Results 21 to 30 of about 25,421 (180)
Toxins, 2020 Botulinum neurotoxin serotype E (BoNT/E) is one of the major causes of human botulism, which is a life-threatening disease caused by flaccid paralysis of muscles. After receptor-mediated toxin internalization into motor neurons, the translocation domain (
Kwok-Ho Lam +3 more
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An oxygen-sensitive toxin–antitoxin system
Nature Communications, 2016 Classical toxin–antitoxin systems in bacteria are based on silencing of a toxin by an antitoxin that, when inactivated, releases the toxin, resulting in a change in metabolism. Here, the authors characterize an oxygen-sensitive toxin–antitoxin system and
Oriol Marimon +13 more
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Postbooster Antibodies from Humans as Source of Diphtheria Antitoxin
Emerging Infectious Diseases, 2016 Diphtheria antitoxin for therapeutic use is in limited supply. A potential source might be affinity-purified antibodies originally derived from plasma of adults who received a booster dose of a vaccine containing diphtheria toxoid. These antibodies might
Jesús F. Bermejo-Martin +5 more
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JAMA: The Journal of the American Medical Association, 1899 In a lecture delivered by Dr. T. Clifford Allbutt, regius professor of physics in Cambridge University, England, before the Johns Hopkins University in October, 1898, occur these words 1 : "The study of origins, then, is not only the new method of modern criticism, of modern history, of modern anthropology, of our reading of the evolution of the ...
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Chaperone addiction of toxin–antitoxin systems
Nature Communications, 2016 Some bacterial toxin-antitoxin systems consist of a labile antitoxin that inhibits a toxin, and a chaperone that stabilizes the antitoxin. Here, Bordes et al.
Patricia Bordes +8 more
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Antibodies and Vaccines against Botulinum Toxins: Available Measures and Novel Approaches
Toxins, 2019 Botulinum neurotoxin (BoNT) is produced by the anaerobic, Gram-positive bacterium Clostridium botulinum. As one of the most poisonous toxins known and a potential bioterrosism agent, BoNT is characterized by a complex mode of action comprising ...
Christine Rasetti-Escargueil +1 more
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Toxins, 2018 Ricin, a highly lethal toxin derived from the seeds of Ricinus communis (castor beans) is considered a potential biological threat agent due to its high availability, ease of production, and to the lack of any approved medical countermeasure against ...
Reut Falach +11 more
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