Results 31 to 40 of about 59,908 (306)

Conjugative plasmid-encoded toxin–antitoxin system PrpT/PrpA directly controls plasmid copy number

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Since conjugative plasmids are usually large and may carry genes encoding functions that are detrimental to the bacterial host, minimizing plasmid copy number is critical for reducing the host burden.
S. Ni, Baiyuan Li, Kaihao Tang, Jianyun Yao, T. Wood, Pengxia Wang, Xiaoxue Wang   +6 more
semanticscholar   +1 more source

An Auto-Regulating Type II Toxin-Antitoxin System Modulates Drug Resistance and Virulence in Streptococcus suis

Frontiers in Microbiology, 2021
Toxin-antitoxin (TA) systems are ubiquitous genetic elements that play an essential role in multidrug tolerance and virulence of bacteria. So far, little is known about the TA systems in Streptococcus suis.
Qibing Gu, Qibing Gu, Qibing Gu, Peijuan He, Peijuan He, Peijuan He, Dan Wang, Dan Wang, Dan Wang, Jiale Ma, Jiale Ma, Jiale Ma, Xiaojun Zhong, Xiaojun Zhong, Xiaojun Zhong, Xiaojun Zhong, Yinchu Zhu, Yinchu Zhu, Yinchu Zhu, Yinchu Zhu, Yue Zhang, Yue Zhang, Yue Zhang, Yue Zhang, Qiankun Bai, Qiankun Bai, Qiankun Bai, Zihao Pan, Zihao Pan, Zihao Pan, Huochun Yao, Huochun Yao, Huochun Yao   +32 more
doaj   +1 more source

YoeB toxin is activated during thermal stress. [PDF]

, 2015
Type II toxin-antitoxin (TA) modules are thought to mediate stress-responses by temporarily suppressing protein synthesis while cells redirect transcription to adapt to environmental change.
Garza-Sánchez, Fernando, Hayes, Christopher S, Janssen, Brian D   +2 more
core   +1 more source

The role of small proteins in Burkholderia cenocepacia J2315 biofilm formation, persistence and intracellular growth [PDF]

, 2019
Burkholderia cenocepacia infections are difficult to treat due to resistance, biofilm formation and persistence. B. cenocepacia strain J2315 has a large multi-replicon genome (8.06 Mb) and the function of a large fraction of (conserved) hypothetical ...
Braeckmans, Kevin, Coenye, Tom, Crabbé, Aurélie, Daled, Simon, De Keersmaecker, Herlinde, Deforce, Dieter, Dhaenens, Maarten, Jurėnas, Dukas, Ostyn, Lisa, Sass, Andrea, Teirlinck, Eline, Van Acker, Heleen, Van Melderen, Laurence   +12 more
core   +1 more source

THE COST OF ANTITOXIN. [PDF]

The Lancet, 1906
n ...
openaire   +2 more sources

Reassessing the Role of the Type II MqsRA Toxin-Antitoxin System in Stress Response and Biofilm Formation: mqsA Is Transcriptionally Uncoupled from mqsR

mBio, 2019
Toxin-antitoxin (TA) systems are broadly distributed modules whose biological roles remain mostly unknown. The mqsRA system is a noncanonical TA system in which the toxin and antitoxins genes are organized in operon but with the particularity that the ...
Nathan Fraikin, Clothilde J. Rousseau, Nathalie Goeders, Laurence Van Melderen   +3 more
doaj   +1 more source

Rapid Identification of Secondary Structure and Binding Site Residues in an Intrinsically Disordered Protein Segment

Frontiers in Genetics, 2021
Mycobacterium tuberculosis harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in M. tuberculosis persistence and disease.
Soumyanetra Chandra, Gopinath Chattopadhyay, Raghavan Varadarajan   +2 more
doaj   +1 more source

A case of asymmetric cranial nerve palsy due to iatrogenic botulism [PDF]

Asia Pacific Journal of Medical Toxicology, 2021
Introduction:Botulism is a rare but lethal disease and atypical clinical presentations of this disease are difficult to diagnose. We report a case of iatrogenic botulism who presented withasymmetric cranial nerve involvement.Case report:An eighteen year ...
Muhammad Akbar Baig, Joshua Nogar
doaj   +1 more source

Studies on the denaturation of antibody: II. The effect of protein concentration on the rate of denaturation of diphtheria antitoxin by urea [PDF]

, 1945
The specific rate of inactivation of antitoxin in urea solutions, as measured by the Römer neutralization test with toxin, has been shown to be independent of the concentration of protein under the conditions studied.
Wright, George G.
core   +1 more source

Prokaryote toxin–antitoxin modules: Complex regulation of an unclear function

Protein Science, 2021
Toxin–antitoxin (TA) modules are small operons in bacteria and archaea that encode a metabolic inhibitor (toxin) and a matching regulatory protein (antitoxin).
P. D. Bruyn, Y. Girardin, R. Loris
semanticscholar   +1 more source