Results 31 to 40 of about 48,883 (257)

Evaluating the Potential for Cross-Interactions of Antitoxins in Type II TA Systems

Toxins, 2020
The diversity of Type-II toxin–antitoxin (TA) systems in bacterial genomes requires tightly controlled interaction specificity to ensure protection of the cell, and potentially to limit cross-talk between toxin–antitoxin pairs of the same family of TA ...
Chih-Han Tu, Michelle Holt, Shengfeng Ruan, Christina Bourne   +3 more
doaj   +1 more source

Shaping Pulses to Control Bistable Monotone Systems Using Koopman Operator [PDF]

, 2016
In this paper, we further develop a recently proposed control method to switch a bistable system between its steady states using temporal pulses. The motivation for using pulses comes from biomedical and biological applications (e.g.
Goncalves, Jorge, Mauroy, Alexandre, Sootla, Aivar   +2 more
core   +2 more sources

A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A

Toxins, 2018
The standard of treatment for botulism, equine antitoxin, is a foreign protein with associated safety issues and a short serum half-life which excludes its use as a prophylactic antitoxin and makes it a less-than-optimal therapeutic.
Jianlong Lou, Weihua Wen, Fraser Conrad, Qi Meng, Jianbo Dong, Zhengda Sun, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, Luisa W. Cheng, Thomas D. Henderson, Jennifer L. Brown, Theresa J. Smith, Leonard A. Smith, Anthony Cormier, James D. Marks   +14 more
doaj   +1 more source

Role of Homologous Fc Fragment in the Potency and Efficacy of Anti‐Botulinum Antibody Preparations

Toxins, 2017
The only approved treatment for botulism relies on passive immunity which is mostly based on antibody preparations collected from hyper‐immune horses. The IgG Fc fragment is commonly removed from these heterologous preparations to reduce the incidence of
Amram Torgeman, Eyal Ozeri, Alon Ben David, Eran Diamant, Osnat Rosen, Arieh Schwartz, Ada Barnea, Arik Makovitzki, Avishai Mimran, Ran Zichel   +9 more
doaj   +1 more source

Suppressing Alpha-Hemolysin as Potential Target to Screen of Flavonoids to Combat Bacterial Coinfection

Molecules, 2021
The rapid emergence of bacterial coinfection caused by cytosolic bacteria has become a huge threat to public health worldwide. Past efforts have been devoted to discover the broad-spectrum antibiotics, while the emergence of antibiotic resistance ...
Shangwen He, Qian Deng, Bingbing Liang, Feike Yu, Xiaohan Yu, Dawei Guo, Xiaoye Liu, Hong Dong   +7 more
doaj   +1 more source

MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding

Nature Communications, 2023
Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M.
Xibing Xu, Ben Usher, Claude Gutierrez, Roland Barriot, Tom J. Arrowsmith, Xue Han, Peter Redder, Olivier Neyrolles, Tim R. Blower, Pierre Genevaux   +9 more
doaj   +1 more source

The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii [PDF]

, 2014
Although analysis of toxin-antitoxin (TA) systems can be instructive, to date, there is no information on the prevalence and identity of TA systems based on a large panel of Acinetobacter baumannii clinical isolates.
Ghafourian, S, Good, L, Hamat, R A, Neela, V, Sadeghifard, N, Sekawi, Z, Soheili, S   +6 more
core   +5 more sources

Diverse genetic contexts of HicA toxin domains propose a role in anti-phage defense

mBio
Toxin–antitoxin (TA) modules are prevalent in prokaryotic genomes, often in substantial numbers. For instance, the Mycobacterium tuberculosis genome alone harbors close to 100 TA modules, half of which belong to a singular type.
Kenn Gerdes
doaj   +1 more source

Geometric Properties of Isostables and Basins of Attraction of Monotone Systems [PDF]

, 2017
In this paper, we study geometric properties of basins of attraction of monotone systems. Our results are based on a combination of monotone systems theory and spectral operator theory.
Mauroy, Alexandre, Sootla, Aivar
core   +3 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source