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An oxygen-sensitive toxin–antitoxin system
Classical toxin–antitoxin systems in bacteria are based on silencing of a toxin by an antitoxin that, when inactivated, releases the toxin, resulting in a change in metabolism. Here, the authors characterize an oxygen-sensitive toxin–antitoxin system and
Oriol Marimon +13 more
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Postbooster Antibodies from Humans as Source of Diphtheria Antitoxin
Diphtheria antitoxin for therapeutic use is in limited supply. A potential source might be affinity-purified antibodies originally derived from plasma of adults who received a booster dose of a vaccine containing diphtheria toxoid. These antibodies might
Jesús F. Bermejo-Martin +5 more
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Antibodies and Vaccines against Botulinum Toxins: Available Measures and Novel Approaches
Botulinum neurotoxin (BoNT) is produced by the anaerobic, Gram-positive bacterium Clostridium botulinum. As one of the most poisonous toxins known and a potential bioterrosism agent, BoNT is characterized by a complex mode of action comprising ...
Christine Rasetti-Escargueil +1 more
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THE ANTITOXIN OF TETANUS. [PDF]
Among the many principles on which are based our modern theories of the etiology and therapeutics of disease is that of the vaccinating or immunizing power of attenuated cultures of specific microorganisms. Although this principle is forecast by Jenner's discovery of the vaccine against variola, it is to the great Frenchman, Pasteur, that should be ...
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ANTITOXIN AND DIPHTHERIA. [PDF]
At a meeting held here about a year ago I read a paper entitled "Diphtheria," in which the subject was treated in its entirety and some reference was made to the use of antitoxin serum. The paper which I present tonight deals chiefly with antitoxin and some reference is made to diphtheria as seems to be proper or relevant to the subject.
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Ricin, a highly lethal toxin derived from the seeds of Ricinus communis (castor beans) is considered a potential biological threat agent due to its high availability, ease of production, and to the lack of any approved medical countermeasure against ...
Reut Falach +11 more
doaj +1 more source

