli), an innovative engineered living material combining Lactiplantibacillus plantarum and alginate beads for controlled protein release.
Varun Sai Tadimarri, Marc Blanch‐Asensio, Ketaki Deshpande, Jonas Baumann, Carole Baumann, Rolf Müller, Sara Trujillo, Shrikrishnan Sankaran   +7 more
wiley   +1 more source

Long-Term Pulmonary Damage in Surviving Antitoxin-Treated Mice following a Lethal Ricin Intoxication

Toxins
Ricin, a highly potent plant-derived toxin, is considered a potential bioterrorism weapon due to its pronounced toxicity, high availability, and ease of preparation.
Yoav Gal, Anita Sapoznikov, Shlomi Lazar, David Shoseyov, Moshe Aftalion, Hila Gutman, Yentl Evgy, Rellie Gez, Reinat Nevo, Reut Falach   +9 more
doaj   +1 more source

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function

Toxins, 2020
Botulinum neurotoxin (BoNT) serotype E is one of three serotypes that cause the preponderance of human botulism cases and is a Tier 1 Select Agent. BoNT/E is unusual among BoNT serotypes for its rapid onset and short duration of intoxication.
Jacqueline M. Tremblay, Edwin Vazquez-Cintron, Kwok-Ho Lam, Jean Mukherjee, Daniela Bedenice, Celinia A. Ondeck, Matthieu T. Conroy, Skylar M. L. Bodt, Brittany M. Winner, Robert P. Webb, Konstantin Ichtchenko, Rongsheng Jin, Patrick M. McNutt, Charles B. Shoemaker   +13 more
doaj   +1 more source

Shaping Pulses to Control Bistable Biological Systems [PDF]

, 2015
In this paper we study how to shape temporal pulses to switch a bistable system between its stable steady states. Our motivation for pulse-based control comes from applications in synthetic biology, where it is generally difficult to implement real-time ...
Angeli, David, Oyarzun, Diego, Sootla, Aivar, Stan, Guy-Bart   +3 more
core   +2 more sources

Antimicrobial prescribing guidelines for horses in Australia

Australian Veterinary Journal, EarlyView.
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt, K Thomas, S Page, J Norris, G Browning, C El Hage, A Stewart, J Gilkerson, G Muscatello, D Verwilghen, G van Galen, J Bauquier, R Cuming, B Reynolds, C Whittaker, E Wilkes, J Clulow, C Burden, L Begg   +18 more
wiley   +1 more source