Results 21 to 30 of about 32,139 (221)

Medical Countermeasures against Ricin Intoxication

Toxins, 2023
Ricin toxin is a disulfide-linked glycoprotein (AB toxin) comprising one enzymatic A chain (RTA) and one cell-binding B chain (RTB) contained in the castor bean, a Ricinus species.
Christine Rasetti-Escargueil, Arnaud Avril   +1 more
doaj   +1 more source

ANTITOXIN [PDF]

The American Journal of the Medical Sciences, 1896
n ...
openaire   +3 more sources

Purification and characterization of alkaline soda-bleach stable protease from Bacillus sp. APP-07 isolated from Laundromat soil

Journal of Genetic Engineering and Biotechnology, 2018
The detergent-compatible alkaline protease was produced from the bacterial strain Bacillus sp. APP-07 isolated from Laundromat soil of Solapur, Maharashtra, India.
I.K. Shaikh, P.P. Dixit, T.M. Shaikh
doaj   +1 more source

The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict [PDF]

, 2012
Bacterial genomes commonly contain 'addiction' gene complexes that code for both a toxin and a corresponding antitoxin. As long as both genes are expressed, cells carrying the complex can remain healthy.
Rankin, Daniel J., Leighton A. Turner, Daniel J. Rankin, Heinemann, Jack A., Brown, Sam P., Sam P. Brown, Turner, Leighton A., Jack A. Heinemann   +7 more
core   +1 more source

Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin [PDF]

, 2016
FIC domain proteins mediate post-translational modifications of target proteins, which typically results in their inactivation. Depending on the conservation of crucial active site residues, the FIC fold serves as structural scaffold for various ...
Stanger, Frédéric V., Frédéric V Stanger, Tilman Schirmer, Alexander Harms (3132942), Dehio, Christoph, Harms, Alexander, Schirmer, Tilman, Christoph Dehio, Frédéric V. Stanger (585551), Alexander Harms, Tilman Schirmer (585552), Christoph Dehio (200951)   +11 more
core   +2 more sources

VapC Toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins [PDF]

, 2011
The chromosome of Mycobacterium tuberculosis (Mtb) encodes forty seven toxin-antitoxin modules belonging to the VapBC family. The role of these modules in the physiology of Mtb and the function(s) served by their expansion are unknown.
Mizrahi, Valerie, Bhavna G Gordhan, Vickery Arcus, Diane Kuhnert, Valerie Mizrahi, Ahidjo, Bintou Ahmadou, Kuhnert, Diane, Edith E Machowski, Machowski E.E., Joanna L. Mckenzie, Garth L. Abrahams, Kuhnert D., Machowski Edith E., Abrahams, Garth L., Ahidjo B.A., Bintou Ahmadou Ahidjo, Gordhan, Bhavna G., Arcus V., Garth L Abrahams, Abrahams G.L., Machowski, Edith E., Mizrahi V., Kuhnert Diane, Ahidjo Bintou Ahmadou, McKenzie Joanna L., Arcus Vickery, Mizrahi Valerie, Edith E. Machowski, Abrahams Garth L., Gordhan B.G., McKenzie J.L., Gordhan Bhavna G., Bhavna G, Arcus, Vickery L., Bhavna G. Gordhan, McKenzie, Joanna Leigh, Joanna L McKenzie   +36 more
core   +2 more sources

Human versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2 × 2 factorial randomised controlled trial [PDF]

, 2022
Background Intramuscular antitoxin is recommended in tetanus treatment, but there are few data comparing human and equine preparations. Tetanus toxin acts within the CNS, where there is limited penetration of peripherally administered antitoxin; thus ...
Tuyen, Pham Thi, Day, Nicholas Pj, Turner, Hugo C, Nguyen, Nguyen Thanh, Tan Thanh, Tran, Yen, Lam Minh, Hong, Duc Du, Thuy, Duong Bich, Thuy, Tran Thi Diem, Phong, Nguyen Thanh, Duong, Ha Thi Hai, Wyncoll, Duncan, Nhat, Phung Tran Huy, Thwaites, C Louise, Van Tan, Le, Thwaites, Guy E, Lieu, Pham Thi, Khanh, Phan Nguyen Quoc, Geskus, Ronald B, Hanh, Bui Thi Bich, Tho, Phan Vinh, Loan, Huynh Thi, Van Vinh Chau, Nguyen, Kestelyn, Evelyne, Phu, Nguyen Hoan, van Doorn, H Rogier, Oanh, Pham Kieu Nguyet, Van Hao, Nguyen, Dung, Nguyen Thi Phuong, Nghia, Ho Dang Trung   +29 more
core   +1 more source

Production, Characterisation and Testing of an Ovine Antitoxin against Ricin; Efficacy, Potency and Mechanisms of Action

Toxins, 2017
Ricin is a type II ribosome-inactivating toxin that catalytically inactivates ribosomes ultimately leading to cell death. The toxicity of ricin along with the prevalence of castor beans (its natural source) has led to its increased notoriety and ...
Sarah J. C. Whitfield, Gareth D. Griffiths, Dominic C. Jenner, Robert J. Gwyther, Fiona M. Stahl, Lucy J. Cork, Jane L. Holley, A. Christopher Green, Graeme C. Clark   +8 more
doaj   +1 more source

A case of asymmetric cranial nerve palsy due to iatrogenic botulism [PDF]

Asia Pacific Journal of Medical Toxicology, 2021
Introduction:Botulism is a rare but lethal disease and atypical clinical presentations of this disease are difficult to diagnose. We report a case of iatrogenic botulism who presented withasymmetric cranial nerve involvement.Case report:An eighteen year ...
Muhammad Akbar Baig, Joshua Nogar
doaj   +1 more source

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology [PDF]

, 2015
Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Gerdes, K., Glatter, Timo, Dehio, Christoph, Alexander Harms, Goepfert, A., Scheu, P., Kenn Gerdes, Glatter, T. ; https://orcid.org/, Schirmer, T., Harms, Alexander, Christoph Dehio, Harms, A., Timo Glatter, Stanger, Frédéric Valentin, Gerdes, Kenn, Dehio, C., Schirmer, Tilman, Harms, Alexander; id_orcid, de Jong, I., de Jong, Imke Greet, Stanger, F., Tilman Schirmer, Patrick Daniel Scheu, Arnaud Goepfert, Scheu, Patrick Daniel, Frédéric Valentin Stanger, Imke Greet de Jong, Goepfert, Arnaud   +27 more
core   +1 more source